Solid lipid nanoparticles (SLN) are regarded as interesting carriers to improve sunscreens’ safety andeffectiveness. In this work, surfactant effects on the physico-chemical properties of SLN loading two ofthe most widely used UV-filters, octylmethoxycinnamate (OMC) and butylmethoxydibenzoylmethane(BMBM), were evaluated and the interactions between SLN components and loaded UV-filters wereinvestigated by differential scanning calorimetry (DSC). All the SLN showed a mean size ranging from30 to 95 nm, and a single peak in size distribution. The use of isoceth-20 or oleth-20 as primary surfactantsdid not provide SLN with suitable physico-chemical properties since: (a) OMC loaded SLN provedunstable; (b) BMBM could not be loaded. OMC or BMBM loaded SLN prepared using ceteth-20 as primarysurfactant were stable but their loading capacity lowered when both sunscreens were loaded simultaneously.DSC analyses showed that OMC distributed inside the SLN and caused a decrease of the lipidmatrix molecules cooperativity while BMBM did not affect SLN calorimetric behaviour. When OMC andBMBM were loaded together into these SLN, an interaction between BMBM and OMC occurred. Theseresults suggest that the interactions between sunscreens and between sunscreens and SLN componentsdeserve further investigation to evaluate their effect on UV-filter-loaded SLN effectiveness.
|Titolo:||Differential scanning calorimetry studies on sunscreen loaded solid lipid nanoparticles prepared by the phase inversion temperature method|
|Autori interni:||SARPIETRO, MARIA GRAZIA|
|Data di pubblicazione:||2011|
|Rivista:||INTERNATIONAL JOURNAL OF PHARMACEUTICS|
|Appare nelle tipologie:||1.1 Articolo in rivista|