Hypophosphatemic rickets (HR) is a genetic disorder, which prevents sufficient reabsorption of phosphate in the proximal renal tubule, with increased phosphate excretion, resulting in rickets. The more common form of HR is an X-linked inherited trait, with a prevalence of 1/20,000. The defective gene is located on the X chromosome, but females may present with a wide variety of clinical manifestations. The less common form of HR is caused by autosomal-dominant transmission. Activating mutations of the fibroblast growth factor 23 (FGF-23) gene and inactivating mutations in the phosphate regulating gene (PHEX gene with homologies to endopeptidases on the X chromosome), involved in the regulation of FGF-23, have been identified and have been implicated in the pathogenesis of these disturbances. A review of etiopathogenesis and clinical, differential diagnostic and therapeutic aspects of HR, with a particular emphasis on bone impairment, is reported.
|Titolo:||Hypophosphatemic rickets: etiology, clinical features and treatment|
PAVONE, VITO (Corresponding)
|Data di pubblicazione:||2015|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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|2014 - EJOST - Hypophosphatemic rickets - etiology, clinical features and treatment.pdf||Versione Editoriale (PDF)||Administrator|