The enantioselective synthesis of homocarbocyclic-20oxo-30-azanucleosides has been performed by cycloaddition reaction of the N-glycosyl nitrones with allyl nucleobases. The use of nitrones originated from two different carbohydrates, the N-ribosyl nitrone and the Nmannosyl nitrone, proceeded in a stereocontrolled and predictable manner with a good degree of enantioselectivity, so allowing an easy entry to both enantiomers

Enantioselective synthesis of homocarbocyclic-2’-oxo-3’-azanucleosides

CHIACCHIO, Ugo;PISTARA', Venerando;
2006-01-01

Abstract

The enantioselective synthesis of homocarbocyclic-20oxo-30-azanucleosides has been performed by cycloaddition reaction of the N-glycosyl nitrones with allyl nucleobases. The use of nitrones originated from two different carbohydrates, the N-ribosyl nitrone and the Nmannosyl nitrone, proceeded in a stereocontrolled and predictable manner with a good degree of enantioselectivity, so allowing an easy entry to both enantiomers
2006
Nucleosides; 1,3-Dipolar cycloaddition; N-glycosyl nitrones
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/8981
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