The effects of chronic administration of epidermal growth factor on diet-induced caries have been studied in rats. Animals fed an Ershoff diet for 90 days showed macroscopical and microscopical evidence of carious lesions in premolars and molars. Treatment with epidermal growth factor (EGF), injected subcultaneously every other day during the 90-day diet period, totally prevented the appearance of carious lesions. An increase in body weight and hypertrophy of parotid and submaxillary glands were also observed in EGF-treated rats. The protective action of EGF on diet-induced caries may depend on a possible increase in saliva production by hypertrophic glands.
Protective action of epidermal growth factor on diet-induced caries in the rat
Drago F.;
1984-01-01
Abstract
The effects of chronic administration of epidermal growth factor on diet-induced caries have been studied in rats. Animals fed an Ershoff diet for 90 days showed macroscopical and microscopical evidence of carious lesions in premolars and molars. Treatment with epidermal growth factor (EGF), injected subcultaneously every other day during the 90-day diet period, totally prevented the appearance of carious lesions. An increase in body weight and hypertrophy of parotid and submaxillary glands were also observed in EGF-treated rats. The protective action of EGF on diet-induced caries may depend on a possible increase in saliva production by hypertrophic glands.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
