Increased cardiovascular risk has been associated with reduced response to proerectile drugs.The Italian Society of Andrology and SexualMedicine (SIAMS) promoted an independent, multicenter study performed in 604 men (55 ± 12yrs) suffering from erectile dysfunction (ED) to assess multiple health outcomes and response to 6-month vardenafil challenge in a real-life setting. Overall, 30.8% men had metabolic syndrome. Cardiovascular risk stratification revealed a greater number of ED subjects with moderate risk of a major adverse cardiovascular event than the general population ( < 0.01). Age-adjusted pulse pressure was positively correlated with ED severity and negatively with androgens and waist circumference ( < 0.01). A decline in total testosterone was observed with increasing arterial pulse pressure ( < 0.05), which was not accompanied by compensatory LH rise. Follow-up on 185 men treated with vardenafil in an nonrandomized, open, single-arm trial documented a significant rise in IIEF-5 (delta =6.1 ± 4.8) that was maintained in men with high cardiovascular risk. Mild adverse events occurred in <5%, with no differences between cardiovascular risk classes. In summary, ED is a frequent symptom in patients with an elevated, but often unknown, risk of future cardiovascular events. Androgens predict vascular resistance in ED patients. Vardenafil’s response and safety profile were preserved in subjects with higher cardiovascular risk.
|Titolo:||The SIAMS-ED trial: a national, independetn, multicentre study on cardiometabolic and hormonal impairment of men with erectile dysfunction treated with vardenafil|
|Data di pubblicazione:||2014|
|Citazione:||The SIAMS-ED trial: a national, independetn, multicentre study on cardiometabolic and hormonal impairment of men with erectile dysfunction treated with vardenafil / Isidori A.M.; Corona G; Aversa A; Gianfrilli D; Jannini E.A.; Foresta C; Maggi M; Lenzi A; Sebastiano Andò; Gabriella Angelletti; Baldi Matteo; Giancarlo Balercia; Bellastella Giuseppe; CALOGERO A.E.; Domenico Canale; Massimiliano Caprio; Nicola Caretta; Ciotoli Erennio; Giovanni Maria Colpi; Andrea Fabbri; Riccardo Fornengo; Sandro Francavilla; Davide Francomano; Silvia Gavioli; Giagulli Vito Angelo; Elisa Giannetta; Umberto Goglia; Ilacqua Nicola; Sandro La Vignera; Andrea Lemma; MarioMancini; Chiara Manieri; RiccardoMansani; Ministrini Tommaso; Francesco Minuto; Oppo Alessandro; Francesca Paggi; Pivonello Rosario; Pelliccione Fiore; Perri Anna; Sebastio Perrini; Pofi Riccardo; Carlotta Pozza; Emilia Sbardella; Serra Stefano; Antonio Sinisi. - In: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY. - ISSN 1687-8337. - 2014(2014), pp. 858715-858715.|
|Appare nelle tipologie:||1.1 Articolo in rivista|