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Background: There is little international data on morbidity and mortality of surgery for perforated peptic ulcer (PPU). This study aimed to understand the global 30-day morbidity and mortality of patients undergoing surgery for PPU and to identify variables associated with these. Method: We performed an international study of adults (≥ 18 years) who underwent surgery for PPU from 1st January 2022 to 30th June 2022. Patients who were treated conservatively or had an underlying gastric cancer were excluded. Patients were divided into subgroups according to age (≤ 50 and > 50 years) and time from onset of symptoms to hospital presentation (≤ 24 and > 24 h). Univariate and Multivariate analyses were carried out to identify factors associated with higher 30-day morbidity and mortality. Results: 1874 patients from 159 centres across 52 countries were included. 78.3% (n = 1467) of the patients were males and the median (IQR) age was 49 years (25). Thirty-day morbidity and mortality were 48.5% (n = 910) and 9.3% (n = 174) respectively. Median (IQR) hospital stay was 7 (5) days. Open surgery was performed in 80% (n = 1505) of the cohort. Age > 50 years [(OR = 1.7, 95% CI 1.4–2), (OR = 4.7, 95% CI 3.1–7.6)], female gender [(OR = 1.8, 95% CI 1.4–2.3), (OR = 1.9, 95% CI 1.3–2.9)], shock on admission [(OR = 2.1, 95% CI 1.7–2.7), (OR = 4.8, 95% CI 3.2–7.1)], and acute kidney injury [(OR = 2.5, 95% CI 1.9–3.2), (OR = 3.9), 95% CI 2.7–5.6)] were associated with both 30-day morbidity and mortality. Delayed presentation was associated with 30-day morbidity [OR = 1.3, 95% CI 1.1–1.6], but not mortality. Conclusions: This study showed that surgery for PPU was associated with high 30-day morbidity and mortality rate. Age, female gender, and signs of shock at presentation were associated with both 30-day morbidity and mortality
Global 30-day morbidity and mortality of surgery for perforated peptic ulcer: GRACE study
Abouelazayem, Mohamed;Jain, Rajesh;Wilson, Michael S. J.;Martinino, Alessandro;Balasubaramaniam, Vignesh;Biffl, Walter;Coccolini, Federico;Riera, Manel;Wadhawan, Himanshu;Wazir, Ishaan;Abderaouf, Bettahar;Abramov, Daniil;Abu Jayyab, Mustafa A.;Al-Shami, Khayry;Alfarwan, Ahmad;Alhajami, Faris M.;Alkaseek, Akram;Alozairi, Ous;Ammar, Ahmed Siddique;Atar, Burak;Baatarjav, Gan-Erdene;Bains, Lovenish;Bakri, Ashraf;Bayramov, Nuru;Bhojwani, Rajesh;Brachini, Gioia;Calini, Giacomo;Campanelli, Michela;Cheng, Shi Yu;Choudhary, Charan Singh;Chowdhury, Sharfuddin;Colak, Elif;Das, Jayanta Kumar;Dawani, Surrendar;Dönmez, Turgut;Elzayat, Ibrahim;Erdene, Sarnai;Faizi, Tashaba Qaiser;Frountzas, Maximos;Gafsi, Besma;Gentileschi, Paolo;Guler, Mert;Gupta, Gaurav;Harkati, Nour Elhouda;Harris, Matthew;Hasan, Doaa M.;Irowa, Omorodion Omoruyi;Jafferi, Salman;Jain, Sumita Agarwal;Jun Han, Lai;Kandiboyina, Satyanarayana Murthy;Karabulut, Mehmetu;Khamees, Almu'atasim;Khan, Shahzeb;Khan, Madiha Masood;Khaw, Cheng Jing;Kisielewski, Michal;Klib, Mohamad;Košir, Jurij A.;Krawczyk, Wiktor Jan;Lisi, Giorgio;Makama, Jerry Godfrey;Maqbool, Baila;Marques, Cláudia Neves;Meric, Serhat;Mietła, Mateusz Przemysław;Ads, Alaa Mohamed;Muhumuza, Joshua;Mulita, Francesk;Mustafayeva, Matanat;Omar, Mohammed A.;Omarov, Taryel;Pathak, Akshant Anil;Paul, Ratnadeep;Pavone, Giovanna;Podda, Mauro;Raja Ram, Novinth Kumar;Rauf, Fatima;Rauf, Sidra;Safy, Ahmed Mohamed;Sandag, Erdene;Şanlı, Ahmet Necati;Siddiqui, Adeela Z.;Sotiropoulou, Maria;Talib, Vikash;Tatar, Cihad;Thota, Anuroop;Tokocin, Merve;Tolat, Aditya;Uchikov, Petar Angelov;Valenzuela, José I.;Venkatappa, Sunil Kumar;Verras, Georgios-Ioannis;Vlahović, Ivan;Zreeg, Dafer Abdulhakim S.;Cardoso, Victor Roth;Gkoutos, Georgios V.;Singhal, Rishi;Mahawar, Kamal;null, null;Karim, Mohd Firdaus Bin A.;Raju, Mathiban Raj A/L A Muthu;Aamery, Amaar;Abbass, Ashraf;Abdeewi, Saedah;Abdelaal, Ali Hussien;Abdoun, Meriem;Rahim, Naimat Ullah Abdul;Abdulwahed, Eman Ali;Abizade, Rashad;Abu-Jeyyab, Mohammad;Aceves-Ayala, Jose M.;Acharya, Preeti;Acín-Gándara, Débora;Adeyeye, Ademola A.;Adil, Md Tanveer;Agbonrofo, Peter Ikponmwosa;Ahjaaz, Mabroukah Abraheem;Ahmad, Zarka;Akay, Omer;Al-Robaie, Basim;Al-Shami, Manar;Alabdallah, Nadeem B.;Aldaher, Mohammad;Aldirani, Alaa;Alhaboob, Nassir;Alhadi, Alya;Ali, Qamar Alhaj;Zain, Altayeb Alhaj;Alharthi, Mohammed;Alhashash, Ahmad;Ali Ali, Ahmad;Alkhalaf, Abd Alwahab;Allahverdiyeva, Nigar;Almaqdi, Sarah;Mushaweh, Hala Almohi Alsaid;Aloulou, Mohammad;Alsafi, Sarah;Alshareea, Entisar Ahmed;Alsori, Mohamed;Alwi, Ahmad Fais Mukriz;Aly, Mohamed Mourad;Amaefuna, Kenechukwu David;Amer, Farhah Asilah Binti;Aminu, Bashiru;Anestiadou, Elissavet;Arbutina, Dragana;Ari, Aziz;Arkadopoulos, Nikolaos;Arslan, Kemal;Ascencio-Díaz, Kriscia V.;Ascencio, Evelia Verónica Romo;Askari, Alan;Abdullah, Nora Ra'ed;Attoum, Atiah Rawdah;Atumanyire, Jethro;Avalos-Herrera, Victor J.;Awad, Selmy S.;Azam, Ahmed;Aziz, Sarmad Saeed;Azouz, Jomana Sami;Baccar, Marwen;Badawi, Marwa Mohamed Ali;Bahrudin, Sharhanim Binti;Bakeer, Hibah Bileid;Bakewell, Zoe;Baksi, Aditya;Balbola, Mohammed;Balla, Andrea;Balluerca, Maria;Barbosa, José Adelino Laborinhas;Barbosa, Laura Elisabete Ribeiro;Barbosa-Camacho, Francisco J.;Barreira, Ana Lúcia;Bartosiak, Katarzyna;Basendowah, Mohammed;Basheer, Magdy;Bashiru, Mutiu Adebayo;Basu, Somprakas;Baxter, Zachary;Toro, José Antonio Becerra;Bello, Usman Mohammed;Bellou, Olga;Benavoli, Domenico;Bermingham, Alyson;Bhalla, Bhavneet Singh;Binnawara, Muhannud Hassan;Boddy, Alex;Bolota, Joana S.;Bonatti, Luca;Bonomi, Alessandro Michele;Boras, Zdenko;Bouaoud Bouaoud, Manar M.;Bouaoud, Souad;Bouchenak, Kamel;Bowman, Sarah;Bozkır, Haktan Övül;Brancaccio-Pérez, Irma V.;Breda, Marta;Carganico, Giacomo;Caruana, Clifford;Centonze, Danilo;Cervantes-Guevara, Gabino;Cervantes-Pérez, Enrique;Chandramohan, Jeyadurga C.;Chaouch, Mohamed Ali;Cillara, Nicola;Cismasiu, Brigitta;Cotsoglou, Christian;Creavin, Ben;D'acapito, Fabrizio;Dalloul, Nour A.;Dapri, Giovanni;Dardanov, Dragomir;Das, Bhuban Mohan;De Luca, Maurizio;Degrate, Luca;Demma, Jonathan Abraham;Derwish, Khawla;Distefano, Costanza;Dogjani, Agron;Dong, Zhiyong;Donohoe, Claire;Dorovinis, Panagiotis;Dulac, Anne Sophie;Earley, Helen;Edem, Sanketh;El Boghdady, Michael;Sayed, Mohamed AEl;Shamarka, Ahmed HEl;El-Houssari, Tarek I.;Elemile, Peter Oluwatobi;Elessi, Khamis;Elghadban, Hosam M.;Elgherwi, Laila Kamel;Elghrieb, Ahmed E.;El-Haddad, Mayar;Elhadi, Muhammed;Elshaer, Ahmed Mohammed;Emejulu, Ikenna Cletus;Enani, Ghada;Ercolani, Giorgio;Erginöz, Ergin;Ethiraj, Suraj;Evola, Giuseppe;Faizul, Syaza Najwa Binti;Felsenreich, Daniel Moritz;Zurita, Melissa A. Fernandez;Festa, Federico;Fiore, Alessia;Fishman, Yuri;Fırat, Muratcan;Fouadla, Mimia;Framarini, Massimo;Frattini, Francesco;Fuentes-Orozco, Clotilde;Gahramanova, Farah;Genser, Laurent;Gerges, Farid;Gerogiannis, Ioannis N.;Gerwash, Ahmed Abdualla S.;Ghandour, Munir;Ghazal, Ahmad;Ghazal, Mohamad;Gill, Ali Abdullah;Gineeb, Hana Yousef;Gioco, Rossella;Viswanath, Nakul Gokhare;Gonsaga, Ricardo A. T.;González-Ojeda, Alejandro;Y. González-Ponce, Fanny;Goswami, Aakansha Giri;Graham, Yitka;Granieri, Stefano;Grosek, Jan;Gupta, Rahul;Gupta, Amit;Güzey, Deniz;Guzmán-Ramírez, Bertha G.;Guzmán-Ruvalcaba, Mario J.;Hamayun, Sana;Hamid, Hytham K. S.;Hammadieh, Abdul Rahman;Hasan, Abdallatef;Haseeb, Abdul;Merican, Siti Rahmah Hashim Isa;Hasırcı, İsmail;Hazebroek, Eric J.;Henriques, Susana;Huda, Farhanul;Ibarra-Camargo, Silvia A.;Idiz, Ufuk Oguz;Iles, Kelly;Ioannidis, Orestis;Irmiya, Solomon N.;Jain, Vikas;Jan, Azalea;Jones, Christopher;Juli, Nicholas Jimbun Anak;Justin, Abram Calinton Bin;Kapiris, Stylianos;Kapsampelis, Panagiotis;Kaur, Supreet;Kavalakat, Alfie J.;Kayali, Ahmad Amir H.;Keramida, Myrto D.;Khan, Amir Hamza;Khanduri, Archana;Khatib, Rama;Khattak, Shehrbano;Kim, Choon Keat;Kim, Guowei;Kokoropoulos, Panagiotis;Komorowska, Katarzyna;Košir, Jurij A.;Kosti, Angeliki;Kouicem, Aya Tinhinane;A. Kouicem, Aya Tinhinane;Kovacevic, Bojan;Krishnasamy, Shyam Karuppusamy;Guler, Rabia Kucukarslan;Kumar, Navin;Kurtenkov, Mikhail;Kykalos, Stylianos;Kynjing, Hampher;Lapolla, Pierfrancesco;Larbi, Mohammed Hakim;Lasheen, Omar;Lee, Wan Teng;Lepiane, Pasquale;Licciardello, Alessio;Lima, Rita Rmp;Lodo, Enrico;Lorenc, Zbigniew;Mabood, Waleed;Machairas, Nikolaos;Madhok, Brij;Ali, Mohamed Shafi Mahboob;Mahdi, Ahmed S.;Mahmoud, Hasan;Malibary, Nadim;Mallik, Dhiraj;Mammadova, Shabnam;Mandic, Luka;Mares-País, Roberto;Marom, Gad;Marques, Cláudia Neves;Masri, Ruqaya J.;Masseria, Pietro;Mclean, Annabel M.;Hashim, Mohd Nizam Md;Kamal, Mohd Adlan Bin Md;Medina-García, Manuel;Megaache, Aissam;Mellado-Tellez, Mel P.;Meneghello, Adriel C.;Michalopoulos, Nikolaos V.;Mingoli, Andrea;Mohalal, Mohamed Salah;Mohamad, Ikhwan Sani;Mohamed, Salma Tarek;Fadzil, Maimuna Zahra Binti Mohamed;Mohammad, Almarri;Montuori, Mauro;Mora-Santana, Damián;Moris, Dimitrios;Mosanya, Arinzechukwu O.;Mousafeiris, Vasileios;Mousli, Alaa;Mouzakis, Odysseas;Muftah, Aiman Nuri;Mulita, Francesk;Nabavi, Theodore F.;Nadeesh, Areej Esam Aish;Nájar-Hinojosa, Rodrigo;Najjar, Mahfoud;Nasani, Mohannad;Nastos, Constantinos;Neary, Peter M.;Negm, Ahmed R.;Ochoa-Rodríguez, Itzel;Olmi, Stefano;Oriakhi, Steve-Nation Nehiweze;Orozco-Gallardo, Ana P.;Osarenkhoe, Monday Omoruyi;Ouyahia, Amel A.;Özçelik, Mehmet Faik;Özdemir, Zeynep;Özyalvaç, Ferman Tevfik;Papaconstantinou, Dimitrios;Papadia, Francesco Saverio;Papadoliopoulou, Maria;Papadopoulos, Aristeidis;Papazacharias, Christos;Parmar, Chetan;Paunero, Patricia;Pawan, G.;Quintero, Rocío Pérez;Pinotti, Enrico;Pisanu, Adolfo;Popat, Sunil;Pournaras, Dimitri;Pouwels, Sjaak;Qassab, Omar;Quaglino, Francesco;Anbarasan, Anbarasan Rasadurai R.;Rafique, Mubashir;Rahman, Atiqur;Rais, Mounira M.;Rajayokiam, Malairman R.;Rajput, Deepak;Ramely, Rosnelifaizur;Ramirez-Gónzalez, Luis R.;Ramu, Gopi;Reslan, Nawwar;Riccioli, Giordana;Rohith, Vakulabharanam Naga;Ronoh, Kimutai S.;Roshan, Homayoon;Ruelas-Bravo, Cornelio;Ruiz-Úcar, Elena;Sabir, Alifa;Sabrin, Nait Ali;Sabry, Ahmed Abdelfattah;Şahin, Mehmet Emin;Said, Amira;Sakran, Nasser;Salem, Yara M.;Salleh, Syahrul Anuar;Sangpliang, Virginia;Sapry, Dina Hesham;Savasta, Francesca Maria Chiara;Sawaftah, Khaled Ahmad;Pereira, Juan Pablo Scarano;Schizas, Dimitrios;Sevik, Husnu;Shabbir, Asim;Shahroz, Ahmad;Shames, Haitam;Sharma, Ankur;Shet, Sahil;Shetiwy, Mohamed S.;Shoma, Ashraf;Sial, Fakhar Munir;Sidiropoulos, Theodoros A.;Singh, Sudhir Kumar;So, Jimmy Bok Yan;Soh, Jien Yen;Solaini, Leonardo;Soncini, Stefania;Soula, Enas;Sousa, Fabiana Filipa Silva;Stella, Ludovica;Suárez-Carreón, Luis O.;Sugumar, Dhivakar;Swamad, Mohamed;Syllaios, Athanasios;Symeonidis, Savvas;Tabeti, Benali;Tampaki, Ekaterini Christina;Tartaglia, Nicola;Tay, Yen Zhir;Yusof, Tengku Nazim Bin Tengku;Tewari, Nilanjana;Tidjane, Anisse;Torre, Beatrice;Uccelli, Matteo;Uccelli, Fara M. L.;Uludağ, Server Sezgin;Ulutaş, Mehmet Eşref;Umar, Bashir Musa;Usman, Hyeladi Malgwi;Uwuigbe, Anthony;Vailas, Michail;Vaz, Susan Sofia Gonçalves;Vega-Gastelum, Jesús O.;Veroux, Massimiliano;Viswanath, Yirupaiahgari K. S.;Vlahović, Ivan;Walędziak, Maciej;Mokhter, Wan Mokhzani Wan;Zain, Wan Zainira Wan;Wang, Huaxi;Warda, Hisham H.;Wei, Zhuoqi;Wong, Michael Pak-Kai;Wong, Geoffrey Yuet Mun;Yahya, Maya Mazuwin;Yang, Wah;Yule, Michael S.;Zakaria, Zaidi;Zakaria, Andee Dzukarnaen;Zarate-Casas, Maria F.;Zengin, Kağan;Zhang, Junchang
2024-01-01
Abstract
Background: There is little international data on morbidity and mortality of surgery for perforated peptic ulcer (PPU). This study aimed to understand the global 30-day morbidity and mortality of patients undergoing surgery for PPU and to identify variables associated with these. Method: We performed an international study of adults (≥ 18 years) who underwent surgery for PPU from 1st January 2022 to 30th June 2022. Patients who were treated conservatively or had an underlying gastric cancer were excluded. Patients were divided into subgroups according to age (≤ 50 and > 50 years) and time from onset of symptoms to hospital presentation (≤ 24 and > 24 h). Univariate and Multivariate analyses were carried out to identify factors associated with higher 30-day morbidity and mortality. Results: 1874 patients from 159 centres across 52 countries were included. 78.3% (n = 1467) of the patients were males and the median (IQR) age was 49 years (25). Thirty-day morbidity and mortality were 48.5% (n = 910) and 9.3% (n = 174) respectively. Median (IQR) hospital stay was 7 (5) days. Open surgery was performed in 80% (n = 1505) of the cohort. Age > 50 years [(OR = 1.7, 95% CI 1.4–2), (OR = 4.7, 95% CI 3.1–7.6)], female gender [(OR = 1.8, 95% CI 1.4–2.3), (OR = 1.9, 95% CI 1.3–2.9)], shock on admission [(OR = 2.1, 95% CI 1.7–2.7), (OR = 4.8, 95% CI 3.2–7.1)], and acute kidney injury [(OR = 2.5, 95% CI 1.9–3.2), (OR = 3.9), 95% CI 2.7–5.6)] were associated with both 30-day morbidity and mortality. Delayed presentation was associated with 30-day morbidity [OR = 1.3, 95% CI 1.1–1.6], but not mortality. Conclusions: This study showed that surgery for PPU was associated with high 30-day morbidity and mortality rate. Age, female gender, and signs of shock at presentation were associated with both 30-day morbidity and mortality
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/630450
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.