Objective: Lung cancer is one of the most common and serious typesof cancer. For this reason, novel therapeutic approaches for itstreatment are urgently needed. The aim of this study was toinvestigate the effect of Salvia officinalis essential oil and its threemain components in human lung cancer A549 and NCI-H226 cells.Method: A549 and NCI-H226 cells were treated with variousconcentrations of Salvia officinalis essential oil and with acombination of two and three of its main constituents (1,8-cineole, α-thujone and camphor), at a dose of 100 and 200 g/ml for 48 and 72hours. The anti-proliferative activity was evaluated by the MTTassay.Result: We showed that the treatment with Salvia officinalisessential oil, at a dose of 200 g/ml for 72 hours, caused significantgrowth inhibition on both cell lines, compared with respectivecontrols. The same result was obtained from the treatment with thecombination of α-thujone and 1,8-cineole, α-thujone and camphorand 1,8-cineole and camphor, at a dose of 200 g/ml each for 72hours, and with the association of α-thujone, 1,8-cineole andcamphor at a dose of 100 g/ml each for 48 hours.Conclusion: Based on these preliminary results, Salvia officinaliscould represent an important source of substances with antiproliferativeactivity and could improve the treatment of thisdevastating disease.
In vitro Anti-Proliferative Effect of Salvia officinalis Essential Oil and its Three Main Components on Human Lung Cancer Cells
Luca T;CASTORINA, Sergio
2014-01-01
Abstract
Objective: Lung cancer is one of the most common and serious typesof cancer. For this reason, novel therapeutic approaches for itstreatment are urgently needed. The aim of this study was toinvestigate the effect of Salvia officinalis essential oil and its threemain components in human lung cancer A549 and NCI-H226 cells.Method: A549 and NCI-H226 cells were treated with variousconcentrations of Salvia officinalis essential oil and with acombination of two and three of its main constituents (1,8-cineole, α-thujone and camphor), at a dose of 100 and 200 g/ml for 48 and 72hours. The anti-proliferative activity was evaluated by the MTTassay.Result: We showed that the treatment with Salvia officinalisessential oil, at a dose of 200 g/ml for 72 hours, caused significantgrowth inhibition on both cell lines, compared with respectivecontrols. The same result was obtained from the treatment with thecombination of α-thujone and 1,8-cineole, α-thujone and camphorand 1,8-cineole and camphor, at a dose of 200 g/ml each for 72hours, and with the association of α-thujone, 1,8-cineole andcamphor at a dose of 100 g/ml each for 48 hours.Conclusion: Based on these preliminary results, Salvia officinaliscould represent an important source of substances with antiproliferativeactivity and could improve the treatment of thisdevastating disease.File | Dimensione | Formato | |
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