IRIS
PREZZAVENTO, Orazio
 Distribuzione geografica
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Continente #
NA - Nord America 7.726
EU - Europa 3.751
AS - Asia 3.363
SA - Sud America 610
AF - Africa 568
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 3
Totale 16.032
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Nazione #
US - Stati Uniti d'America 7.433
SG - Singapore 1.670
RU - Federazione Russa 1.156
CN - Cina 890
IT - Italia 785
IE - Irlanda 538
BR - Brasile 491
CI - Costa d'Avorio 340
UA - Ucraina 338
VN - Vietnam 321
DE - Germania 272
CA - Canada 223
FR - Francia 184
GB - Regno Unito 119
SN - Senegal 83
KR - Corea 76
NG - Nigeria 72
FI - Finlandia 67
IN - India 67
SE - Svezia 63
BD - Bangladesh 54
JP - Giappone 54
AR - Argentina 47
PL - Polonia 40
ES - Italia 39
MX - Messico 38
ID - Indonesia 36
HK - Hong Kong 35
IQ - Iraq 31
NL - Olanda 31
TR - Turchia 28
UZ - Uzbekistan 24
CH - Svizzera 22
ZA - Sudafrica 19
AT - Austria 18
EC - Ecuador 18
GR - Grecia 14
CO - Colombia 13
MA - Marocco 13
VE - Venezuela 13
BE - Belgio 12
CZ - Repubblica Ceca 12
KE - Kenya 12
CL - Cile 10
LB - Libano 10
JM - Giamaica 9
TN - Tunisia 9
AU - Australia 8
EG - Egitto 8
IR - Iran 8
PK - Pakistan 8
HU - Ungheria 7
AL - Albania 6
ET - Etiopia 6
LT - Lituania 6
NP - Nepal 6
PY - Paraguay 6
CR - Costa Rica 5
RS - Serbia 5
SA - Arabia Saudita 5
UY - Uruguay 5
DO - Repubblica Dominicana 4
JO - Giordania 4
KG - Kirghizistan 4
KZ - Kazakistan 4
AE - Emirati Arabi Uniti 3
AZ - Azerbaigian 3
BO - Bolivia 3
HN - Honduras 3
HR - Croazia 3
IL - Israele 3
MY - Malesia 3
OM - Oman 3
PE - Perù 3
PH - Filippine 3
TH - Thailandia 3
BA - Bosnia-Erzegovina 2
BB - Barbados 2
BG - Bulgaria 2
DZ - Algeria 2
EU - Europa 2
NZ - Nuova Zelanda 2
RO - Romania 2
SV - El Salvador 2
SY - Repubblica araba siriana 2
AG - Antigua e Barbuda 1
AO - Angola 1
BY - Bielorussia 1
BZ - Belize 1
DK - Danimarca 1
DM - Dominica 1
GA - Gabon 1
GE - Georgia 1
GH - Ghana 1
GT - Guatemala 1
GY - Guiana 1
KH - Cambogia 1
LK - Sri Lanka 1
LV - Lettonia 1
MD - Moldavia 1
Totale 16.020
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Città #
Dallas 1.210
Singapore 997
Chandler 780
Santa Clara 759
Dublin 537
Moscow 512
San Jose 487
Jacksonville 418
Chicago 404
Ashburn 394
Abidjan 340
Boardman 212
Catania 187
Houston 183
Nanjing 177
Beijing 154
Andover 149
Cambridge 149
Lawrence 149
Toronto 140
Civitanova Marche 136
Lauterbourg 133
Los Angeles 133
Munich 113
Dakar 83
Des Moines 83
Ho Chi Minh City 83
Dong Ket 82
Seoul 76
Wilmington 71
New York 68
San Mateo 61
Council Bluffs 60
Grafing 60
Bremen 56
The Dalles 54
Nanchang 52
São Paulo 51
Tokyo 51
Hanoi 50
Shenyang 50
Helsinki 49
Buffalo 48
Columbus 46
Hefei 38
Saint Petersburg 37
Jiaxing 36
Changsha 35
Lagos 33
Warsaw 33
Hong Kong 32
Ottawa 32
Tianjin 31
Hebei 28
Abuja 26
Orem 26
Rio de Janeiro 26
Atlanta 24
Jakarta 24
Falls Church 21
London 20
Montreal 20
Phoenix 20
Brooklyn 19
Denver 18
Mexico City 18
Rome 18
Leawood 16
Milan 16
Washington 16
Belo Horizonte 15
Madrid 15
Naples 15
Da Nang 14
San Francisco 14
Seattle 14
Baghdad 13
Norwalk 13
Port Harcourt 13
Pune 13
Centro 12
Dhaka 12
Stockholm 12
Tashkent 12
Brussels 11
Chennai 11
Frankfurt am Main 11
Jinan 11
Johannesburg 11
Ningbo 11
Palermo 11
Amsterdam 10
Guangzhou 10
Kunming 9
Manchester 9
Poplar 9
Quito 9
Zhengzhou 9
Ardabil 8
Augusta 8
Totale 11.095
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Nome #
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 322
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors 299
(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury 208
Antioxidant properties and pharmacokinetic studies of new selective σ1 bifunctional ligands 207
1-Phenyl-3azabicyclo[3.1.0]hexane derivatives as new ligands for sigma receptors 207
(+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia 207
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 201
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells 200
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer 199
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 186
1,3-Diossolani e analoghi aperti come nuovi ligandi per il recettore Sigma 178
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 177
HALOPERIDOL METABOLITE II VALPROATE ESTER: ANTIANGIOGENIC ACTIVITY IN HUMAN MICROVASCULAR RETINAL ENDOTHELIAL CELLS 176
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells 175
Antioxidant activity of (+)-Pentazocine on activated microglia 174
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 174
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties 166
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties 165
Benzomorphan-based opioid ligands with mixed m agonist/d antagonist activity 161
R- ed S-LP2: sintesi, molecular docking e valutazione farmacologica 160
A novel and selective σ1/2 receptor ligand (PO680C): binding properties and expression of tissue transglutaminase 158
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma 158
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review 156
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 154
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 153
Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity 151
Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion 151
Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma 149
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors 149
Dual MOR/DOR agonist benzomorphan-based compounds for pain relief 148
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 147
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats 145
Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands. 144
Development of novel LP1-based analogues with enhanced delta opioid receptor profile 144
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 141
(+)-MR200 derivatives as potenzial new selective ligands 140
Development of New Benzylpiperazine Derivatives as σ1Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects 135
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 134
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 133
New selective Sigma-1/HDACi prodrugs for neurodegenerative disorders 131
Development of NO-releasing sigma receptor hybrids as anticancer agents 130
Tumor Targeting Sigma Receptor Ligands: Development of New Molecular Hybrids as Anticancer Therapeutics 126
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 125
Sigma-2 receptor ligands QSAR model dataset 125
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 125
Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase 124
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation 124
Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands 120
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines 120
Novel Sigma Receptors Ligands-Nitric Oxide Photodonor: Molecular Hybrids for Double-Targeted Antiproliferative Effect 117
Synthesis of (+)-(1'R,2'S) and (1'S,2'R)-6,11 -dimethyl-1,2,3,4,5,6-hexahydro-3-[[2'-(alkoxycarbonyl)-2'- phenylcycloprophy]methyl]-2,6-methano-3-benzazocin-8-ol. Comparison of the affinities for sigma(1) and opioid receptors with in the diastereoisomeric MPCB and CCB 115
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 115
Synthesis and pharmacological evaluation of MRJF4 as new potential anticancer tool 115
Haloperidol Metabolite II Valproate Ester: Antiangiogenic Activity in Human Microvascular Retinal Endothelial Cells 115
S2RSLDB: A comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands 112
CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites 112
Synthesis of Novel Benzylpiperazine Derivatives as Ligands for the σ1 Receptor 111
Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands 111
Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites 111
Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma 110
In-vitro evaluation of a new benzomorphan-based ligand 109
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain 109
Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo 106
Novel Sigma Receptor Ligands: Synthesis and Biological Profile 104
A NOVEL MIMETIC OF OPIOID TYRAMINE ACTIVE CONFORMATION 104
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 104
Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation 104
Evaluation of N-substitution in 6,7-benzomorphan compounds 103
CCB - A novel analog of MPCB with high binding affinity and specific kappa opioid receptor agonist 103
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures 103
Nonpeptide Analogues of Dynorphin A(1-8): Design, Synthesis, and Pharmacological Evaluation of k-Selective Agonists 101
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 101
Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. 100
Evaluation of (–)-MR22 a novel sigma-1 receptor ligand on lesion-induced memory dysfunctions in the rat 100
Pain management: new long-acting opioid ligands 100
Synthesis and spasmolytic action of 2-substituted thienopyrimidin-4-one derivatives 99
New developments in opioid receptors ligands 99
From agonist to antagonist profile in LP1 analogues through the introduction of different N-substituents in benzomorphan-based ligands 99
Specific κ opioid receptor agonists 98
Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D-QSAR Coupled to Scaffold-Hopping Analysis 95
Synthesis of (+) and (−)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as probe for sigma-1 and sigma-2 binding sites 94
DISCOVERY OF NEW SIGMA-2 RECEPTOR AGONIST ENDOWED WITH ANTIPROLIFERATIVE ACTIVITY 92
Modulation of opioid receptor profile of LP1 analogues through the introduction of different N-substituents 91
New benzomorphan derivatives of MPCB as MOP and KOP receptor ligands 91
Synthesis of MRJF4 enentiomers and evaluation of proapoptotic and cytotoxic effects in cancer cell lines 90
NOVEL 1-PHENYL-2-{[(2,6,6-TRIMETHYLBICYCLO[3.1.1]HEPT-3-YL)AMINO]METHYL}CYCLOPROPANECARBOXYLATE DIASTEREOISOMERS AS POTENT AND ENANTIOSELECTIVE SIGMA-1 AND SIGMA-2 LIGANDS 89
Opioid and sigma receptor studies. New developments in the design of selective sigma ligands 89
Synthesis of (+)- and (-)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as high affinity probes for sigma1 and sigma2 binding sites 89
Opioid multiple ligands 88
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors 88
Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries 87
Multitarget MOR/DOR antinociceptive ligands as useful profile in pain management: synthesis and pharmacological studies of 6,7-benzomorphan-based LP2 and its isomers 87
Synthesis and pharmacological evaluation of potent and enantioselective sigma-1 and sigma-2 ligands 87
Sigma receptor binding profile of a series of analgesic tropane derivatives 87
Benzyl-tropanyl esters and ethers of phenoxypropionic acid as novel sigma receptor ligands 86
Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents 86
Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-​1 86
Effect of sigma ligands, (+)-MR200 anf (-)-MRV3, on DMPC biomembrane model: DSC study 86
Synthesis and pharmacological evaluation of novel series of (+)-MR-200 derivatives 85
New bifunctional antioxidant/σ1 agonist ligands: preliminary chemico-physical and biological evaluation 84
Totale 13.029
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Categoria #
all - tutte 53.918
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 53.918
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.161 141 154 22 17 182 17 178 34 89 13 30 284
2022/20232.096 185 138 24 274 190 351 0 351 483 16 60 24
2023/2024963 51 199 32 29 41 247 15 65 0 22 180 82
2024/20253.276 34 618 163 237 638 337 203 159 233 250 195 209
2025/20266.442 406 197 1.307 390 989 1.269 711 112 378 367 177 139
2026/202753 53 0 0 0 0 0 0 0 0 0 0 0
Totale 16.438