IRIS
MARRAZZO, Agostino
 Distribuzione geografica
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Continente #
NA - Nord America 9.151
AS - Asia 4.468
EU - Europa 4.166
SA - Sud America 752
AF - Africa 723
OC - Oceania 15
Continente sconosciuto - Info sul continente non disponibili 1
Totale 19.276
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Nazione #
US - Stati Uniti d'America 8.873
SG - Singapore 2.281
IT - Italia 1.813
CN - Cina 1.398
BR - Brasile 660
IE - Irlanda 649
CI - Costa d'Avorio 527
UA - Ucraina 387
RU - Federazione Russa 359
DE - Germania 291
CA - Canada 229
VN - Vietnam 216
KR - Corea 187
SN - Senegal 120
GB - Regno Unito 114
FI - Finlandia 83
IN - India 72
FR - Francia 71
SE - Svezia 71
JP - Giappone 70
ES - Italia 68
PL - Polonia 54
NL - Olanda 52
ID - Indonesia 36
AR - Argentina 33
BD - Bangladesh 33
HK - Hong Kong 33
CH - Svizzera 30
MX - Messico 30
TR - Turchia 28
IQ - Iraq 27
CZ - Repubblica Ceca 25
AT - Austria 21
EC - Ecuador 21
UZ - Uzbekistan 20
ZA - Sudafrica 19
LU - Lussemburgo 18
BJ - Benin 17
BE - Belgio 16
GR - Grecia 14
IR - Iran 14
AU - Australia 11
MA - Marocco 11
LT - Lituania 9
AE - Emirati Arabi Uniti 8
CL - Cile 8
CO - Colombia 8
LB - Libano 8
TN - Tunisia 8
VE - Venezuela 8
IL - Israele 7
RS - Serbia 7
KE - Kenya 6
SA - Arabia Saudita 6
HU - Ungheria 5
JM - Giamaica 5
PK - Pakistan 5
UY - Uruguay 5
EG - Egitto 4
HN - Honduras 4
NG - Nigeria 4
PY - Paraguay 4
CR - Costa Rica 3
DO - Repubblica Dominicana 3
KZ - Kazakistan 3
NP - Nepal 3
NZ - Nuova Zelanda 3
OM - Oman 3
PE - Perù 3
AL - Albania 2
AO - Angola 2
AZ - Azerbaigian 2
BB - Barbados 2
BG - Bulgaria 2
DZ - Algeria 2
ET - Etiopia 2
GE - Georgia 2
JO - Giordania 2
PS - Palestinian Territory 2
TT - Trinidad e Tobago 2
BO - Bolivia 1
CG - Congo 1
DK - Danimarca 1
GY - Guiana 1
LK - Sri Lanka 1
ME - Montenegro 1
NC - Nuova Caledonia 1
NO - Norvegia 1
RO - Romania 1
SK - Slovacchia (Repubblica Slovacca) 1
TW - Taiwan 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 19.276
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Città #
Dallas 2.125
Singapore 1.307
Santa Clara 1.148
Chandler 916
Dublin 645
Chicago 558
Abidjan 527
Catania 514
Jacksonville 448
Ashburn 434
Hefei 346
Boardman 293
Beijing 230
Civitanova Marche 209
Seoul 186
Nanjing 182
Andover 166
Cambridge 165
Lawrence 165
Los Angeles 165
Toronto 139
Munich 123
Dakar 120
Moscow 117
Des Moines 84
Houston 80
Wilmington 76
Rome 72
Bremen 70
Council Bluffs 67
Naples 67
New York 67
Tokyo 65
Buffalo 64
San Mateo 63
Ho Chi Minh City 60
Dong Ket 55
The Dalles 55
Columbus 54
Grafing 52
São Paulo 50
Helsinki 49
Saint Petersburg 49
Shenyang 49
Nanchang 48
Warsaw 40
Ottawa 38
Hanoi 36
Milan 36
Hebei 35
Palermo 35
Jiaxing 33
Changsha 32
Brooklyn 31
Hong Kong 30
Tianjin 29
Florence 26
Montreal 25
Atlanta 24
Denver 24
Jakarta 23
Messina 23
Rio de Janeiro 23
Amsterdam 22
Leawood 21
Sala Baganza 21
Stockholm 21
Poplar 20
San Francisco 20
Belo Horizonte 19
Phoenix 19
Brno 18
Washington 18
Cotonou 17
Misterbianco 17
Brussels 16
Orem 16
Pune 16
Falls Church 15
Lappeenranta 15
London 15
Seattle 15
Chennai 14
Johannesburg 14
Redmond 14
San Giovanni la Punta 14
Augusta 13
Boston 13
Curitiba 13
Guangzhou 13
Mascalucia 13
Paris 13
Rimini 13
Boydton 12
Centro 12
Luxembourg 12
Madrid 12
Mexico City 12
Ningbo 12
Cagliari 11
Totale 13.638
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Nome #
Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders 403
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors 257
Antioxidant properties and pharmacokinetic studies of new selective σ1 bifunctional ligands 174
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells 167
(+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia 164
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands 160
1-Phenyl-3azabicyclo[3.1.0]hexane derivatives as new ligands for sigma receptors 160
(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury 158
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 158
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer 157
HALOPERIDOL METABOLITE II VALPROATE ESTER: ANTIANGIOGENIC ACTIVITY IN HUMAN MICROVASCULAR RETINAL ENDOTHELIAL CELLS 152
A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors 148
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review 147
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 143
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells 142
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 141
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 135
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti 135
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 132
A pseudouridine isoxazolidinyl nucleoside analogue structural analysis: A morphological approach 132
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells 130
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 129
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties 126
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma 124
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review 122
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 122
Antioxidant activity of (+)-Pentazocine on activated microglia 121
A structure-and ligand-based virtual screening of a database of “small” marine natural products for the identification of “blue” sigma-2 receptor ligands 121
Design of Small Molecules for Oncological and Neurodegenerative Diseases 120
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties 120
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors 119
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 119
Crystal morphologies and polymorphs in tolbutamide microcrystalline powder 117
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review 117
Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma 117
Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity 117
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 116
Benzomorphan-based opioid ligands with mixed m agonist/d antagonist activity 114
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats 114
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 114
Synthesis of “no-light activated” Ciprofloxacin and Norfloxacin derivatives as potential biofilm dispersant agents 112
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands 111
(+)-MR200 derivatives as potential new selective sigma ligands 111
Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors 110
Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands. 110
Copper-Catalyzed Coupling Reaction of 2-Thioxo-4-quinazolinone and Thieno[3,2-d]pyrimidin-4-one Methane Sulphonamide with Aryl Iodide : Preparation of Potential COX-2 Selective Inhibitors 110
Sigma-2 receptor ligands QSAR model dataset 110
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation 110
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands 109
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation 108
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 108
New arylethanolimidazole derivatives as HO-1 inhibitors with cytotoxicity against MCF-7 breast cancer cells 107
La modellistica molecolare applicata ai recettori Sigma-1 e Sigma-2: un excursus 106
Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 104
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines 104
Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion 104
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. 102
Apoptotic effects of (±) MRJF4 in prostate cancer cells 102
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors 102
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 101
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management 101
How molecular interactions affect crystal morphology: the case of haloperidol 101
CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites 101
Fourfold filtered statistical/computational approach for the identification of imidazole compounds as HO-1 inhibitors from natural products 101
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 100
Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase 100
Tumor Targeting Sigma Receptor Ligands: Development of New Molecular Hybrids as Anticancer Therapeutics 99
Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands 99
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 98
(+)-MR200 derivatives as potenzial new selective ligands 98
Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites 98
CNS permeability parameters determination through a statistical analysis driven approach 97
Tuning Properties for Blood-Brain Barrier Permeation: A Statistics-Based Analysis 97
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 96
Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective 96
Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo 95
SYNTHESIS OF (+)-(1'R,2'S) AND (1'S,2'R)-6,11-DIMETHYL-1,2,3,4,5,6-HEXAHYDRO-3-[[2'-(ALKOXYCARBONYL)-2'-PHENYLCYCLOPROPYL]METHYL]-2,6-METHANO-3-BENZAZOCIN-8-OL. COMPARISON OF THE AFFINITIES FOR SIGMA 1 AND OPIOID RECEPTORS WITHIN THE DIASTEREOISOMERIC MPCB AND CCB 95
New selective Sigma-1/HDACi prodrugs for neurodegenerative disorders 95
Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands 95
Synthesis of potential selective COX-2 enzyme inhibitors derived from ethyl ester of 2-isothiocyanato-5-phenyl-3-thiophenecarboxylic acid 94
Development of NO-releasing sigma receptor hybrids as anticancer agents 94
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 94
S2RSLDB: A comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands 93
Development of novel H2S-donor sigma receptor hybrids for the management of pain. 93
Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia 93
Synthesis and pharmacological evaluation of MRJF4 as new potential anticancer tool 92
W/O/W Microemulsions for Nasal Delivery of Hydrophilic Compounds: A Preliminary Study 91
Correction to Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 91
Nonpeptide Analogues of Dynorphin A(1-8): Design, Synthesis, and Pharmacological Evaluation of k-Selective Agonists 91
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity 90
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands 90
Synthesis and antimicrobial evaluation of 4-phenyl-3-isoquinolinoyl-hydrazones 90
Synthesis of Novel Benzylpiperazine Derivatives as Ligands for the σ1 Receptor 90
Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions 90
Chemistry and Biology of Salinomycin and Its Analogues 90
Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches 89
Novel Sigma Receptors Ligands-Nitric Oxide Photodonor: Molecular Hybrids for Double-Targeted Antiproliferative Effect 89
Preliminary in vitro and in vivo studies of (S)-(–)-MRJF22 loaded-NLC for potential treatment of uveal melanoma 88
Synthesis and biological evaluation of new benzo-thieno[3,2-d]pyrimidin-4-one sulphonamide thio-derivatives as potential selective cyclooxygenase-2 inhibitors 88
Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands 87
Totale 11.674
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Categoria #
all - tutte 64.933
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 64.933
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021493 0 0 0 0 0 18 107 7 105 13 155 88
2021/20221.302 136 172 28 19 211 20 190 48 103 32 34 309
2022/20232.687 208 157 48 337 219 432 13 469 603 41 116 44
2023/20241.649 80 252 65 97 104 420 84 88 12 40 263 144
2024/20255.330 149 844 242 410 1.006 594 321 229 373 407 343 412
2025/20266.189 721 648 2.396 708 1.621 95 0 0 0 0 0 0
Totale 19.826