Copper(II)-Catalyzed Alkoxyhalogenation of Alkynyl Ureas and Amides as a Route to Haloalkylidene-Substituted Heterocycles

Gazzola, S; Beccalli, Em; Borelli, T; Castellano, C; Chiacchio, Maria Assunta Rossella; Diamante, D; Broggini, G.

doi:10.1021/acs.joc.5b01227

A highly effective synthesis of haloalkylidene-substituted heterocycles by copper(II)-catalyzed cyclization of alkynyl ureas and secondary amides has been developed. The reaction, which involves a catalytic amount of CuCl2 and a stoichiometric amount of N-halosuccinimide, occurs selectively through an alkoxyhalogenation process. Alternatively, alkoxychlorination and alkoxybromination reactions can be performed working solely with stoichiometric CuCl2 and CuBr2, respectively.

Titolo:	Copper(II)-Catalyzed Alkoxyhalogenation of Alkynyl Ureas and Amides as a Route to Haloalkylidene-Substituted Heterocycles
Autori interni:	Gazzola S Beccalli EM Borelli T Castellano C CHIACCHIO, MARIA ASSUNTA ROSSELLA Diamante D Broggini G. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2015
Rivista:	JOURNAL OF ORGANIC CHEMISTRY
Handle:	http://hdl.handle.net/20.500.11769/18059
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/20.500.11769/18059

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