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EnglishRBM20 is a nuclear protein which regulates alternative splicing of expressed genes that have a key role in cardiac function. By cloning the human and mouse RBM20 cDNA, producing expressing vectors for truncated proteins, and comparing their sub-cellular distribution in transfected cells, we have identified the sequences necessary for RBM20 full nuclear retention. The region overlaps an RNA binding motif and a serine-arginine domain. The sequence is conserved in many species but belongs only to RBM20 orthologs. The RMB20 tissue specificity, together with the properties of its nuclear localization determinant, demonstrates a specific evolutionary selection of post-transcriptional regulation factors
| Titolo: | Identification of nuclear retention domains in the RBM20 protein |
| Autori interni: | |
| Data di pubblicazione: | 2013 |
| Rivista: | |
| Handle: | http://hdl.handle.net/20.500.11769/320351 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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