IRIS
MARRAZZO, Agostino
 Distribuzione geografica
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Continente #
NA - Nord America 9.249
EU - Europa 5.803
AS - Asia 4.591
SA - Sud America 755
AF - Africa 726
OC - Oceania 15
Continente sconosciuto - Info sul continente non disponibili 1
Totale 21.140
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Nazione #
US - Stati Uniti d'America 8.966
SG - Singapore 2.386
RU - Federazione Russa 1.978
IT - Italia 1.814
CN - Cina 1.407
BR - Brasile 662
IE - Irlanda 650
CI - Costa d'Avorio 527
UA - Ucraina 387
DE - Germania 292
CA - Canada 232
VN - Vietnam 216
KR - Corea 187
GB - Regno Unito 121
SN - Senegal 120
FI - Finlandia 84
IN - India 73
FR - Francia 71
JP - Giappone 71
SE - Svezia 71
ES - Italia 70
PL - Polonia 56
NL - Olanda 52
ID - Indonesia 37
HK - Hong Kong 36
AR - Argentina 34
BD - Bangladesh 34
MX - Messico 32
CH - Svizzera 30
TR - Turchia 28
IQ - Iraq 27
CZ - Repubblica Ceca 25
AT - Austria 23
ZA - Sudafrica 22
EC - Ecuador 21
UZ - Uzbekistan 20
LU - Lussemburgo 18
BJ - Benin 17
BE - Belgio 16
GR - Grecia 14
IR - Iran 14
AU - Australia 11
MA - Marocco 11
LT - Lituania 10
AE - Emirati Arabi Uniti 8
CL - Cile 8
CO - Colombia 8
LB - Libano 8
TN - Tunisia 8
VE - Venezuela 8
IL - Israele 7
RS - Serbia 7
KE - Kenya 6
SA - Arabia Saudita 6
HU - Ungheria 5
JM - Giamaica 5
PK - Pakistan 5
UY - Uruguay 5
EG - Egitto 4
HN - Honduras 4
NG - Nigeria 4
PY - Paraguay 4
CR - Costa Rica 3
DO - Repubblica Dominicana 3
KZ - Kazakistan 3
NP - Nepal 3
NZ - Nuova Zelanda 3
OM - Oman 3
PE - Perù 3
AL - Albania 2
AO - Angola 2
AZ - Azerbaigian 2
BB - Barbados 2
BG - Bulgaria 2
DZ - Algeria 2
ET - Etiopia 2
GE - Georgia 2
JO - Giordania 2
PS - Palestinian Territory 2
TT - Trinidad e Tobago 2
BO - Bolivia 1
CG - Congo 1
DK - Danimarca 1
GY - Guiana 1
LK - Sri Lanka 1
ME - Montenegro 1
MY - Malesia 1
NC - Nuova Caledonia 1
NO - Norvegia 1
PH - Filippine 1
RO - Romania 1
SK - Slovacchia (Repubblica Slovacca) 1
TW - Taiwan 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 21.140
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Città #
Dallas 2.127
Singapore 1.410
Santa Clara 1.150
Chandler 916
Moscow 909
Dublin 646
Chicago 559
Abidjan 527
Catania 515
Ashburn 454
Jacksonville 448
Hefei 346
Boardman 293
Beijing 230
Civitanova Marche 209
Seoul 186
Nanjing 182
Los Angeles 172
Andover 166
Cambridge 165
Lawrence 165
Toronto 140
Munich 123
Dakar 120
Des Moines 84
Houston 81
Wilmington 76
Rome 72
New York 71
Bremen 70
Council Bluffs 67
Naples 67
Tokyo 66
Buffalo 64
San Mateo 63
Ho Chi Minh City 60
Dong Ket 55
The Dalles 55
Columbus 54
Grafing 52
São Paulo 50
Helsinki 49
Saint Petersburg 49
Shenyang 49
Nanchang 48
Warsaw 42
Ottawa 38
San Jose 37
Hanoi 36
Milan 36
Hebei 35
Palermo 35
Brooklyn 33
Hong Kong 33
Jiaxing 33
Changsha 32
Denver 29
Tianjin 29
Montreal 27
Florence 26
Poplar 25
Atlanta 24
Jakarta 24
Messina 23
Rio de Janeiro 23
Amsterdam 22
Orem 22
Leawood 21
Sala Baganza 21
Stockholm 21
San Francisco 20
Belo Horizonte 19
Phoenix 19
Brno 18
Washington 18
Cotonou 17
Johannesburg 17
Misterbianco 17
Brussels 16
Lappeenranta 16
London 16
Pune 16
Seattle 16
Chennai 15
Falls Church 15
Boston 14
Redmond 14
San Giovanni la Punta 14
Augusta 13
Curitiba 13
Guangzhou 13
Mascalucia 13
Mexico City 13
Paris 13
Rimini 13
Boydton 12
Centro 12
Luxembourg 12
Madrid 12
Ningbo 12
Totale 14.635
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Nome #
Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders 412
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors 278
Antioxidant properties and pharmacokinetic studies of new selective σ1 bifunctional ligands 188
(+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia 186
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells 184
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 180
(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury 179
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands 177
1-Phenyl-3azabicyclo[3.1.0]hexane derivatives as new ligands for sigma receptors 177
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer 176
A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors 169
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 164
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review 163
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells 159
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 157
HALOPERIDOL METABOLITE II VALPROATE ESTER: ANTIANGIOGENIC ACTIVITY IN HUMAN MICROVASCULAR RETINAL ENDOTHELIAL CELLS 155
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 154
A pseudouridine isoxazolidinyl nucleoside analogue structural analysis: A morphological approach 152
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 150
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells 150
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties 146
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma 141
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review 139
A structure-and ligand-based virtual screening of a database of “small” marine natural products for the identification of “blue” sigma-2 receptor ligands 139
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 139
Antioxidant activity of (+)-Pentazocine on activated microglia 138
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties 137
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti 137
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors 136
Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma 134
Crystal morphologies and polymorphs in tolbutamide microcrystalline powder 133
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review 133
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 133
Benzomorphan-based opioid ligands with mixed m agonist/d antagonist activity 130
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats 130
(+)-MR200 derivatives as potential new selective sigma ligands 129
Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity 129
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 129
Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors 125
Design of Small Molecules for Oncological and Neurodegenerative Diseases 125
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands 125
Synthesis of “no-light activated” Ciprofloxacin and Norfloxacin derivatives as potential biofilm dispersant agents 125
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 125
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands 123
Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion 123
Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands. 121
Copper-Catalyzed Coupling Reaction of 2-Thioxo-4-quinazolinone and Thieno[3,2-d]pyrimidin-4-one Methane Sulphonamide with Aryl Iodide : Preparation of Potential COX-2 Selective Inhibitors 121
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation 120
Apoptotic effects of (±) MRJF4 in prostate cancer cells 119
Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 119
La modellistica molecolare applicata ai recettori Sigma-1 e Sigma-2: un excursus 118
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors 117
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 116
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 115
New selective Sigma-1/HDACi prodrugs for neurodegenerative disorders 115
New arylethanolimidazole derivatives as HO-1 inhibitors with cytotoxicity against MCF-7 breast cancer cells 115
(+)-MR200 derivatives as potenzial new selective ligands 114
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management 113
Sigma-2 receptor ligands QSAR model dataset 113
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 113
Fourfold filtered statistical/computational approach for the identification of imidazole compounds as HO-1 inhibitors from natural products 112
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 111
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. 111
CNS permeability parameters determination through a statistical analysis driven approach 111
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation 110
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 109
Correction to Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 108
Development of novel H2S-donor sigma receptor hybrids for the management of pain. 108
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 108
Synthesis of potential selective COX-2 enzyme inhibitors derived from ethyl ester of 2-isothiocyanato-5-phenyl-3-thiophenecarboxylic acid 107
Tumor Targeting Sigma Receptor Ligands: Development of New Molecular Hybrids as Anticancer Therapeutics 106
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines 106
Development of NO-releasing sigma receptor hybrids as anticancer agents 106
Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective 106
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity 105
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 104
Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase 103
CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites 103
Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia 103
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands 102
How molecular interactions affect crystal morphology: the case of haloperidol 102
Preliminary in vitro and in vivo studies of (S)-(–)-MRJF22 loaded-NLC for potential treatment of uveal melanoma 101
Analgesici oppioidi 101
Novel Sigma Receptors Ligands-Nitric Oxide Photodonor: Molecular Hybrids for Double-Targeted Antiproliferative Effect 101
Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands 101
Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites 101
Design, Synthesis and biological evaluation of hybrid MOR agonist/ HDACi molecules as potential therapeutic agents for chronic pain treatment 100
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 100
Synthesis and pharmacological evaluation of MRJF4 as new potential anticancer tool 100
Haloperidol Metabolite II Valproate Ester: Antiangiogenic Activity in Human Microvascular Retinal Endothelial Cells 100
Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands 100
Tuning Properties for Blood-Brain Barrier Permeation: A Statistics-Based Analysis 100
In vitro and in vivo studies of ocular topically administered NLC for the treatment of uveal melanoma 99
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands 99
Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo 99
Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches 98
S2RSLDB: A comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands 98
W/O/W Microemulsions for Nasal Delivery of Hydrophilic Compounds: A Preliminary Study 97
Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects 97
SYNTHESIS OF (+)-(1'R,2'S) AND (1'S,2'R)-6,11-DIMETHYL-1,2,3,4,5,6-HEXAHYDRO-3-[[2'-(ALKOXYCARBONYL)-2'-PHENYLCYCLOPROPYL]METHYL]-2,6-METHANO-3-BENZAZOCIN-8-OL. COMPARISON OF THE AFFINITIES FOR SIGMA 1 AND OPIOID RECEPTORS WITHIN THE DIASTEREOISOMERIC MPCB AND CCB 97
Totale 12.892
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Categoria #
all - tutte 67.803
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 67.803
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021493 0 0 0 0 0 18 107 7 105 13 155 88
2021/20221.302 136 172 28 19 211 20 190 48 103 32 34 309
2022/20232.687 208 157 48 337 219 432 13 469 603 41 116 44
2023/20241.649 80 252 65 97 104 420 84 88 12 40 263 144
2024/20255.330 149 844 242 410 1.006 594 321 229 373 407 343 412
2025/20268.053 721 648 2.396 708 1.621 1.959 0 0 0 0 0 0
Totale 21.690