The presence of copper(II) in the micromolar range modulates the photodegradation rate ofthe fluoroquinolone Rufloxacin (RFX), both under air and in nitrogen saturated aqueous solution. Thephotodegradation rate of RFX under aerobic conditions decreases in the presence of metal ions, and nochange in the nature of the photoproducts is observed. In anaerobic media, RFX photodegradation rateincreases with increasing copper(II) concentration and the photoproducts distribution changes.Copper(II) inhibits formation of type II products of 2'-deoxyguanosine diagnostic of photosensitizationmediated by singlet oxygen. The overall results provide a clear example demonstrating how a biocompatibletrace element influences efficiently not only the bioavailability of a drug but also itsmolecular mechanism of photodegradation and photosensitization.
|Titolo:||Effects of bio-compatible metal ions on rufloxacin photochemistry, photophysics and photosensitization: Copper(II)|
|Data di pubblicazione:||2010|
|Citazione:||Effects of bio-compatible metal ions on rufloxacin photochemistry, photophysics and photosensitization: Copper(II) / MARIA CONSUELO, Cuquerella; Alessandra, Belvedere; Alfio, Catalfo; MIGUEL ANGEL, Miranda; J. C., Scaiano; DE GUIDI, Guido. - In: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY. - ISSN 1011-1344. - 101(2010), pp. 295-303.|
|Appare nelle tipologie:||1.1 Articolo in rivista|