A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was obsd. for compds. 17a and 17b: the growth inhibitory effect reaches the 50% in HepG2 and HT-29 cells and increases up to 56% in the SH-SY5Y cell line after 72 h of incubation at a 100 μM concn.

Synthesis and biological properties of 5-​(1H-​1,​2,​3-​triazol-​4- yl)​isoxazolidines: a new class of C-​nucleosides

GAROZZO, Adriana;CHIACCHIO, MARIA ASSUNTA ROSSELLA
2015-01-01

Abstract

A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was obsd. for compds. 17a and 17b: the growth inhibitory effect reaches the 50% in HepG2 and HT-29 cells and increases up to 56% in the SH-SY5Y cell line after 72 h of incubation at a 100 μM concn.
2015
C-nucleosides; Anticancer; triazole
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/33531
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