IRIS
MODICA, Maria Nunziata
 Distribuzione geografica
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Continente #
NA - Nord America 5.242
EU - Europa 2.425
AS - Asia 1.724
SA - Sud America 394
AF - Africa 264
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 2
Totale 10.053
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Nazione #
US - Stati Uniti d'America 5.062
SG - Singapore 854
CN - Cina 617
IT - Italia 579
IE - Irlanda 501
DE - Germania 404
UA - Ucraina 381
BR - Brasile 359
FI - Finlandia 227
CI - Costa d'Avorio 195
CA - Canada 163
RU - Federazione Russa 125
GB - Regno Unito 51
VN - Vietnam 47
IN - India 44
SN - Senegal 40
FR - Francia 31
SE - Svezia 31
KR - Corea 23
PL - Polonia 22
UZ - Uzbekistan 22
BD - Bangladesh 20
JP - Giappone 17
TR - Turchia 15
ES - Italia 14
IQ - Iraq 14
NL - Olanda 12
ZA - Sudafrica 11
AR - Argentina 10
AT - Austria 10
EC - Ecuador 10
ID - Indonesia 10
MX - Messico 10
CH - Svizzera 8
CZ - Repubblica Ceca 8
IR - Iran 8
VE - Venezuela 7
HK - Hong Kong 6
MA - Marocco 6
PK - Pakistan 6
BG - Bulgaria 5
AE - Emirati Arabi Uniti 4
EG - Egitto 4
PY - Paraguay 4
GR - Grecia 3
JO - Giordania 3
LU - Lussemburgo 3
TN - Tunisia 3
AU - Australia 2
AZ - Azerbaigian 2
EU - Europa 2
HN - Honduras 2
IL - Israele 2
KE - Kenya 2
LB - Libano 2
MD - Moldavia 2
OM - Oman 2
RO - Romania 2
TT - Trinidad e Tobago 2
AO - Angola 1
BE - Belgio 1
BN - Brunei Darussalam 1
CL - Cile 1
CO - Colombia 1
CU - Cuba 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
GY - Guiana 1
HR - Croazia 1
KG - Kirghizistan 1
LT - Lituania 1
LV - Lettonia 1
NG - Nigeria 1
NP - Nepal 1
PH - Filippine 1
PS - Palestinian Territory 1
RS - Serbia 1
SA - Arabia Saudita 1
SV - El Salvador 1
UY - Uruguay 1
Totale 10.053
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Città #
Dallas 1.002
Chandler 665
Singapore 525
Santa Clara 509
Dublin 501
Jacksonville 392
Munich 362
Chicago 283
Ashburn 250
Boardman 219
Abidjan 195
Helsinki 185
Catania 156
Cambridge 141
Nanjing 141
Andover 140
Lawrence 140
Toronto 123
Civitanova Marche 91
San Mateo 77
Beijing 74
Wilmington 65
Houston 56
Des Moines 53
Hefei 52
Nanchang 45
Shenyang 42
Dakar 40
Los Angeles 38
Changsha 37
Hebei 36
São Paulo 36
Council Bluffs 31
Jiaxing 30
Saint Petersburg 29
Rome 28
Columbus 24
Ottawa 24
The Dalles 24
Seoul 23
Tianjin 21
Naples 19
Bremen 18
Redmond 18
Turku 18
Seattle 17
Washington 17
Brooklyn 16
Tokyo 16
Belo Horizonte 15
Pune 15
New York 14
Augusta 13
Dong Ket 13
Jyväskylä 13
Moscow 13
Ho Chi Minh City 12
Norwalk 12
Hanoi 10
Jinan 10
London 10
Mumbai 10
Rio de Janeiro 10
Boston 9
Dhaka 9
Falls Church 9
Jakarta 9
Leawood 9
San Francisco 9
Tashkent 9
Den Haag 8
Johannesburg 8
Palermo 8
Phoenix 8
Warsaw 8
Zhengzhou 8
Ardabil 7
Centro 7
Curitiba 7
Kunming 7
Ningbo 7
Siracusa 7
Atlanta 6
Baghdad 6
Barcelona 6
Florence 6
Goiânia 6
Osio Sotto 6
Fairfield 5
Fortaleza 5
Istanbul 5
Manchester 5
Milan 5
Montreal 5
Redwood City 5
Turin 5
Ankara 4
Boydton 4
Brasília 4
Brno 4
Totale 7.459
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Nome #
(E)-alpha-[[(5-Substituted)1H-indol-3-yl]methylene]benzeneacetic Acid and Amide Derivatives: Synthesis, Characterization, and Evaluation of in vitro Antiproliferative Activity 255
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors 239
3-Arylpiperazynilalkyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives: as novel, potent and selective alpha1-adrenoceptor ligands 231
Application of PARM to constructing and comparing 5-HT1A and alfa1 receptor models 204
[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor 136
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells 132
A focus on Heme Oxygenase-1 (HO-1) inhibitors 118
Attività dei carotenoidi Astaxantina Crocetina e Crocina sulla inibizione dei prodotti della glicazione avanzata. 109
(E)-alfa-[[(5-substituted)1H-indol-3-yl]methylene]benzeneacetic acid and amide derivatives: synthesis, characterization, and evaluation of in vitro antiproliferative activity 108
Solid lipid nanoparticles loading idebenone ester with pyroglutamic acid: In vitro antioxidant activity and in vivo topical efficacy 108
Synthesis and binding properties of novel selective 5-HT3 receptor ligands 107
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 107
Antiproliferative Effect of Plant-Derived Bioactive Compounds Endowed with Antioxidant Activity on Breast Cancer Cells 105
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors 105
Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity 103
Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole, derivatives as potent and selective 5-HT1A serotonin receptor ligands 103
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation 101
(E)-alfa-[[(5-Substituted)1H-indol- 3-yl]methylene]benzeneacetic acid and amide derivatives: synthesis, characterization, and evaluation of in vitro antiproliferative activity 100
Analysis of mechanisms for memory enhancement using novel and potent 5-HT1A receptor ligands 94
New synthetic approaches to bridgehead nitrogen heterocycles derived from 3-amino-2,3-dihydro-5,6-dimethyl-2-thioxo-thieno[2,3-d]pyrimidin-4(1H)-one and its salts 94
Antitumor properties of substituted (alpha E)-alpha-(1H-indol-3-ylmethylene)benzeneacetic acids or amides 94
Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT7 and 5-HT1A receptor ligands 94
Antioxidant Activity and Phenolic Content of Microwave-Assisted Solanum melongena Extracts 94
5-HT7 receptor ligands: recent developments and potential therapeutic applications 93
Caratterizzazione chimico-fisica ed attività antiossidante in vitro del triestere trans-resveratrolotrolox. 92
A New benzoxazolone and benzothiazolone derivatives as potential 5-HT7 receptor ligands 91
5-HT1A receptors mapping by conformational analysis (2D NOESY/MM) and "tree way modelling" (HASL, CoMFA, PARM) 90
High potent and selective arylpiperazine derivatives as ligands for the 5-HT1A receptor 90
A Facile Synthesis of New 2-carboxamido-3-carboxythiophene and 4,5,6,7-tetrahydro-2-carboxyamido-3-carboxythieno[2,3-c]pyridine Derivatives as Potential Endothelin Receptors Ligands 90
S2RSLDB: A comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands 89
3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high affinity and selective alpha1-adrenoceptor ligands 89
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 87
Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands 87
Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective 86
Serotonin 5-HT3 and 5-HT4 Ligands: An Update of Medicinal Chemistry Research in the Last Few Years 85
Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation 85
ATTIVITÀ ANTIOSSIDANTE IN VITRO DI DERIVATI DELL’IDEBENONE 85
Examination of the Novel Sigma‐1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti‐Allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use 85
Development of New Benzylpiperazine Derivatives as σ1Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects 85
In vitro antioxidant activity of idebenone derivative-loaded solid lipid nanoparticles 84
Synthesis of Novel Benzylpiperazine Derivatives as Ligands for the σ1 Receptor 81
SYNTHESIS OF 1,2,4-TRIAZOLE DERIVATIVES: BINDING PROPERTIES ON ENDOTHELIN RECEPTORS 80
Design, sinthesis and binding properties of novel and selective 5-HT3 receptor ligands 80
Synthesis of new thienotriazolopyrimidine and thienopyrimidotetrazine derivatives from bifuctional intermediates 79
Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties 79
New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7 and 5-HT1A receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies 79
Design and synthesis of new homo and hetero bis-piperazinyl-1- propanone derivatives as 5-HT7R selective ligands over 5-HT1AR 79
[[(Arylpiperazinyl)alkylthio]thieno[2,3-d]pyrimidinone derivatives as high-affinity, selective 5-HT1A receptor ligands 78
Application of Parm to constructing and comparing 5-HT1A and alfa1 receptor models 78
Mutual Prodrugs of 5-Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs 77
Synthesis and in vitro antioxidant activity of a novel idebenone ester with pyroglutamic acid. 77
In vitro antioxidant and anti-glycation activity of resveratrol and its novel triester with trolox 77
Heme Oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia 76
Synthesis and experimental validation of new designed heterocyclic compounds with antiproliferative activity versus breast cancer cell lines MCF-7 and MDA-MB-231 76
Synthesis and Endothelin Receptors Binding Affinity of New 1,3,5- Substituted Pyrrole-2-Carboxylic Acid Derivatives 74
Acidi (E)-alfa-[(1H-indol-3-il)metilene]benzeneacetici: una nuova classe di ligandi per i recettori delle endoteline 74
Derivatives of thieno[2,3-d]pyrimidine and evaluation of their biological activity 74
Synthesis and pharmacological screening of 1,3,4-thiadiazino[2,3-b]quinazoline derivatives 74
Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects 73
Synthesis of new 5-phenyl[1,2,4]triazole derivatives as ligands for the 5-HT1A serotonin receptor 73
Synthesis and Binding Properties of New Endothelin Receptor Ligands 73
Building a model of interaction at the NK-2 receptors: polycondensed heterocycles containing the pyrimidoindole skeleton 73
Targeting the hydrophobic heme oxygenase-1 western region for the identification of novel and selective azole-based inhibitors. 73
Conformational analysis and pharmacophore identification of new serotonin 5-HT4 receptor ligands made by DISCO 71
Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-​1 71
Nuovi Arilpiperazinilalchilpirrolopirimidindioni come ligandi potenti e selettivi per i recettori α1-adrenergici 70
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors 70
Design and synthesis of novel potential ligands for endothelin receptors 68
5-HT1A receptors mapping by conformational analysis (2D NOESY/MM) and ”three way modelling” (HASL, CoMFA, PARM) 67
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as novel ligands for the 5-HT7 receptor 66
Synthesis of 2,3-dihydro-3-amino-6-phenyl-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one and of potential antiinflammatory agents 2-aryl-7-phenyl-3H,9H-pyrimido[2,1-b]thieno[2',3':4,5][1,3,4]thiadiazin-9-ones 66
Novel Caffeic Acid Phenethyl Ester (CAPE) Analogues as Inducers of Heme Oxygenase-1 65
Arylpiperazinylalkylthio benzothiazole or benzoxazole derivatives as selective 5-HT1A serotonin receptor ligands 64
A new heterocyclic ring system: synthesis of pyrazolo[3',4':4,5]pyrimido-[2,1-a]phthalazine derivatives 64
Novel arylpiperazine ligands with high affinity for alpha1-adrenergic receptor subtypes 63
5-HT1A receptor binding analysis of thienopyrimidinones partial agonists: a paradigm breaking study regarding the pharmacophoric leadership of the protonated piperazine ring in GPCR ligands 61
Novel (E)-alpha-[(1H-indol-3-yl)methylene]benzeneacetic Acids as Endothelin Receptor Ligands. 60
Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for alpha1-adrenoceptor subtypes. 60
New compounds controlling NO overproduction 59
Design and Synthesis of New 3-Aryl-5-oxoprolines as Potential Ligands for Human Cloned Endothelin Receptors 59
Synthesis and endothelin receptor binding affinity of a novel class of 2-substituted-4-aryl-3-quinolinecarboxylic acid derivatives 58
Design and Synthesis of Novel Potential Ligands for Endothelin Receptors 58
New benzoxazole and benzothiazole derivatives as potential 5-HT7 receptor ligands 58
Receptor modeling using " Multiconformer" alignment: comparison of HASL and CoMFA in the analysis of 5-HT1A thienopyrimidinone ligands 58
Synthesis of piperazinyl-alkylthiothieno[2,3-d]pyrimidine derivatives and serotonergic activity avaluation 58
New Piperidin-2,6-dione Derivatives as Ligands for the alpha1-Adrenoceptor Subtypes 58
Synthesis of 2,3,5,6,7,8-hexahydro-3-amino-thioxo[1]benzothieno[2,3-d]-pyrimidin-4(1H)-one and derivatives of the new heterocyclic system 7,8,9,10-tetrahydro-3H,11H-[1]benzothieno[2',3':4,5]pyrimido[2,1-b][1,3,4]-thiadiazin-11-one 58
Caffeic Acid Phenethyl Ester (CAPE) derivatives as novel heme oxygenase-1 inducers. 57
Synthesis of 1-phenyl-6-arilsubstituted pyrazolopyrimidothiazole as antagonists at the NK-2 receptors 57
Caffeic acid phenetyl ester (CAPE) derivatives as novel heme oxygenase-1 inducers 57
New Pyrimido[5,4-b]indoles and [1]Benzothieno[3,2-d]pyrimidines. High Affinity Ligands for the a 1 - Adrenoceptor Subtypes 57
Potential of indole skeleton containing heterocycles as antagonists at the neurokinin (NK) receptor system 57
Strategies to improve resveratrol systemic and topical bioavailability: An update 56
New Synthetic approaches to fused heterocycloquinazolines 55
Targeting Heme Oxygenase-1 to Overcome Imatinib Resistance in Chronic Myeloid Leukemia 55
Synthesis and endothelin receptor binding affinity of a novel class of (E)-alpha-[[(5-phenylmethoxy)-1H-indol-3-yl]methylene]benzeneacetic acids 54
Evaluation of Imidazole-Based Compounds as Heme Oxygenase-1 Inhibitors 54
Novel inhibitors of nitric oxide synthase with antioxidant properties 54
Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents 53
New thienopyrimidine and quinazoline derivatives as potential 5-HT7 receptor ligands. 53
Totale 8.420
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Categoria #
all - tutte 36.162
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 36.162
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021539 0 0 0 13 218 11 72 4 49 9 132 31
2021/20221.043 130 145 21 10 150 16 149 42 92 7 49 232
2022/20231.801 166 101 39 196 190 314 1 295 392 23 64 20
2023/2024792 39 107 38 33 68 218 5 50 2 20 132 80
2024/20253.187 24 478 165 173 539 345 317 223 323 220 192 188
2025/20261.686 329 184 1.114 59 0 0 0 0 0 0 0 0
Totale 10.351