Almond and VolSurf + modelling procedures allowed the structural design of new di- and mono-heteroaryl-ethylenes. The structural modifications suggested by the molecular modelling were verified by the synthesis of the designed molecules and by the evaluation of their in vitro activities against two lung tumour cell lines, A549 and H226. 2-{(E)-2-[5'-(Dibutylamino)-2,2'-bithien-5-yl]viny1}-1-methylquinolinium iodide exhibited in vitro antiproliferative activity two orders of magnitude higher than that of the most active compound previously synthesized in our laboratory. 2011 Elsevier Masson SAS. All rights reserved.
Almond and VolSurf+ modelling procedures allowed the structural design of new di- and mono-heteroaryl-ethylenes. The structural modifications suggested by the molecular modelling were verified by the synthesis of the designed molecules and by the evaluation of their in vitro activities against two lung tumor cell lines, A549 and H226. 2-{(E)-2-[5’-(dibutylamino)-2,2’-bithien-5-yl]vinyl}-1-methyl-quinolinium iodide exhibited in vitro antiproliferative activity two orders of magnitude higher than that of the most active compound previously synthesized in our laboratory.
Almond and VolSurf + modelling procedures allowed the structural design of new di- and mono-heteroaryl-ethylenes. The structural modifications suggested by the molecular modelling were verified by the synthesis of the designed molecules and by the evaluation of their in vitro activities against two lung tumour cell lines, A549 and H226. 2-{(E)-2-[5'-(Dibutylamino)-2,2'-bithien-5-yl]viny1}-1-methylquinolinium iodide exhibited in vitro antiproliferative activity two orders of magnitude higher than that of the most active compound previously synthesized in our laboratory. 2011 Elsevier Masson SAS. All rights reserved.
Design, synthesis and in vitro antitumour activity of new heteroaryl ethylenes
FORTUNA, COSIMO GIANLUCA;BARRESI, VINCENZA;BONACCORSO, CARMELA;CONSIGLIO, GIUSEPPE;FAILLA, Salvatore;Trovato Salinaro A;MUSUMARRA, Giuseppe
2012-01-01
Abstract
Almond and VolSurf+ modelling procedures allowed the structural design of new di- and mono-heteroaryl-ethylenes. The structural modifications suggested by the molecular modelling were verified by the synthesis of the designed molecules and by the evaluation of their in vitro activities against two lung tumor cell lines, A549 and H226. 2-{(E)-2-[5’-(dibutylamino)-2,2’-bithien-5-yl]vinyl}-1-methyl-quinolinium iodide exhibited in vitro antiproliferative activity two orders of magnitude higher than that of the most active compound previously synthesized in our laboratory.| File | Dimensione | Formato | |
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