Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients

Context: Levothyroxine monotherapy is the treatment of choice for hypothyroid patients because peripheral T4 to T3 conversion is believed to account for the overall tissue requirement for thyroid hormones. However, there are indirect evidences that this may not be the case in all patients. Objective: To evaluate in a large series of athyreotic patients whether levothyroxine monotherapy can normalize serum thyroid hormones and thyroid-pituitary feedback. Design: Retrospective study. Setting: Academic hospital. Patients: 1,811 athyreotic patients with normal TSH levels under levothyroxine monotherapy and 3,875 euthyroid controls. Measurements: TSH, FT4 and FT3 concentrations by immunoassays. Results: FT4 levels were significantly higher and FT3 levels were significantly lower (p[removed]