The renal hemodynamic response to a meat meal (2 g/kg BW) was studied in 11 healthy children and in 10 children with a mean plasma creatinine concentration of 2.6 ± 0.1 mg/dl due to chronic renal failure (CRF) of various etiologies. In the healthy status, after a meat meal, the glomerular filtration rate (GFR) increased significantly from a baseline value of 119.0 ± 5.0 to a peak of 159 ± 5.8 ml/min x 1.73 m2; in CRF baseline GFR averaged 49 ± 4.0 and at peak 76.6 ± 7.2 ml/min x 1.73 m2 (p < 0.005). The peak GFR response was reached earlier in healthy subjects than in CRF (p < 0.05) and did not correlate with age or with baseline GFR. Renal plasma flow (RPF) in healthy controls increased from 532 ± 32 at baseline to 646 ± 42.9 ml/min x 1.73 m2 after the meat meal (p < 0.005). Also in CRF after a meat meal there was a significant increase in RPF from 278 ± 51 to 65 ± 66 ml/min x 1.73 m2 (p < 0.005). The filtration fraction was not affected. The percent increase over baseline values of GFR and RPF at the peak was significantly higher in diseased children. Renal reserve averaged 28.1 ± 5.3 ml/min in diseased children and 39.7 ± 5.2 ml/min (p < 0.01). The data indicate that (1) a meat meal is a suitable method to recruit renal reserve in normal children and in children with chronic renal failure, and (2) the renal reserve is normal in chronic renal failure.
|Titolo:||The renal hemodynamic response following a meat meal in children with chronic renal failure and in healthy controls|
|Data di pubblicazione:||1990|
|Appare nelle tipologie:||1.1 Articolo in rivista|