IRIS
INTAGLIATA, SEBASTIANO
 Distribuzione geografica
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Continente #
NA - Nord America 3.247
EU - Europa 2.180
AS - Asia 1.604
SA - Sud America 321
AF - Africa 232
Continente sconosciuto - Info sul continente non disponibili 154
OC - Oceania 4
Totale 7.742
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Nazione #
US - Stati Uniti d'America 3.154
IT - Italia 916
SG - Singapore 791
RU - Federazione Russa 641
CN - Cina 419
BR - Brasile 279
IE - Irlanda 196
VN - Vietnam 120
CI - Costa d'Avorio 102
FR - Francia 91
DE - Germania 80
KR - Corea 61
SN - Senegal 48
CA - Canada 46
GB - Regno Unito 43
UA - Ucraina 39
IN - India 35
NG - Nigeria 32
BD - Bangladesh 31
SE - Svezia 31
FI - Finlandia 28
JP - Giappone 24
IQ - Iraq 23
ES - Italia 22
MX - Messico 21
HK - Hong Kong 20
PL - Polonia 20
NL - Olanda 16
TR - Turchia 15
CZ - Repubblica Ceca 14
ZA - Sudafrica 14
AR - Argentina 13
PK - Pakistan 12
KE - Kenya 10
EG - Egitto 8
ID - Indonesia 8
JM - Giamaica 7
LT - Lituania 7
BJ - Benin 6
CH - Svizzera 6
CO - Colombia 6
EC - Ecuador 6
GR - Grecia 6
GT - Guatemala 6
UZ - Uzbekistan 6
AT - Austria 5
CL - Cile 5
VE - Venezuela 5
AU - Australia 4
AZ - Azerbaigian 4
IR - Iran 4
JO - Giordania 4
OM - Oman 4
SA - Arabia Saudita 4
TT - Trinidad e Tobago 4
AE - Emirati Arabi Uniti 3
DO - Repubblica Dominicana 3
MA - Marocco 3
RO - Romania 3
AL - Albania 2
BG - Bulgaria 2
BY - Bielorussia 2
CM - Camerun 2
ET - Etiopia 2
GY - Guiana 2
HU - Ungheria 2
IL - Israele 2
KG - Kirghizistan 2
LB - Libano 2
LU - Lussemburgo 2
MT - Malta 2
NP - Nepal 2
PE - Perù 2
PH - Filippine 2
PY - Paraguay 2
SV - El Salvador 2
TN - Tunisia 2
BE - Belgio 1
BO - Bolivia 1
BZ - Belize 1
CG - Congo 1
DM - Dominica 1
GA - Gabon 1
GE - Georgia 1
GH - Ghana 1
HN - Honduras 1
KZ - Kazakistan 1
LV - Lettonia 1
MY - Malesia 1
PR - Porto Rico 1
PS - Palestinian Territory 1
PT - Portogallo 1
RS - Serbia 1
SY - Repubblica araba siriana 1
TW - Taiwan 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 7.589
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Città #
Dallas 643
Singapore 485
Santa Clara 299
Moscow 296
Chandler 276
San Jose 236
Catania 208
Dublin 192
Chicago 184
Ashburn 183
Beijing 108
Abidjan 102
Boardman 84
Hefei 79
Houston 71
Los Angeles 62
Seoul 60
Lauterbourg 58
Rome 55
Cambridge 51
Lawrence 49
Dakar 48
Andover 46
New York 41
São Paulo 41
Naples 39
Ho Chi Minh City 38
Redmond 38
Palermo 37
Council Bluffs 36
Civitanova Marche 34
Jacksonville 31
Hanoi 27
Munich 26
Tokyo 24
Buffalo 23
Milan 23
Des Moines 22
Nanjing 22
Wilmington 22
Boydton 20
The Dalles 18
Bremen 17
Columbus 17
Atlanta 15
Dong Ket 15
Hong Kong 15
Lagos 15
Messina 15
Orem 15
Denver 14
Toronto 14
Warsaw 14
Montreal 13
Seattle 13
Baghdad 12
London 12
Turku 12
Stockholm 11
Phoenix 10
Salerno 10
Abuja 9
Amsterdam 9
Brooklyn 9
Civitavecchia 9
Florence 9
Mexico City 9
Poplar 9
Pozzallo 9
Viagrande 9
Da Nang 8
Frankfurt am Main 8
Gravina di Catania 8
Hebei 8
Helsinki 8
Johannesburg 8
Lappeenranta 8
Port Harcourt 8
San Francisco 8
Aci Catena 7
Brno 7
Chennai 7
Fortaleza 7
Gela 7
Goiânia 7
Ottawa 7
Saint Petersburg 7
Siracusa 7
Turin 7
Washington 7
Barcelona 6
Cotonou 6
Ferrara di Monte Baldo 6
Foggia 6
Garbagnate Milanese 6
Lahore 6
Mumbai 6
Reggio Calabria 6
Tashkent 6
Boston 5
Totale 4.985
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Nome #
Haloperidol drug repurposing unveils ferroptosis involvement in breast cancer cells 301
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer 199
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent in Vitro Antiproliferative Activity 195
[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor 193
Combination of heme oxygenase-1 inhibition and sigma receptor modulation for anticancer activity 192
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells 187
Glucose-impaired Corneal Re-epithelialization Is Promoted by a Novel Derivate of Dimethyl Fumarate 183
Solid lipid nanoparticles loading idebenone ester with pyroglutamic acid: In vitro antioxidant activity and in vivo topical efficacy 160
A computer-aided approach to identify novel Leishmania major protein disulfide isomerase inhibitors for treatment of leishmaniasis 158
Combination of heme oxygenase-1 inhibitors and temozolomide to improve the anticancer effect in glioblastoma 149
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors 145
Chromatograpic resolution of phenylethanolic-azole racemic compounds highlighted stereoselective inhibition of heme oxygenase-1 by (R)-enantiomers 143
Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells 139
Evaluation of the anticancer effects exerted by 5-fluorouracil and heme oxygenase-1 inhibitor hybrids in HTC116 colorectal cancer cells 139
Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 138
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 138
Development of New Benzylpiperazine Derivatives as σ1Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects 138
ATTIVITÀ ANTIOSSIDANTE IN VITRO DI DERIVATI DELL’IDEBENONE 136
New arylethanolimidazole derivatives as HO-1 inhibitors with cytotoxicity against MCF-7 breast cancer cells 135
Design and synthesis of new homo and hetero bis-piperazinyl-1- propanone derivatives as 5-HT7R selective ligands over 5-HT1AR 134
Correction to Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 131
Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo 129
Ginseng and heme oxygenase-1: The link between an old herb and a new protective system 127
Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain 125
Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT7 and 5-HT1A receptor ligands 125
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation 125
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines 122
In vitro antioxidant and anti-glycation activity of resveratrol and its novel triester with trolox 121
Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation 120
The analgesic potential of glycosides derived from medicinal plants 120
Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective 120
Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia 120
Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects 119
Mutual Prodrugs of 5-Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs 119
Synthesis and in vitro antioxidant activity of a novel idebenone ester with pyroglutamic acid. 117
Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents 117
Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats 115
Characterization of sigma 1 receptor antagonist CM-304 and its analog, AZ-66: Novel therapeutics against allodynia and induced pain 114
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 111
Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands 108
Divergent cytotoxic and metabolically stimulative functions of sigma-2 receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives 107
Benzimidazolone-based selective σ2 receptor ligands: Synthesis and pharmacological evaluation 106
Discovery of 3-(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligands 106
New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7 and 5-HT1A receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies 104
Lipid nanoparticles traverse non-corneal path to reach the posterior eye segment: In vivo evidence 102
Examination of the Novel Sigma‐1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti‐Allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use 99
Bioanalytical method development and pharmacokinetics of MCI-92, a sigma-1 receptor ligand 98
Synthesis and in Vitro Evaluation of CAPE Derivatives as Ferroptosis Inducers in Triple Negative Breast Cancer 94
New alkylpiperazines as 5-HT7R ligands 81
The Inhibition of Neuropathic Pain Incited by Nerve Injury and Accompanying Mood Disorders by New Heme Oxygenase-1 Inducers: Mechanisms Implicated 80
Lauric acid-based thermosensitive delivery system for the treatment of head and neck squamous cell carcinoma 79
Exploring 1-adamantanamine as an alternative amine moiety for metabolically labile azepane ring in newly synthesized benzo[d]thiazol-2(3H)one σ receptor ligands 78
In vitro and in silico analysis of imatinib analogues as anti- Trypanosoma cruzi drug candidates 77
Strategies to improve resveratrol systemic and topical bioavailability: An update 77
Novel selective ligands for the serotonergic 5-HT7 receptor: tricyclic derivatives Bearing the pyrimido-4(3H)-one ring 72
Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT1A and 5-HT7 receptor ligands 72
New thienopyrimidine and quinazoline derivatives as potential 5-HT7 receptor ligands. 69
New alkylpiperazines as 5-HT7R ligands 68
New homo and hetero bis-arylpiperazine and bis-benzylpiperazine derivatives as 5-HT7R selective ligands: design and synthesis 68
UPLC-MS/MS method for the quantification of MCI-77, a novel sigma-1 receptor ligand, and its application to pharmacokinetic studies 67
New 5-Ht7 Receptor Ligands As Potential Antidepressant Agents. 66
Thieno[3,2-d]pyrimidine as a scaffold for 5-HT7 receptor ligands 62
Laboratory-Scale Semipreparative Enantioresolution of Phenylethanolic-Azole Heme Oxygenase-1 Inhibitors 58
Novel benzothiazolones and benzoxazolones-based σ receptor ligands: synthesis and preliminary pharmacological evaluation against allodynia 50
Semi-Synthetic H2S Releasing Compounds with Antioxidant and Vasorelaxant Properties 34
The Sigma1 receptor antagonist CM304 potentiates the antinociceptive effects of the cannabinoid receptor agonist delta9-tetrahydrocannabinol in rats and mice 14
Beyond conventional 5-Fluorouracil: Recent medicinal chemistry strategies to enhance its anticancer efficacy 12
Design development and in vitro evaluation of mutual prodrugs combining 5-fluorouracil and HO-1 inhibitor with antiproliferative effect. 10
New mutual prodrugs of 5-fluorouracil and heme oxygenase 1 inhibitor with antiproliferative effects on breast cancer cells 9
Development of 5-fluorouracil and heme oxygenase 1 inhibitor mutual prodrugs as an innovative anticancer strategy 8
Design and synthesis of imidazole and triazole derivatives as new heme oxygenase 1 inhibitors 5
Synthesis of new 5-fluorouracil and heme oxygenase 1 inhibitor mutual prodrugs with antiproliferative effects. 3
Totale 7.742
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Categoria #
all - tutte 25.119
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 25.119
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022471 0 57 59 16 67 17 69 33 17 27 11 98
2022/2023857 69 74 38 116 67 126 3 141 147 15 52 9
2023/2024439 20 52 21 22 48 110 5 28 1 18 65 49
2024/20251.659 24 255 67 134 294 150 168 51 126 144 138 108
2025/20263.537 216 150 733 190 475 710 302 94 251 197 157 62
2026/2027216 150 66 0 0 0 0 0 0 0 0 0 0
Totale 7.742