IRIS
RONSISVALLE, SIMONE
 Distribuzione geografica
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Continente #
NA - Nord America 4.179
EU - Europa 2.078
AS - Asia 1.397
AF - Africa 296
SA - Sud America 249
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 2
Totale 8.206
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Nazione #
US - Stati Uniti d'America 4.015
IT - Italia 793
SG - Singapore 737
CN - Cina 489
IE - Irlanda 486
UA - Ucraina 357
BR - Brasile 232
CI - Costa d'Avorio 197
CA - Canada 149
RU - Federazione Russa 121
DE - Germania 107
SN - Senegal 73
SE - Svezia 43
VN - Vietnam 39
GB - Regno Unito 32
IN - India 32
JP - Giappone 32
FR - Francia 23
FI - Finlandia 21
NL - Olanda 16
BE - Belgio 15
CH - Svizzera 14
AT - Austria 12
UZ - Uzbekistan 11
MX - Messico 10
GR - Grecia 9
TR - Turchia 9
DZ - Algeria 8
CZ - Repubblica Ceca 7
IR - Iran 7
AR - Argentina 6
IQ - Iraq 6
LB - Libano 6
PL - Polonia 6
AU - Australia 5
CO - Colombia 4
HK - Hong Kong 4
HR - Croazia 4
MA - Marocco 4
NG - Nigeria 4
BG - Bulgaria 3
EG - Egitto 3
PE - Perù 3
ZA - Sudafrica 3
AE - Emirati Arabi Uniti 2
AZ - Azerbaigian 2
CU - Cuba 2
DK - Danimarca 2
EC - Ecuador 2
ES - Italia 2
EU - Europa 2
IL - Israele 2
KZ - Kazakistan 2
MY - Malesia 2
TH - Thailandia 2
TN - Tunisia 2
AL - Albania 1
BA - Bosnia-Erzegovina 1
BD - Bangladesh 1
BH - Bahrain 1
CY - Cipro 1
DO - Repubblica Dominicana 1
GE - Georgia 1
ID - Indonesia 1
JM - Giamaica 1
JO - Giordania 1
KE - Kenya 1
KG - Kirghizistan 1
KW - Kuwait 1
LK - Sri Lanka 1
NO - Norvegia 1
OM - Oman 1
PA - Panama 1
PH - Filippine 1
PK - Pakistan 1
PT - Portogallo 1
PY - Paraguay 1
QA - Qatar 1
RS - Serbia 1
SL - Sierra Leone 1
VE - Venezuela 1
Totale 8.206
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Città #
Santa Clara 704
Chandler 597
Dublin 485
Singapore 441
Jacksonville 385
Chicago 350
Boardman 210
Catania 200
Abidjan 197
Ashburn 170
Houston 145
Nanjing 130
Lawrence 126
Andover 125
Cambridge 125
Toronto 110
Civitanova Marche 92
Dakar 73
San Mateo 67
Wilmington 62
Des Moines 61
Bremen 59
Nanchang 49
Naples 40
Shenyang 40
Council Bluffs 37
Dong Ket 35
Ottawa 33
Saint Petersburg 33
The Dalles 33
Tokyo 32
Tianjin 28
Rome 26
Changsha 24
Hebei 23
Jiaxing 21
Los Angeles 21
Palermo 20
Falls Church 19
Munich 17
Grafing 16
Brussels 15
Mascalucia 15
Milan 15
Pune 14
Shanghai 14
Hefei 13
Seattle 13
Norwalk 12
São Paulo 12
Syracuse 11
Beijing 10
Messina 10
Moscow 10
Dearborn 9
Bari 8
Barlassina 8
Belo Horizonte 8
Helsinki 8
Lappeenranta 8
Viagrande 8
Washington 8
Ardabil 7
East Stroudsburg 7
Jinan 7
Phoenix 7
Ragusa 7
Ann Arbor 6
Augusta 6
Florence 6
Kunming 6
Liberty Lake 6
Padova 6
Rio de Janeiro 6
Acireale 5
Amsterdam 5
Den Haag 5
Guangzhou 5
Hangzhou 5
Modica 5
Monmouth Junction 5
Ningbo 5
San Francisco 5
Tappahannock 5
Abuja 4
Agrigento 4
Albino 4
Brno 4
Bronte 4
Campinas 4
Edinburgh 4
Fairfield 4
Gravina di Catania 4
Hyderabad 4
Livingston 4
Lyon 4
Misterbianco 4
Porto Alegre 4
San Antonio 4
Santa Venerina 4
Totale 5.881
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Nome #
In vitro evaluation of biological activities of Orobanche crenata Forssk. leaves extract 215
Involvement of sigma 2 receptor on motor disorder 165
Biological properties of Cakile maritima Scop. (Brassicaceae) extracts 129
Analysis of common methodological flaws in the highest cited e-cigarette epidemiology research 106
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells 105
(+)Alpha-Lipoic Acid Regulates Lipid Metabolism Gene Expression and Lipidic Profile in a Cellular Model of Fatty Acid Overload 104
Antimicrobial, antioxidant, and cytotoxic activities of Juglans regia L. pellicle extract 102
Antibacterial and anti-biofilm activities of walnut pellicle extract (Juglans regia L.) against coagulase-negative staphylococci 94
Pharmacological properties and biochemical mechanisms of MOR ligands might be due to different binding poses. MD Studies 89
Correction to: Analysis of common methodological flaws in the highest cited e-cigarette epidemiology research (Internal and Emergency Medicine, (2022), 17, 3, (887-909), 10.1007/s11739-022-02967-1) 88
Effects of intraplantar Nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation 88
Competitive Formation of beta-Enaminones and 3-Amino-2(5H)-furanones from the Isoxazolidine System: A Combined Synthetic and Quantum Chemical Study 86
Caspase-3 activation in human melanoma A375 cell line by a novel selective sigma-2 agonist 86
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity 86
Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures 83
A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors 81
The benzomorphan-based compound LP1 is a central acting MOR agonist/DOR antagonist suitable for chronic pain treatment 81
5-Arylidene-4-Thiazolidinone Derivatives Active as Antidegenerative Agents on Human Chondrocyte Cultures 79
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 79
Quantum chemical and molecular dynamics studies of MUC-1 calix[4,8]arene scaffold based anti-cancer vaccine candidates 78
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. 77
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 75
Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma 75
Critical appraisal of the European Union Scientific Committee on Health, Environmental, and Emergency Risks (SCHEER) Preliminary Opinion on electronic cigarettes 74
Benzisothiazolyliminothiazolidin-4-ones with Chondroprotective Properties: Searching for Potent and Selective Inhibitors of MMP-13 74
Heteroarylimino-4-thiazolidinones as inhibitors of cartilage degradation 74
Anti-candidal activity of the parasitic plant orobanche crenata forssk 73
Synthesis and pharmacological evaluation of MRJF4 as new potential anticancer tool 72
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 72
Antioxidant and antimicrobial properties of Casteanea sativa Miller chestnut honey produced on Mount Etna (Sicily) 72
"In vitro" differences among (R) and (S) enantiomers of profens in their activities related to articular pathophysiology. 71
Evaluation of N-substituent structural variations in opioid receptor profile of LP1. 71
Molecular modeling and biological studies show that some μ-opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors 71
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 70
Design and synthesis of trans-decahydroisoquinoline derivatives as new tramadol-like ligands 70
COMPARATIVE STUDY ON CHIRAL SEPARATION OF 3,4-DIHYDROISOQUINOLINE-2(1H)-SULFONAMIDE DERIVATIVES AS POTENT CARBONIC ANYDRASE INHIBITORS 70
From agonist to antagonist profile in LP1 analogues through the introduction of different N-substituents in benzomorphan-based ligands 70
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats 70
Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion 69
Differential scanning calorimetry approach to investigate the transfer of the multitarget opioid analgesic LP1 to biomembrane model 68
Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. 67
Antimicrobial activity of Juglans regia L. pellicle extract 67
EVALUATION OF THE ROLE OF INSTRUMENTAL PARAMETERS DURING THE PREPARATION OF SLN BY ULTRASONIC METHOD 66
Novel Sigma Receptor Ligands: Synthesis and Biological Profile 65
2-Benzisothiazolylimino-5-benzylidene-4-thiazolidinones as protective agents against cartilage destruction 65
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain 65
Synthesis of 5-alkynyl isoxazolidinyl nucleosides 64
Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain 64
Evaluation of (–)-MR22 a novel sigma-1 receptor ligand on lesion-induced memory dysfunctions in the rat 64
(5-Arylidene-2-thioxo-4-oxothiazolidin-3-yl)acetic acids endowed with chondroprotective and matrix metalloproteinase inhibitory activities 64
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 64
Steered molecular dynamics simulations for studying protein-ligand interaction in cyclin-dependent kinase 5 63
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 63
2-Phenylimino-5-arylidene-4-thiazolidinediones. Synthesis and pharmacological evaluation on IL-1-induced alteration in certilage metabolism 63
Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia 63
(+)-MR200 derivatives as potential new selective sigma ligands 62
Synthesis and molecular dynamic studies on 2-(benzisothiazolyl)-N-(4-oxo-2-aryl-thiazolidinyl)-propanamides as potent inhibitors of metalloproteinases 61
Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells 60
Antiallodynic and antihyperalgesic effects of intraplantar nocistatin and (+/-)-J113397 in inflammatory pain 60
An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain 60
In-vitro evaluation of a new benzomorphan-based ligand 60
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 60
Chemical, Antioxidant and Biological Studies of Brassica incana subsp. raimondoi (Brassicaceae) Leaf Extract 59
Modulation of opioid receptor profile of LP1 analogues through the introduction of different N-substituents 59
ANTIALLODYNIC AND ANTIHYPERALGESIC EFFECTS OF INTRAPLANTAR NOCISTATIN AND (±)-J 113397 IN INFLAMMATORY PAIN 59
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures 59
In-silico design and biological investigations of Diabetic Neuropathy modulators: could MOR become a focal mediator for this pathology? 59
Orobanche crenata Forssk. Extract Affects Human Breast Cancer Cell MCF-7 Survival and Viral Replication 58
DISCOVERY OF NEW SIGMA-2 RECEPTOR AGONIST ENDOWED WITH ANTIPROLIFERATIVE ACTIVITY 58
Sigma receptors and tissue transglutaminase in primary rat astroglial cell cultures 57
A New LP1 analogue is used to better understand MOR ligand Binding Domain and its mechanisms of activation 57
In vitro evaluation of new benzomorphan-based ligands 56
Pain management: new long-acting opioid ligands 56
Formulation of germinated brown rice fermented products functionalized by probiotics 55
Glycopeptide- and carbohydrate-based synthetic vaccines for cancer immunotherapy 55
Molecular modeling studies on mu opioid receptor of agonists and antagonists, endogenous and exogenous, ligands 55
Mangifera indica l. Leaf extract induces adiponectin and regulates adipogenesis 55
Benzo [d]isothiazol-3-yl-benzamidines: a Class of Protective Agents on Cultures of Human Cartilage and Chondrocytes Stimulated By IL-1 beta 54
DSC investigation of the effect ofthe new sigma ligand PPCC on DMPC lipid membrane 54
Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity. 53
From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands 53
Effect of a new sigma ligand, (±)PPCC, on KOP receptor mediated analgesia 52
Pain management: new long-acting opioid ligands 52
Synthesis and pharmacological evaluation of novel series of (+)-MR-200 derivatives 51
New " Receptor Ligands with Neuroprotective Effect: Synthesis and Resolution of cis-(±)-Methyl (1R,2S/1S,2R)-2-[(4-Hydroxy-4- phenylpiperidin-1-yl)methyl]-1-(4- methylphenyl)cyclopropanecarboxylate [(±)-PPCC] 51
New benzomorphan derivatives of MPCB as MOP and KOP receptor ligands 51
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1Areceptor agonists 51
Synthesis of MRJF4 enentiomers and evaluation of proapoptotic and cytotoxic effects in cancer cell lines 50
(+)-MR200 derivatives as potenzial new selective ligands 50
Methyl 2-[(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)methyl]-1-phenylcyclopropane-carboxylate enantiomers. Design, synthesis and pharmacological evaluation of opioid receptor affinities 49
Novel sigma receptors ligands as neuroprotective agents 49
The benzomorphan-based LP1 is a central-acting multitarget opioid ligand for chronic pain treatment. 49
In vitro evaluation of new benzomorphan-based ligands 49
Evaluation of N-substitution in 6,7-benzomorphan compounds 49
Effect of hyaluronic acid and polysaccharides from Opuntiaficus indica (L.) cladodes on the metabolism of human chondrocyte cultures 48
In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia 48
Natural flavones and flavonols: relationships among antioxidant activity, glycation and metalloproteinase inhibition 48
LIQUID CHROMATOGRAPHIC DIRECT RESOLUTION OF 1- ARYL-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES ON A CHIRAL STATIONARY PHASE 47
Synthesis and Resolution of cis (±)-Methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl) cyclopropanecarboxylate [(±)-PPCC)]: New Sigma Receptor Ligands with Neuroprotective Effect 47
Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties 47
Totale 6.861
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Categoria #
all - tutte 31.455
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31.455
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020110 0 0 0 0 0 0 0 0 0 0 72 38
2020/2021705 8 63 106 16 201 11 63 3 72 6 99 57
2021/2022933 110 136 3 9 139 17 136 24 93 5 34 227
2022/20231.839 141 96 37 221 155 309 14 302 434 22 78 30
2023/2024981 61 159 41 55 32 195 17 62 16 13 187 143
2024/20252.852 53 561 171 245 639 346 167 139 203 279 49 0
Totale 8.432