A series of 9-acetamido-1,2,3 4-tetrahydrocarbazoles (2) and 9-(aminoalkyloxyethyl)-1,2,3,4-tetrahydrocarbazoles (4) were prepared and tested for their in vitro antitumor activity. Compounds 4 are highly cytotoxic in almost all subpanel cell lines when tested at 10-4 M, but showed a weak activity at the lowest concentrations employed.
Synthesis and in vitro antitumor activity evaluation of 9-substituted 1,2,3,4-tetrahydrocarbazoles
Monforte P.;Rizzo M.
1996-01-01
Abstract
A series of 9-acetamido-1,2,3 4-tetrahydrocarbazoles (2) and 9-(aminoalkyloxyethyl)-1,2,3,4-tetrahydrocarbazoles (4) were prepared and tested for their in vitro antitumor activity. Compounds 4 are highly cytotoxic in almost all subpanel cell lines when tested at 10-4 M, but showed a weak activity at the lowest concentrations employed.File in questo prodotto:
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