Patients undergoing long-term highly active antiretroviral therapy treatment are probably at a higher risk of various HIV-related complications. Hyperactivation of The mammalian target of rapamycin (mTOR) has been found to contribute to dysregulated apoptosis and autophagy which determine CD4(+)-T-cell loss, impaired function of innate immunity and development of neurocognitive disorders. Dysregulated mTOR activation has also been shown to play a key part in the development of nephropathy and in the pathogenesis of HIV-associated malignancies. These studies strongly support a multifunctional key role for mTOR in the pathogenesis of HIV-related disorders and suggest that specific mTOR inhibitors could represent a novel approach for the prevention and treatment of these pathologies.
|Titolo:||mTOR as a multifunctional therapeutic target in HIV infection|
|Autori interni:||NICOLETTI, FERDINANDO|
|Data di pubblicazione:||2011|
|Rivista:||DRUG DISCOVERY TODAY|
|Appare nelle tipologie:||1.1 Articolo in rivista|