A series of N-thienylalkylenediamines was synthesized and tested for their analgesic, anti-inflammatory and anti-pyretic activities, as well as for their acute toxicity and central effects. Acetylsalicylic acid, phenylbutazone and indomethacin were used as reference drugs. Several compounds showed interesting aspirin-like properties associated with good systemic and gastric tolerance.
Synthesis and pharmacological properties of N-thienyl alkylenediamines
RONSISVALLE, Giuseppe;PASQUINUCCI, Lorella Giuseppina;
1988-01-01
Abstract
A series of N-thienylalkylenediamines was synthesized and tested for their analgesic, anti-inflammatory and anti-pyretic activities, as well as for their acute toxicity and central effects. Acetylsalicylic acid, phenylbutazone and indomethacin were used as reference drugs. Several compounds showed interesting aspirin-like properties associated with good systemic and gastric tolerance.File in questo prodotto:
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