A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was obsd. for compds. 17a and 17b: the growth inhibitory effect reaches the 50% in HepG2 and HT-29 cells and increases up to 56% in the SH-SY5Y cell line after 72 h of incubation at a 100 μM concn.
Synthesis and biological properties of 5-(1H-1,2,3-triazol-4- yl)isoxazolidines: a new class of C-nucleosides
GAROZZO, Adriana;CHIACCHIO, MARIA ASSUNTA ROSSELLA
2015-01-01
Abstract
A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was obsd. for compds. 17a and 17b: the growth inhibitory effect reaches the 50% in HepG2 and HT-29 cells and increases up to 56% in the SH-SY5Y cell line after 72 h of incubation at a 100 μM concn.File in questo prodotto:
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