The aim of our study is to evaluate the genotoxic damage of cells treated with different concentrations of potassium dichromate. For this reason we have utilised U937 cells, a cellular line derived from acute promielocitic leukaemia. Our results show that the minimum concentration of potassium dichromate induces apoptosis in the U937 cells and is of 600 μM, already after 12 hours, the cells treated with potassium dichromate with a concentration of 500 μM presented an apoptosis of 27% while the respective control showed a base apoptosis of 9.5%. Our sperimental data indicate that the model adopted by us, may be a valid instrument to study the citotoxic effects of compounds containing Chromium. In particular we have evidenced a clear genotoxic effect of these compounds demonstrated by a significant increase of the apoptosis percentage which is time and dose dependent. © PI-ME, Pavia 2005.
|Titolo:||In vitro exposure of U937 cells to potassium dichromate: study of apoptosis|
|Autori interni:||TRAVALI, Salvatore|
|Data di pubblicazione:||2005|
|Rivista:||GIORNALE ITALIANO DI MEDICINA DEL LAVORO ED ERGONOMIA|
|Appare nelle tipologie:||1.1 Articolo in rivista|