The behavioral effects of drugs stimulating PRL secretion have been studied in male rats. Acquisition of active avoidance behavior was facilitated by short- (SHPRL) and long-term hyperprolactinaemia (LHPRL) induced by pituitary homografts under the kidney capsule. Neuroleptics such as haloperidol and bromperidol, caused hyperprolactinaemia and suppressed the acquisition of active avoidance behavior. Sulpiride was not effective in this respect. SHPRL facilitated and LHPRL inhibited sexual behavior of male rats. Haloperidol, but not sulpiride suppressed the sexual capacity of these animals. Sulpiride and domperidone, but not haloperidol, increased the locomotor activity of male rats. These data suggest that differences in the behavioral effects of neuroleptics may depend on their capacity to compete with PRL at the central level.
Side effects of drugs stimulating prolactin secretion on the behavior of male rats
Drago F.;Scapagnini U.
1984-01-01
Abstract
The behavioral effects of drugs stimulating PRL secretion have been studied in male rats. Acquisition of active avoidance behavior was facilitated by short- (SHPRL) and long-term hyperprolactinaemia (LHPRL) induced by pituitary homografts under the kidney capsule. Neuroleptics such as haloperidol and bromperidol, caused hyperprolactinaemia and suppressed the acquisition of active avoidance behavior. Sulpiride was not effective in this respect. SHPRL facilitated and LHPRL inhibited sexual behavior of male rats. Haloperidol, but not sulpiride suppressed the sexual capacity of these animals. Sulpiride and domperidone, but not haloperidol, increased the locomotor activity of male rats. These data suggest that differences in the behavioral effects of neuroleptics may depend on their capacity to compete with PRL at the central level.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
