Le operazioni circolatorie decentralizzate di bitcoin

Delineata la rilevanza giuridica ed economica del bitcoin l’attenzione si sofferma sul relativo regime circolatorio, su gli scambi che avvengono in maniera decentralizzata ovvero attraverso prestatori di servizi decentralizzati. Il Regolamento europeo (c.d. Re golamento MICA) sulle cripto-attività, recepito in Italia con il d.lgs. 5 settembre 2024, n. 129, non si applica alle prestazioni di servizi totalmente decentralizzate e, per gran parte, alle cripto-attività prive di emittente, come...

A Multicenter Real-Life Evaluation of Safety and Effectiveness of the Antibody-Drug Conjugate Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

Objectives: Randomized trials showed that the third-generation antibody-drug conjugate, sacituzumab govitecan (SG), is active against metastatic triple-negative breast cancer (mTNBC). Real-world data are relatively limited. This retrospective study reports the efficacy and safety of SG in a series of women with mTNBC in clinical practice. Methods: Eighty-four patients with widely pretreated, de novo, or metachronous mTNBC were treated with SG at the recommended dose of 10 mg/kg on days 1 and ...

RSC4All as a machine learning nomogram to predict RSClin™ results in HR+/HER2- node-negative early breast cancer

Background: RSClin™ combines clinicopathological (CP) and genomic data to refine predictions of distant recurrence (DR) risk and chemotherapy (CT) benefit in node-negative (N0) hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (eBC). Available in the United States, RSClin™ is inaccessible in Europe due to regulatory constraints. We developed and validated RSC4All, a machine learning (ML) nomogram replicating RSClin™ predictions and eva...

Speckle-tracking echocardiography and arrhythmic risk stratification in or Hypertrophic Cardiomyopathies