Idiopathic normal pressure hydrocephalus (iNPH) represents a nosographic entity characterized by phenotypic variability. In this context, the need arises to differentiate iNPH from neurological conditions characterized by impairment in mobility and cognition, including atypical and secondary parkinsonism, with which it shares several common aspects. In this review we will discuss clinical evidence supporting different iNPH clinical phenotypes mimicking Parkinson's disease and secondary/atypical parkinsonism, indicating iNPH as a neurological condition that should be considered by movement disorders specialists. We will also propose a preliminary diagnostic algorithm combining clinical, imaging and biological markers leading to a multidimensional diagnosis of iNPH associated with parkinsonism.

Is normal pressure hydrocephalus a movement disorder?

MOSTILE, Giovanni;DONZUSO, Giulia;ZAPPIA, Mario
2025-01-01

Abstract

Idiopathic normal pressure hydrocephalus (iNPH) represents a nosographic entity characterized by phenotypic variability. In this context, the need arises to differentiate iNPH from neurological conditions characterized by impairment in mobility and cognition, including atypical and secondary parkinsonism, with which it shares several common aspects. In this review we will discuss clinical evidence supporting different iNPH clinical phenotypes mimicking Parkinson's disease and secondary/atypical parkinsonism, indicating iNPH as a neurological condition that should be considered by movement disorders specialists. We will also propose a preliminary diagnostic algorithm combining clinical, imaging and biological markers leading to a multidimensional diagnosis of iNPH associated with parkinsonism.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/664729
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