Aim: To evaluate the long-term efficacy and safety of trabeculectomy with or without low-dosage Mitomycin-C (MMC) in primary open-angle glaucoma (POAG). Methods: 114 patients affected by POAG, participating in a randomised clinical trial from 1995 to 1998, were reexamined and their chart reviewed. Patients had undergone in one eye a trabeculectomy with intraoperative application (2 min) of MMC (0.2 mg/ml) or balanced saline solution (BSS), and, if indicated, postoperative laser suture lysis, bleb needling and/or digital massage. Intraocular pressure (I0P), medical therapy, visual field, further glaucoma surgery, cataract surgery and complication rate (leakage, cataract progression, hypotony, blebitis, endophthalmitis) were evaluated. Results: 67 eyes had received MMC and 47 BSS. MMC-treated eyes had a lower mean I0P (13.33 ± 3.35 vs 14.72± 2.19 mm Hg, p = 0.014); in this group, an higher percentage of eyes had IOP≥18 mm Hg (73.1% vs 51.1%, p = 0.027) and IOP≥ 14 mm Hg (56.7% vs 31.9%, p = 0.015); a lower rate had further glaucoma surgery (9% vs 25.5%, p = 0.040), and visual-field damage progression (21.1% vs 48.6%, p = 0.009). No difference was seen in the complication rate: one MMC-treated eye developed blebitis. Conclusions: In POAG low-dose MMC with intensified postoperative management improved the outcome of the trabeculectomy with a low incidence of complications.
|Titolo:||Nine-year follow-up of trabeculectomy with or without low-dosage mitomycin-c in primary open-angle glaucoma|
|Data di pubblicazione:||2008|
|Citazione:||Nine-year follow-up of trabeculectomy with or without low-dosage mitomycin-c in primary open-angle glaucoma / REIBALDI A; UVA M; LONGO A. - In: BRITISH JOURNAL OF OPHTHALMOLOGY. - ISSN 0007-1161. - 92:12(2008), pp. 1666-1670.|
|Appare nelle tipologie:||1.1 Articolo in rivista|