Corynebacterium (C.) macginleyi is a gram positive, lipophilic rod, usually considered a colonizer of skin and mucosal surfaces. Several reports haveassociated C. macginleyi with ocular infections, such as conjunctivitis andendophthalmitis. However, even if rare, extraocular infections from C. macginleyimay occur, especially among immunocompromised patients and patients withindwelling medical devices. We report herein the first case of surgical siteinfection by C. macginleyi after orthopaedic surgery for the correction ofkyphoscoliosis in a patient with neurofibromatosis type 1. Our patient developed a nodular granulomatous lesion of about two centimetres along the surgical scar, at the level of C4-C5, with purulent discharge and formation of a fistuloustract. Cervical magnetic resonance imaging showed the presence of atwo-centimetre fluid pocket in the subcutaneous tissue. Several swabs werecollected from the borders of the lesion as well as from the exudate, withisolation of C. macginleyi. The isolate was susceptible to beta-lactams,cotrimoxazole, linezolid, and glycopeptides but resistant to quinolones,third-generation cephalosporins, and erythromycin. Two 30-day courses ofantibiotic therapy with amoxicillin/clavulanate (1 g three times/day) andcotrimoxazole (800/160 mg twice a day) were administered, obtaining a completehealing of the lesion.

Surgical Site Infection by Corynebacterium macginleyi in a Patient with Neurofibromatosis Type 1

Bruno Cacopardo;Stefania Stefani;Francesco Cardi';Carlo Cardi';Giuseppe Nunnari
2013-01-01

Abstract

Corynebacterium (C.) macginleyi is a gram positive, lipophilic rod, usually considered a colonizer of skin and mucosal surfaces. Several reports haveassociated C. macginleyi with ocular infections, such as conjunctivitis andendophthalmitis. However, even if rare, extraocular infections from C. macginleyimay occur, especially among immunocompromised patients and patients withindwelling medical devices. We report herein the first case of surgical siteinfection by C. macginleyi after orthopaedic surgery for the correction ofkyphoscoliosis in a patient with neurofibromatosis type 1. Our patient developed a nodular granulomatous lesion of about two centimetres along the surgical scar, at the level of C4-C5, with purulent discharge and formation of a fistuloustract. Cervical magnetic resonance imaging showed the presence of atwo-centimetre fluid pocket in the subcutaneous tissue. Several swabs werecollected from the borders of the lesion as well as from the exudate, withisolation of C. macginleyi. The isolate was susceptible to beta-lactams,cotrimoxazole, linezolid, and glycopeptides but resistant to quinolones,third-generation cephalosporins, and erythromycin. Two 30-day courses ofantibiotic therapy with amoxicillin/clavulanate (1 g three times/day) andcotrimoxazole (800/160 mg twice a day) were administered, obtaining a completehealing of the lesion.
File in questo prodotto:
File Dimensione Formato  
Surgical site infection....pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Licenza: Non specificato
Dimensione 1.1 MB
Formato Adobe PDF
1.1 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/41615
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact