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EnglishIn the present paper, we investigate in deeper detail some features of the bistable behavior observed in micellar aggregates of gangliosides. In these systems, a collective transition takes place connected to different possible conformations of the glycosidic headgroup and resulting in different aggregation numbers for different thermal hystories. Light scattering experiments per-formed on mixed micelles indicate that it is the aggregated structure which dictates the conformation a ganglioside monomer assumes, among the allowed ones. Moreover, density measurements confirm the results previously obtained by DSC and show that the conformation of the hydrophobic tails at a given temperature is coupled to that of the headgroup. NMR measurements are consistent with previous results and, on a more local scale, indicate that the hydration of the ganglioside molecule is affected by the conformational transition. (C) 2002 Elsevier Science B.V. All rights reserved.
| Titolo: | Collective phenomena in confined micellar systems of gangliosides |
| Autori interni: | |
| Data di pubblicazione: | 2002 |
| Rivista: | |
| Abstract: | In the present paper, we investigate in deeper detail some features of the bistable behavior observed in micellar aggregates of gangliosides. In these systems, a collective transition takes place connected to different possible conformations of the glycosidic headgroup and resulting in different aggregation numbers for different thermal hystories. Light scattering experiments per-formed on mixed micelles indicate that it is the aggregated structure which dictates the conformation a ganglioside monomer assumes, among the allowed ones. Moreover, density measurements confirm the results previously obtained by DSC and show that the conformation of the hydrophobic tails at a given temperature is coupled to that of the headgroup. NMR measurements are consistent with previous results and, on a more local scale, indicate that the hydration of the ganglioside molecule is affected by the conformational transition. (C) 2002 Elsevier Science B.V. All rights reserved. |
| Handle: | http://hdl.handle.net/20.500.11769/9999 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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