IRIS
MARRAZZO, Agostino
 Distribuzione geografica
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Continente #
NA - Nord America 11.493
EU - Europa 6.488
AS - Asia 5.603
SA - Sud America 899
AF - Africa 886
OC - Oceania 21
Continente sconosciuto - Info sul continente non disponibili 2
Totale 25.392
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Nazione #
US - Stati Uniti d'America 11.096
SG - Singapore 2.675
IT - Italia 2.015
RU - Federazione Russa 1.981
CN - Cina 1.527
BR - Brasile 741
IE - Irlanda 651
CI - Costa d'Avorio 531
VN - Vietnam 483
UA - Ucraina 398
DE - Germania 310
FR - Francia 308
CA - Canada 289
KR - Corea 273
GB - Regno Unito 179
BD - Bangladesh 125
SN - Senegal 121
NG - Nigeria 112
ES - Italia 101
IN - India 101
FI - Finlandia 99
NL - Olanda 86
JP - Giappone 83
PL - Polonia 80
SE - Svezia 75
HK - Hong Kong 63
AR - Argentina 51
MX - Messico 49
IQ - Iraq 46
ID - Indonesia 42
TR - Turchia 39
ZA - Sudafrica 36
CH - Svizzera 33
UZ - Uzbekistan 29
CZ - Repubblica Ceca 28
AT - Austria 26
EC - Ecuador 26
CL - Cile 22
MA - Marocco 19
VE - Venezuela 19
BE - Belgio 18
GR - Grecia 18
LU - Lussemburgo 18
AU - Australia 17
BJ - Benin 17
KE - Kenya 16
CO - Colombia 15
JM - Giamaica 15
LT - Lituania 15
IR - Iran 14
LB - Libano 13
SA - Arabia Saudita 12
EG - Egitto 10
AE - Emirati Arabi Uniti 9
CR - Costa Rica 9
PK - Pakistan 9
RS - Serbia 9
TN - Tunisia 9
HU - Ungheria 8
AL - Albania 7
HN - Honduras 7
IL - Israele 7
MY - Malesia 7
PY - Paraguay 7
UY - Uruguay 7
BO - Bolivia 6
JO - Giordania 6
NP - Nepal 6
BB - Barbados 5
DO - Repubblica Dominicana 5
OM - Oman 5
DZ - Algeria 4
ET - Etiopia 4
GT - Guatemala 4
KZ - Kazakistan 4
PH - Filippine 4
AO - Angola 3
AZ - Azerbaigian 3
BG - Bulgaria 3
NZ - Nuova Zelanda 3
PA - Panama 3
PE - Perù 3
PS - Palestinian Territory 3
SY - Repubblica araba siriana 3
TT - Trinidad e Tobago 3
BA - Bosnia-Erzegovina 2
BS - Bahamas 2
CG - Congo 2
DK - Danimarca 2
GE - Georgia 2
GY - Guiana 2
HR - Croazia 2
LK - Sri Lanka 2
LV - Lettonia 2
NI - Nicaragua 2
PT - Portogallo 2
RO - Romania 2
SK - Slovacchia (Repubblica Slovacca) 2
TH - Thailandia 2
TW - Taiwan 2
Totale 25.371
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Città #
Dallas 2.143
Singapore 1.626
Santa Clara 1.191
Chandler 916
Moscow 910
San Jose 824
Ashburn 667
Dublin 647
Chicago 563
Abidjan 531
Catania 530
Jacksonville 451
Hefei 346
Boardman 293
Seoul 271
Beijing 254
Los Angeles 216
Civitanova Marche 209
Lauterbourg 193
Nanjing 182
North Charleston 168
Andover 166
Cambridge 166
Lawrence 166
Toronto 147
Ho Chi Minh City 137
Munich 124
Dakar 121
New York 109
Rome 96
Hanoi 93
Houston 91
Council Bluffs 90
Buffalo 86
Des Moines 84
The Dalles 79
Wilmington 77
Tokyo 76
Bremen 70
Naples 69
São Paulo 69
San Mateo 63
Warsaw 63
Helsinki 59
Hong Kong 57
Columbus 56
Dong Ket 55
Lagos 54
Montreal 53
Grafing 52
Amsterdam 51
Saint Petersburg 49
Shenyang 49
Nanchang 48
Orem 44
Atlanta 43
Milan 43
Brooklyn 42
Palermo 41
Abuja 40
Ottawa 40
Denver 36
Hebei 35
Jiaxing 33
Poplar 33
Changsha 32
London 31
Phoenix 30
Tianjin 30
Florence 29
Johannesburg 28
Da Nang 26
Jakarta 25
Rio de Janeiro 24
Stockholm 24
Madrid 23
Messina 23
Belo Horizonte 22
Lappeenranta 21
Leawood 21
Sala Baganza 21
San Francisco 21
Seattle 21
Chennai 20
Haiphong 20
Paris 20
Washington 20
Mexico City 19
Brno 18
Port Harcourt 18
Baghdad 17
Cotonou 17
Misterbianco 17
Brussels 16
Charlotte 16
Marseille 16
Pune 16
Tashkent 16
Boston 15
Falls Church 15
Totale 17.134
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Nome #
How molecular interactions affect crystal morphology: the case of haloperidol 491
Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders 477
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors 299
(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury 209
Antioxidant properties and pharmacokinetic studies of new selective σ1 bifunctional ligands 208
1-Phenyl-3azabicyclo[3.1.0]hexane derivatives as new ligands for sigma receptors 207
(+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia 207
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 205
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells 201
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer 199
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands 196
A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors 192
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review 188
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 187
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells 186
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands 183
HALOPERIDOL METABOLITE II VALPROATE ESTER: ANTIANGIOGENIC ACTIVITY IN HUMAN MICROVASCULAR RETINAL ENDOTHELIAL CELLS 178
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells 177
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 177
Antioxidant activity of (+)-Pentazocine on activated microglia 175
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 174
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 173
A pseudouridine isoxazolidinyl nucleoside analogue structural analysis: A morphological approach 171
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties 167
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties 165
A structure-and ligand-based virtual screening of a database of “small” marine natural products for the identification of “blue” sigma-2 receptor ligands 164
Benzomorphan-based opioid ligands with mixed m agonist/d antagonist activity 162
Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors 160
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review 160
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma 158
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review 157
Crystal morphologies and polymorphs in tolbutamide microcrystalline powder 155
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 154
Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion 154
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 154
Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity 153
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti 153
Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma 151
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors 150
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands 147
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 147
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats 146
Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands. 145
(+)-MR200 derivatives as potential new selective sigma ligands 145
Synthesis of “no-light activated” Ciprofloxacin and Norfloxacin derivatives as potential biofilm dispersant agents 143
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 143
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 142
(+)-MR200 derivatives as potenzial new selective ligands 141
Design of Small Molecules for Oncological and Neurodegenerative Diseases 140
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation 140
Apoptotic effects of (±) MRJF4 in prostate cancer cells 139
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors 139
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands 138
Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 137
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 136
Copper-Catalyzed Coupling Reaction of 2-Thioxo-4-quinazolinone and Thieno[3,2-d]pyrimidin-4-one Methane Sulphonamide with Aryl Iodide : Preparation of Potential COX-2 Selective Inhibitors 135
New arylethanolimidazole derivatives as HO-1 inhibitors with cytotoxicity against MCF-7 breast cancer cells 134
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 133
La modellistica molecolare applicata ai recettori Sigma-1 e Sigma-2: un excursus 133
CNS permeability parameters determination through a statistical analysis driven approach 133
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. 132
Novel sigma 1-antagonists with cis-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect 131
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 131
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management 131
New selective Sigma-1/HDACi prodrugs for neurodegenerative disorders 131
Development of NO-releasing sigma receptor hybrids as anticancer agents 131
In vitro and in vivo studies of ocular topically administered NLC for the treatment of uveal melanoma 130
Correction to Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 130
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity 129
Fourfold filtered statistical/computational approach for the identification of imidazole compounds as HO-1 inhibitors from natural products 128
Development of novel H2S-donor sigma receptor hybrids for the management of pain. 128
Tumor Targeting Sigma Receptor Ligands: Development of New Molecular Hybrids as Anticancer Therapeutics 127
Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase 127
W/O/W Microemulsions for Nasal Delivery of Hydrophilic Compounds: A Preliminary Study 126
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 125
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 125
Sigma-2 receptor ligands QSAR model dataset 125
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation 125
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 125
Analgesici oppioidi 122
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines 122
Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands 120
Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective 120
Preliminary in vitro and in vivo studies of (S)-(–)-MRJF22 loaded-NLC for potential treatment of uveal melanoma 119
Design, Synthesis and biological evaluation of hybrid MOR agonist/ HDACi molecules as potential therapeutic agents for chronic pain treatment 119
Enhancing HDAC Inhibitor Screening: Addressing Zinc Parameterization and Ligand Protonation in Docking Studies 119
Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects 118
Novel Sigma Receptors Ligands-Nitric Oxide Photodonor: Molecular Hybrids for Double-Targeted Antiproliferative Effect 118
Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia 118
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands 117
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity 117
Synthesis of potential selective COX-2 enzyme inhibitors derived from ethyl ester of 2-isothiocyanato-5-phenyl-3-thiophenecarboxylic acid 117
Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents 117
Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches 116
Synthesis of (+)-(1'R,2'S) and (1'S,2'R)-6,11 -dimethyl-1,2,3,4,5,6-hexahydro-3-[[2'-(alkoxycarbonyl)-2'- phenylcycloprophy]methyl]-2,6-methano-3-benzazocin-8-ol. Comparison of the affinities for sigma(1) and opioid receptors with in the diastereoisomeric MPCB and CCB 116
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 116
Design, synthesis and biological evaluation of MOR agonist/HDACi hybrid compounds: a new potential therapeutic strategy for persistent pain management 115
Synthesis and pharmacological evaluation of MRJF4 as new potential anticancer tool 115
Haloperidol Metabolite II Valproate Ester: Antiangiogenic Activity in Human Microvascular Retinal Endothelial Cells 115
Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions 114
Totale 15.420
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Categoria #
all - tutte 79.870
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 79.870
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.302 136 172 28 19 211 20 190 48 103 32 34 309
2022/20232.687 208 157 48 337 219 432 13 469 603 41 116 44
2023/20241.649 80 252 65 97 104 420 84 88 12 40 263 144
2024/20255.330 149 844 242 410 1.006 594 321 229 373 407 343 412
2025/202612.057 721 648 2.396 708 1.621 2.249 1.120 551 668 642 408 325
2026/2027254 254 0 0 0 0 0 0 0 0 0 0 0
Totale 25.948