2′-Modified inosine analogs have been synthesized from 6-chloropurine riboside via 6-dimethylaminopurine or 6-benzyloxypurine intermediates. The dimethylaminopurine intermediate was obtained via an unusually facile dimethylamine transfer from dimethylformamide.
Synthesis of 2'-Substituted Inosine Analogs via Unusual Masking of the 6-Hydroxyl Group
CHIACCHIO, MARIA ASSUNTA ROSSELLA;
2012-01-01
Abstract
2′-Modified inosine analogs have been synthesized from 6-chloropurine riboside via 6-dimethylaminopurine or 6-benzyloxypurine intermediates. The dimethylaminopurine intermediate was obtained via an unusually facile dimethylamine transfer from dimethylformamide.File in questo prodotto:
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