Sickle cell disease (SCD) is an increasingly relevant condition in Italy due to rising immigration from high-prevalence regions. Early diagnosis through newborn screening and comprehensive management - including hydroxyurea, antibiotic prophylaxis, transfusions and bone marrow transplantation - are essential to improve outcomes. The article covers key clinical issues, from early detection and vaccination to innovative treatments like gene therapy. Its goal is to provide paediatricians with practical guidance for recognizing and treating SCD in children effectively.

SHEDDING LIGHT ON SICKLE CELL DISEASE

Cuzzubbo D.;Russo G.
Ultimo
2025-01-01

Abstract

Sickle cell disease (SCD) is an increasingly relevant condition in Italy due to rising immigration from high-prevalence regions. Early diagnosis through newborn screening and comprehensive management - including hydroxyurea, antibiotic prophylaxis, transfusions and bone marrow transplantation - are essential to improve outcomes. The article covers key clinical issues, from early detection and vaccination to innovative treatments like gene therapy. Its goal is to provide paediatricians with practical guidance for recognizing and treating SCD in children effectively.
2025
Antibiotic prophylaxis
Bone marrow transplantation
Hydroxyurea
Sickle cell disease (SCD)
Transfusions
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/675529
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