Introduction. Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen. The objective of this study was to verify the proregenerative effects of VEGF in an experimental model of acute liver failure. Materials and methods. Sixty four rats that underwent intraperitoneal injection of carbon tetrachloride (CCl4) were randomly divided into two groups: group B animals received intravenous injection of VEGF(164) 1 hour following CCl4 poisoning. Group A hosts were untreated. To obtain daily liver function tests (LFTs) and histological samples, on each day up to 8 days we sacrificed four rats in each group. Results. The laboratory examinations showed notable alteration of LFTs in group A, while group B revealed only slight changes. The histological examination showed greater liver damage in group A compared with group B. Conclusion. Our results suggest that administration of exogenous VEGF protects the liver from CCl4-induced acute hepatic failure. Further studies are underway to assess whether exogenous VEGF is effective in other liver injuries.

New model of liver regeneration induced through use of vascular endothelial growth factor

GRUTTADAURIA, Salvatore Giovanni;BARTOLONI, Giovanni;TRAVALI, Salvatore;
2006

Abstract

Introduction. Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen. The objective of this study was to verify the proregenerative effects of VEGF in an experimental model of acute liver failure. Materials and methods. Sixty four rats that underwent intraperitoneal injection of carbon tetrachloride (CCl4) were randomly divided into two groups: group B animals received intravenous injection of VEGF(164) 1 hour following CCl4 poisoning. Group A hosts were untreated. To obtain daily liver function tests (LFTs) and histological samples, on each day up to 8 days we sacrificed four rats in each group. Results. The laboratory examinations showed notable alteration of LFTs in group A, while group B revealed only slight changes. The histological examination showed greater liver damage in group A compared with group B. Conclusion. Our results suggest that administration of exogenous VEGF protects the liver from CCl4-induced acute hepatic failure. Further studies are underway to assess whether exogenous VEGF is effective in other liver injuries.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/8948
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