Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1)

Amata, Emanuele; Nicholas, Bland D.; Robert, Campbell K.; Michael, Pollastri P.

doi:10.1016/j.tetlet.2015.04.061

Human African trypanosomiasis (HAT) is a parasitic disease, caused by the protozoan pathogen Trypanosoma brucei, which affects thousands every year and which is in need of new therapeutics. Herein we report the synthesis and assessment of a series of pyrrolidine and pyrazolone derivatives of human phosphodiesterase 4 (hPDE4) inhibitors for the assessment of their activity against the trypanosomal phosphodiesterase TbrPDEB1. The synthesized compounds showed weak potency against TbrPDEB1

Titolo:	Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1)
Autori interni:	AMATA, EMANUELE Bland D. Nicholas Campbell K. Robert Pollastri P. Michael (Corresponding) mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2015
Rivista:	TETRAHEDRON LETTERS
Handle:	http://hdl.handle.net/20.500.11769/243119
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/20.500.11769/243119

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