Focal Nodular Hyperplasia From The Surgery To The Follow-Up. Change Of Therapeutic Approach

Aim: Focal nodular hyperplasia is the second common benign tumor of the liver after hemangioma The aim of the presentreview is to point out the current approach for the differential diagnosis especially with fibrolamellar hepatocellular carcinoma, witha further look to the changes in therapeutic approach, from the surgery to the follow-up.Materials and methods: An electronic search of the literature was made using cancer literature, the PubMed, Scopus and Webof Science database.Results: We included studies published from 1997 to 2014 inclusive, these were excluded case reports, abstracts, non-englishand not relevant studies. Were included fifty-six studies.Conclusion: Although Focal Nodular Hyperplasia is managed conservatively in the majority of cases, it can albeit pose a difficultdiagnostic dilemma. This tumour was once often resected because it was difficult to distinguish from hepatic adenoma, but withmodern multiphase imaging it is now diagnosed strictly by imaging criteria and not resected.