Simple Summary: Polymorphous adenocarcinoma (PAC), the second most prevalent malignant tumour of the minor salivary glands, primarily affects the palate but can also involve the buccal mucosa. This systematic review investigates PAC's clinical characteristics, emphasizing its presence in less-explored anatomical sites. Following PRISMA guidelines, we conducted a thorough search across PubMed, Scopus, andWeb of Science, identifying and analysing 29 relevant studies. Among the 143 PAC patients included in the systematic review (62 males, 75 females, and 6 undefined, with a mean age of 57.4 +/- 14.5 years), the palate was the predominant site affected by PAC (69.2%), followed by the buccal mucosa (8.4%). Additionally, we report two cases of PAC affecting the buccal mucosa, describing the mean features of an uncommon malignant neoplasm of the salivary glands. These findings underscore the significance of recognizing the buccal mucosa as a potential PAC site, urging careful examination during oral assessments due to the polymorphism and lack of pathognomonic signs.Background: Polymorphous adenocarcinoma (PAC) is the second-most common malignant tumour of the minor salivary glands. Although PAC predominantly affects the palate, it can also involve the buccal mucosa. This systematic review aims to investigate the literature data about PAC. Furthermore, we report two cases of patients affected by PAC in an infrequently considered anatomical site. Methods: According to PRISMA guidelines, a systematic review search was conducted on PubMed, Scopus, and Web of Science. Observational studies conducted on patients with a histological diagnosis of PAC were selected and analysed. Furthermore, two cases of patients with PAC affecting the buccal mucosa were reported. Results: Twenty-nine studies were included, and 143 patients affected by PAC were analysed (62 males, 75 females, and 6 undefined, with a mean age of 57.4 +/- 14.5 years). The palate was the most affected site (99/143, 69.2%), followed by the buccal mucosa (12/143, 8.4%). Moreover, we report two cases of patients with PAC affecting the buccal mucosa (one male and one female, with a mean age of 70.5 +/- 2.5 years). Conclusions: The present study underscores the importance of considering the buccal mucosa as a possible location of minor salivary gland tumours; although it is a less-considered affliction, it is not uncommon.

Polymorphous Adenocarcinoma: A Systematic Review of the Literature and Presentation of Two Cases in a Less-Considered Anatomical Site

Alecci, Giuseppe;Magro, Gaetano;Toro, Corrado;Campisi, Giuseppina
2024-01-01

Abstract

Simple Summary: Polymorphous adenocarcinoma (PAC), the second most prevalent malignant tumour of the minor salivary glands, primarily affects the palate but can also involve the buccal mucosa. This systematic review investigates PAC's clinical characteristics, emphasizing its presence in less-explored anatomical sites. Following PRISMA guidelines, we conducted a thorough search across PubMed, Scopus, andWeb of Science, identifying and analysing 29 relevant studies. Among the 143 PAC patients included in the systematic review (62 males, 75 females, and 6 undefined, with a mean age of 57.4 +/- 14.5 years), the palate was the predominant site affected by PAC (69.2%), followed by the buccal mucosa (8.4%). Additionally, we report two cases of PAC affecting the buccal mucosa, describing the mean features of an uncommon malignant neoplasm of the salivary glands. These findings underscore the significance of recognizing the buccal mucosa as a potential PAC site, urging careful examination during oral assessments due to the polymorphism and lack of pathognomonic signs.Background: Polymorphous adenocarcinoma (PAC) is the second-most common malignant tumour of the minor salivary glands. Although PAC predominantly affects the palate, it can also involve the buccal mucosa. This systematic review aims to investigate the literature data about PAC. Furthermore, we report two cases of patients affected by PAC in an infrequently considered anatomical site. Methods: According to PRISMA guidelines, a systematic review search was conducted on PubMed, Scopus, and Web of Science. Observational studies conducted on patients with a histological diagnosis of PAC were selected and analysed. Furthermore, two cases of patients with PAC affecting the buccal mucosa were reported. Results: Twenty-nine studies were included, and 143 patients affected by PAC were analysed (62 males, 75 females, and 6 undefined, with a mean age of 57.4 +/- 14.5 years). The palate was the most affected site (99/143, 69.2%), followed by the buccal mucosa (12/143, 8.4%). Moreover, we report two cases of patients with PAC affecting the buccal mucosa (one male and one female, with a mean age of 70.5 +/- 2.5 years). Conclusions: The present study underscores the importance of considering the buccal mucosa as a possible location of minor salivary gland tumours; although it is a less-considered affliction, it is not uncommon.
2024
PAC
PLGA
buccal mucosa
minor salivary glands
mouth
polymorphous adenocarcinoma
polymorphous low-grade adenocarcinoma
salivary gland neoplasms
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/644834
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