| Nome |
# |
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Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands, file dfe4d229-8912-bb0a-e053-d805fe0a78d9
|
100
|
|
A structure-and ligand-based virtual screening of a database of “small” marine natural products for the identification of “blue” sigma-2 receptor ligands, file dfe4d22c-f857-bb0a-e053-d805fe0a78d9
|
33
|
|
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain, file 787a4eae-ae28-42e4-9c5b-e6ffe33803c3
|
25
|
|
Sigma-2 receptor ligands QSAR model dataset, file dfe4d227-df3b-bb0a-e053-d805fe0a78d9
|
24
|
|
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors, file dfe4d228-8414-bb0a-e053-d805fe0a78d9
|
22
|
|
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists, file dfe4d228-dc11-bb0a-e053-d805fe0a78d9
|
20
|
|
A pseudouridine isoxazolidinyl nucleoside analogue structural analysis: A morphological approach, file dfe4d229-94e2-bb0a-e053-d805fe0a78d9
|
18
|
|
Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma, file dfe4d228-73f3-bb0a-e053-d805fe0a78d9
|
16
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|
Repurposing of human kinase inhibitors in neglected protozoan diseases, file dfe4d228-8263-bb0a-e053-d805fe0a78d9
|
14
|
|
Rescuing Abandoned Molecules as Nav1.7 and
PCSK9 Inhibitors, file dfe4d227-15a3-bb0a-e053-d805fe0a78d9
|
13
|
|
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma, file dfe4d22e-52b1-bb0a-e053-d805fe0a78d9
|
12
|
|
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats, file dfe4d227-13ce-bb0a-e053-d805fe0a78d9
|
11
|
|
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation, file dfe4d228-fcaa-bb0a-e053-d805fe0a78d9
|
11
|
|
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity, file fe5420ee-d461-4cae-a84e-7bc26d42506f
|
11
|
|
Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia, file 063124c7-5567-4085-b223-1475db6dcb7b
|
10
|
|
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands, file 6db428fa-2b5c-4ccb-a8b9-c2dd16f669ab
|
10
|
|
S2RSLDB: A comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands, file dfe4d228-8411-bb0a-e053-d805fe0a78d9
|
9
|
|
Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation, file dfe4d22b-e2ea-bb0a-e053-d805fe0a78d9
|
9
|
|
Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain, file 19b960fa-bdf0-4a9b-a675-1cd31140f124
|
8
|
|
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling, file dfe4d22e-5536-bb0a-e053-d805fe0a78d9
|
8
|
|
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands, file c2cdfff2-b964-4334-90bc-644a48d95784
|
7
|
|
CNS permeability parameters determination through a statistical analysis driven approach, file dfe4d229-efd7-bb0a-e053-d805fe0a78d9
|
7
|
|
Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity, file e24768af-b1a1-41fd-8f0a-3fa79561f01f
|
7
|
|
Nanostructured lipid carrier for the ophthalmic delivery of haloperidol metabolite II valproate ester (±)-MRJF22: A potential strategy in the treatment of uveal melanoma, file 7b4005c3-ad5c-4ee1-a5aa-ea24ec979e9c
|
6
|
|
Nonpeptide Analogues of Dynorphin A(1-8): Design, Synthesis, and Pharmacological Evaluation of k-Selective Agonists, file dfe4d227-48b7-bb0a-e053-d805fe0a78d9
|
6
|
|
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti, file dfe4d229-8dd4-bb0a-e053-d805fe0a78d9
|
6
|
|
Fourfold filtered statistical/computational approach for the identification of imidazole compounds as HO-1 inhibitors from natural products, file dfe4d229-932b-bb0a-e053-d805fe0a78d9
|
6
|
|
New arylethanolimidazole derivatives as HO-1 inhibitors with cytotoxicity against MCF-7 breast cancer cells, file dfe4d22b-f8b7-bb0a-e053-d805fe0a78d9
|
6
|
|
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain, file 27e3a036-d724-4d51-9242-ad75ac53e98b
|
5
|
|
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells, file c4467edb-68a4-4e61-8ef1-53c053dbaea0
|
5
|
|
W/O/W nanoemulsions as a potential platform for nasal delivery of hydrophilic compounds: a preliminary study, file da6869ea-98c9-4be4-853f-68706eded6d8
|
5
|
|
CCB, a novel specific kappa opioid agonist, which discriminates between opioid
and sigma 1 recognition sites, file dfe4d227-0b3c-bb0a-e053-d805fe0a78d9
|
5
|
|
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands, file dfe4d229-a928-bb0a-e053-d805fe0a78d9
|
5
|
|
Chemistry and Biology of Salinomycin and Its Analogues, file dfe4d22a-e97d-bb0a-e053-d805fe0a78d9
|
5
|
|
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist, file dfe4d22a-eed3-bb0a-e053-d805fe0a78d9
|
5
|
|
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells, file dfe4d227-1ce5-bb0a-e053-d805fe0a78d9
|
4
|
|
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats, file dfe4d227-9a5a-bb0a-e053-d805fe0a78d9
|
4
|
|
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures, file dfe4d227-b385-bb0a-e053-d805fe0a78d9
|
4
|
|
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures, file dfe4d227-b386-bb0a-e053-d805fe0a78d9
|
4
|
|
Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity, file dfe4d228-8444-bb0a-e053-d805fe0a78d9
|
4
|
|
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors, file dfe4d228-8ada-bb0a-e053-d805fe0a78d9
|
4
|
|
Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands, file dfe4d22b-a0bb-bb0a-e053-d805fe0a78d9
|
4
|
|
Interaction of new sigma ligands with biomembrane models evaluated by differential scanning calorimetry and Langmuir-Blodgett studies, file dfe4d22e-a07e-bb0a-e053-d805fe0a78d9
|
4
|
|
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity, file f9f8dca3-6ec7-4221-9c41-4760b5c358e4
|
4
|
|
Preliminary in vitro and in vivo studies of (S)-(–)-MRJF22 loaded-NLC for potential treatment of uveal melanoma, file 6b2006fc-bf58-4b5e-9092-a182b3f0a424
|
3
|
|
Solid lipid nanoparticles for sorafenib ophthalmic delivery, file c82e940a-09aa-4f26-915e-9c19590cea41
|
3
|
|
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells, file dfe4d226-f429-bb0a-e053-d805fe0a78d9
|
3
|
|
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect, file dfe4d226-f8f4-bb0a-e053-d805fe0a78d9
|
3
|
|
In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia, file dfe4d227-13a0-bb0a-e053-d805fe0a78d9
|
3
|
|
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation., file dfe4d227-2540-bb0a-e053-d805fe0a78d9
|
3
|
|
Specific kappa opioid receptor agonists, file dfe4d227-ada5-bb0a-e053-d805fe0a78d9
|
3
|
|
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation., file dfe4d227-b6ec-bb0a-e053-d805fe0a78d9
|
3
|
|
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes, file dfe4d228-75b5-bb0a-e053-d805fe0a78d9
|
3
|
|
Haloperidol Metabolite II Valproate Ester: Antiangiogenic Activity in Human Microvascular Retinal Endothelial Cells, file dfe4d228-83c2-bb0a-e053-d805fe0a78d9
|
3
|
|
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer, file dfe4d229-0a61-bb0a-e053-d805fe0a78d9
|
3
|
|
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines, file dfe4d229-5b0e-bb0a-e053-d805fe0a78d9
|
3
|
|
Synthesis of “no-light activated” Ciprofloxacin and Norfloxacin derivatives as potential biofilm dispersant agents, file dfe4d229-8dce-bb0a-e053-d805fe0a78d9
|
3
|
|
Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions, file dfe4d229-9975-bb0a-e053-d805fe0a78d9
|
3
|
|
Development of novel H2S-donor sigma receptor hybrids for the management of pain., file dfe4d229-cad6-bb0a-e053-d805fe0a78d9
|
3
|
|
Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents, file dfe4d22b-b25d-bb0a-e053-d805fe0a78d9
|
3
|
|
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties, file dfe4d22e-c01d-bb0a-e053-d805fe0a78d9
|
3
|
|
NLC for the delivery of new prodrugs in the treatment of uveal melanoma, file 69481d49-69f2-4265-92ca-3e179dc4fa6f
|
2
|
|
NLC as promising platform to deliver new prodrugs in the treatment of ophthalmic cancer, file d5a80cb4-95aa-4ac6-8138-18975cc99ccf
|
2
|
|
Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion, file dfe4d226-f39a-bb0a-e053-d805fe0a78d9
|
2
|
|
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures, file dfe4d227-01d3-bb0a-e053-d805fe0a78d9
|
2
|
|
New benzomorphan derivatives of MPCB as MOP and KOP receptor ligands, file dfe4d227-7d8a-bb0a-e053-d805fe0a78d9
|
2
|
|
SIMULTANEOUS DETERMINATION OF AMPHETAMINE AND ONE OF ITS METABOLITES BY HPLC WITH ELECTROCHEMICAL DETECTION, file dfe4d227-9cf6-bb0a-e053-d805fe0a78d9
|
2
|
|
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review, file dfe4d228-68cb-bb0a-e053-d805fe0a78d9
|
2
|
|
Tumor Targeting Sigma Receptor Ligands: Development of New Molecular Hybrids as Anticancer Therapeutics, file dfe4d228-83ce-bb0a-e053-d805fe0a78d9
|
2
|
|
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis, file dfe4d228-8510-bb0a-e053-d805fe0a78d9
|
2
|
|
Synthesis and evaluation of haloperidol metabolite II prodrugs as anticancer agents, file dfe4d228-8512-bb0a-e053-d805fe0a78d9
|
2
|
|
(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following
hypoxia/reoxygenation injury, file dfe4d228-b637-bb0a-e053-d805fe0a78d9
|
2
|
|
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors, file dfe4d229-0a66-bb0a-e053-d805fe0a78d9
|
2
|
|
New selective Sigma-1/HDACi prodrugs for neurodegenerative disorders, file dfe4d229-75b3-bb0a-e053-d805fe0a78d9
|
2
|
|
Development of NO-releasing sigma receptor hybrids as anticancer agents, file dfe4d229-c844-bb0a-e053-d805fe0a78d9
|
2
|
|
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors, file dfe4d22b-0e1f-bb0a-e053-d805fe0a78d9
|
2
|
|
From Haloperidol to new selective sigma receptor ligands, file dfe4d22b-630b-bb0a-e053-d805fe0a78d9
|
2
|
|
Design, Synthesis and biological evaluation of hybrid MOR agonist/ HDACi molecules as potential therapeutic agents for chronic pain treatment, file 131a87c9-ac21-477e-a7cf-a2e8fc0282fa
|
1
|
|
Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation, file 1a7a5ca9-a377-47d5-aba0-901964b5cd87
|
1
|
|
Design, synthesis and biological evaluation of MOR agonist/HDACi hybrid compounds: a new potential therapeutic strategy for persistent pain management, file 1bcecb82-bba6-40db-82aa-2e0a29029734
|
1
|
|
Hybrid MOR agonist/HDACi molecules as potential new drugs for persistant pain management: design, synthesis and biological evaluation, file 278ca3de-af66-4370-9bff-d32e4e4963fb
|
1
|
|
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands, file 55ff06b0-72d2-41f1-85f5-27687e92977c
|
1
|
|
Tuning Properties for Blood-Brain Barrier Permeation: A Statistics-Based Analysis, file 5995567f-4989-4211-b546-df06e203f39f
|
1
|
|
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands, file 61713f9d-aa40-4ca6-9f1a-63a80ea247ea
|
1
|
|
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists, file af56fd43-07a1-4236-ad34-51fe9af5fc09
|
1
|
|
Synthesis and pharmacological evaluation of potent and enantioselective sigma-1 and sigma-2 ligands, file dfe4d226-f633-bb0a-e053-d805fe0a78d9
|
1
|
|
Novel Sigma Receptor Ligands: Synthesis and Biological Profile, file dfe4d226-f873-bb0a-e053-d805fe0a78d9
|
1
|
|
Evaluation of N-substitution in 6,7-benzomorphan compounds, file dfe4d226-fc05-bb0a-e053-d805fe0a78d9
|
1
|
|
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity, file dfe4d226-fd15-bb0a-e053-d805fe0a78d9
|
1
|
|
Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines, file dfe4d226-fe61-bb0a-e053-d805fe0a78d9
|
1
|
|
Haloperidol metabolite II prodrug: Asymmetric synthesis and biological evaluation on rat C6 glioma cells, file dfe4d226-ff14-bb0a-e053-d805fe0a78d9
|
1
|
|
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma
ligands with antagonist properties, file dfe4d226-ff20-bb0a-e053-d805fe0a78d9
|
1
|
|
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand., file dfe4d227-0617-bb0a-e053-d805fe0a78d9
|
1
|
|
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain
treatment, file dfe4d227-13b8-bb0a-e053-d805fe0a78d9
|
1
|
|
Synthetic Approaches to Bridgehead Nitrogen Methanesulfonamide Derivatives of 3-Amino-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones, Potential COX-2 Selective Inhibitors, file dfe4d227-14b8-bb0a-e053-d805fe0a78d9
|
1
|
|
Synthesis of potential selective COX-2 enzyme inhibitors derived from ethyl ester of 2-isothiocyanato-5-phenyl-3-thiophenecarboxylic acid, file dfe4d227-15d1-bb0a-e053-d805fe0a78d9
|
1
|
|
New bifunctional antioxidant/σ1 agonist ligands: preliminary chemico-physical and biological evaluation, file dfe4d227-1717-bb0a-e053-d805fe0a78d9
|
1
|
|
Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands., file dfe4d227-1cf8-bb0a-e053-d805fe0a78d9
|
1
|
|
Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties, file dfe4d227-2517-bb0a-e053-d805fe0a78d9
|
1
|
|
(+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia, file dfe4d227-28ce-bb0a-e053-d805fe0a78d9
|
1
|
| Totale |
612 |