Arenediyne–isoxazolidine conjugates have been synthesized as a new scaffold for the development ofbioactive mimics. Some of the synthesized compounds are endowed with antiproliferative activityagainst three human cancer cell lines. Their thermal reactivity suggests that the biological activity probablycould not be linked to the Bergman cyclization.
Synthesis and biological activity of new arenediyne-linked isoxazolidines
LANZA, GIUSEPPE;CHIACCHIO, MARIA ASSUNTA ROSSELLA
2014-01-01
Abstract
Arenediyne–isoxazolidine conjugates have been synthesized as a new scaffold for the development ofbioactive mimics. Some of the synthesized compounds are endowed with antiproliferative activityagainst three human cancer cell lines. Their thermal reactivity suggests that the biological activity probablycould not be linked to the Bergman cyclization.File in questo prodotto:
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