A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was obsd. for compds. 17a and 17b: the growth inhibitory effect reaches the 50% in HepG2 and HT-29 cells and increases up to 56% in the SH-SY5Y cell line after 72 h of incubation at a 100 μM concn.
|Titolo:||Synthesis and biological properties of 5-(1H-1,2,3-triazol-4- yl)isoxazolidines: a new class of C-nucleosides|
|Data di pubblicazione:||2015|
|Citazione:||Synthesis and biological properties of 5-(1H-1,2,3-triazol-4- yl)isoxazolidines: a new class of C-nucleosides / Giofre S; Romeo R; Carnovale C; Mancuso R; Cirmi S; Navarra M; Garozzo A; Chiacchio M. - 20:4(2015), pp. 5260-5275.|
|Appare nelle tipologie:||1.1 Articolo in rivista|