Olive Leaf Extract from Sicilian Cultivar Reduced Lipid Accumulation by Inducing Thermogenic Pathway during Adipogenesis

Olive leaves contain a wide variety of phenolic compounds belonging to phenolic acids, phenolicalcohols, flavonoids and secoiridoids, and include also many other pharmacological activecompounds. They could play an important role in human diet and health because of their ability tolower blood pressure, increase coronary arteries blood flow and decrease the risk of cardiovasculardiseases. The aim of this study was to investigate the effect of Olive leaf extract (OLE) fromSicilian cultivar on adipogenic differentiation of human adipose derived mesenchymal stem cellsand its impact on lipid metabolism. We showed that OLE treatment during adipogenicdifferentiation reduces inflammation, lipid accumulation and induces thermogenesis by activationof uncoupling protein UCP1, SIRT-1, PPARα and Pgc-1α. Furthermore, OLE significantlydecreases the expression of molecules involved in adipogenesis and upregulates the expression ofmediators involved in thermogenesis and lipid metabolism. Taken together, our results suggest thatOLE may promote the brown remodeling of white adipose tissue inducing thermogenesis andimproving metabolic homeostasis