Methane sulfonamide derivatives of 3-amino-2-thioxo-2,3-dihydrothieno[2,3-d]pyimidin-4(1H)-one, potential selective COX-2 inhibitors, were synthesized and their structural elucidation is here reported. Some derivatives, at 10 μM concentration, showed a significant percentage of inhibition in some in vitro experiments.
Synthetic Approaches to Bridgehead Nitrogen Methanesulfonamide Derivatives of 3-Amino-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones, Potential COX-2 Selective Inhibitors
MARRAZZO, Agostino;SANTAGATI, Andrea;CARDILE, Venera
2006-01-01
Abstract
Methane sulfonamide derivatives of 3-amino-2-thioxo-2,3-dihydrothieno[2,3-d]pyimidin-4(1H)-one, potential selective COX-2 inhibitors, were synthesized and their structural elucidation is here reported. Some derivatives, at 10 μM concentration, showed a significant percentage of inhibition in some in vitro experiments.File in questo prodotto:
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