IRIS
PREZZAVENTO, Orazio
 Distribuzione geografica
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Continente #
NA - Nord America 6.286
EU - Europa 2.371
AS - Asia 1.982
AF - Africa 452
SA - Sud America 432
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 2
Totale 11.535
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Nazione #
US - Stati Uniti d'America 6.077
SG - Singapore 883
IT - Italia 733
CN - Cina 715
IE - Irlanda 535
BR - Brasile 385
CI - Costa d'Avorio 339
UA - Ucraina 330
DE - Germania 258
CA - Canada 186
RU - Federazione Russa 158
VN - Vietnam 115
SN - Senegal 83
GB - Regno Unito 70
FI - Finlandia 59
SE - Svezia 57
IN - India 44
JP - Giappone 42
FR - Francia 35
ID - Indonesia 28
KR - Corea 26
BD - Bangladesh 21
CH - Svizzera 20
NL - Olanda 20
UZ - Uzbekistan 19
AR - Argentina 18
IQ - Iraq 18
ES - Italia 17
PL - Polonia 17
HK - Hong Kong 16
AT - Austria 14
MX - Messico 14
TR - Turchia 13
GR - Grecia 12
BE - Belgio 11
EC - Ecuador 11
CZ - Repubblica Ceca 10
IR - Iran 8
MA - Marocco 8
AU - Australia 7
LB - Libano 7
TN - Tunisia 7
ZA - Sudafrica 6
VE - Venezuela 5
CO - Colombia 4
HU - Ungheria 4
JM - Giamaica 4
SA - Arabia Saudita 4
EG - Egitto 3
KE - Kenya 3
KZ - Kazakistan 3
NP - Nepal 3
PK - Pakistan 3
UY - Uruguay 3
AE - Emirati Arabi Uniti 2
AL - Albania 2
AZ - Azerbaigian 2
BG - Bulgaria 2
CL - Cile 2
ET - Etiopia 2
EU - Europa 2
IL - Israele 2
JO - Giordania 2
KG - Kirghizistan 2
NZ - Nuova Zelanda 2
PY - Paraguay 2
RO - Romania 2
AO - Angola 1
BB - Barbados 1
BO - Bolivia 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
GE - Georgia 1
GT - Guatemala 1
HN - Honduras 1
HR - Croazia 1
LK - Sri Lanka 1
LT - Lituania 1
ME - Montenegro 1
NC - Nuova Caledonia 1
PE - Perù 1
PH - Filippine 1
RS - Serbia 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
Totale 11.535
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Città #
Dallas 1.202
Chandler 775
Santa Clara 733
Singapore 545
Dublin 534
Jacksonville 417
Chicago 397
Abidjan 339
Boardman 212
Ashburn 195
Catania 185
Nanjing 178
Houston 164
Andover 149
Cambridge 149
Lawrence 148
Civitanova Marche 137
Toronto 133
Munich 112
Beijing 99
Dakar 83
Des Moines 82
Dong Ket 82
Wilmington 72
Grafing 61
San Mateo 61
Los Angeles 57
Bremen 56
The Dalles 54
Council Bluffs 52
Nanchang 52
Shenyang 49
Columbus 47
Helsinki 43
Tokyo 42
Jiaxing 37
Saint Petersburg 37
Changsha 34
Hefei 32
Ottawa 32
Tianjin 31
Hebei 27
Seoul 26
Rio de Janeiro 25
São Paulo 25
Moscow 24
Jakarta 22
Falls Church 21
New York 20
Leawood 16
Naples 15
Washington 15
Hong Kong 14
Milan 14
San Francisco 14
Belo Horizonte 13
Norwalk 13
Pune 13
Rome 13
Centro 12
Warsaw 12
Brussels 11
Hanoi 11
Ho Chi Minh City 11
Jinan 11
Ningbo 11
Phoenix 11
Palermo 10
Augusta 9
Dhaka 9
Guangzhou 9
Kunming 9
Madrid 9
Seattle 9
Zhengzhou 9
Ardabil 8
Atlanta 8
Baghdad 8
Brooklyn 8
Den Haag 8
Tappahannock 8
Aci Catena 7
Brno 7
Jyväskylä 7
London 7
Siracusa 7
Tashkent 7
Turku 7
Brasília 6
Fuzhou 6
Groningen 6
Redwood City 6
Ann Arbor 5
Bari 5
Campinas 5
Chennai 5
Curitiba 5
Hangzhou 5
Osio Sotto 5
Paris 5
Totale 8.553
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Nome #
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 265
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors 239
Antioxidant properties and pharmacokinetic studies of new selective σ1 bifunctional ligands 154
1-Phenyl-3azabicyclo[3.1.0]hexane derivatives as new ligands for sigma receptors 149
(+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia 148
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells 147
HALOPERIDOL METABOLITE II VALPROATE ESTER: ANTIANGIOGENIC ACTIVITY IN HUMAN MICROVASCULAR RETINAL ENDOTHELIAL CELLS 144
(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury 144
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer 141
1,3-Diossolani e analoghi aperti come nuovi ligandi per il recettore Sigma 137
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 132
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 122
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 121
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 120
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells 118
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties 117
R- ed S-LP2: sintesi, molecular docking e valutazione farmacologica 116
A novel and selective σ1/2 receptor ligand (PO680C): binding properties and expression of tissue transglutaminase 112
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 112
Antioxidant activity of (+)-Pentazocine on activated microglia 110
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma 110
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 109
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 107
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 107
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review 106
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties 106
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors 105
Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity 103
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 103
Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands. 101
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation 101
Sigma-2 receptor ligands QSAR model dataset 100
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats 99
Development of novel LP1-based analogues with enhanced delta opioid receptor profile 98
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines 98
Benzomorphan-based opioid ligands with mixed m agonist/d antagonist activity 97
Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma 96
CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites 96
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 93
Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase 92
Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands 92
Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion 92
Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo 91
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 91
Dual MOR/DOR agonist benzomorphan-based compounds for pain relief 90
S2RSLDB: A comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands 89
CCB - A novel analog of MPCB with high binding affinity and specific kappa opioid receptor agonist 88
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 88
SYNTHESIS OF (+)-(1'R,2'S) AND (1'S,2'R)-6,11-DIMETHYL-1,2,3,4,5,6-HEXAHYDRO-3-[[2'-(ALKOXYCARBONYL)-2'-PHENYLCYCLOPROPYL]METHYL]-2,6-METHANO-3-BENZAZOCIN-8-OL. COMPARISON OF THE AFFINITIES FOR SIGMA 1 AND OPIOID RECEPTORS WITHIN THE DIASTEREOISOMERIC MPCB AND CCB 87
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 85
Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites 85
Development of New Benzylpiperazine Derivatives as σ1Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects 85
Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. 83
Nonpeptide Analogues of Dynorphin A(1-8): Design, Synthesis, and Pharmacological Evaluation of k-Selective Agonists 83
Tumor Targeting Sigma Receptor Ligands: Development of New Molecular Hybrids as Anticancer Therapeutics 83
Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma 83
New selective Sigma-1/HDACi prodrugs for neurodegenerative disorders 83
SYNTHESIS AND SPASMOLYTIC ACTIVITY OF 2-SUBSTITUTED THIENOPYRIMIDIN-4-ONE DERIVATIVES 82
Synthesis of Novel Benzylpiperazine Derivatives as Ligands for the σ1 Receptor 81
Novel Sigma Receptors Ligands-Nitric Oxide Photodonor: Molecular Hybrids for Double-Targeted Antiproliferative Effect 81
(+)-MR200 derivatives as potenzial new selective ligands 80
Development of NO-releasing sigma receptor hybrids as anticancer agents 80
Synthesis and pharmacological evaluation of MRJF4 as new potential anticancer tool 79
Evaluation of (–)-MR22 a novel sigma-1 receptor ligand on lesion-induced memory dysfunctions in the rat 79
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 79
Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation 79
Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands 78
Novel Sigma Receptor Ligands: Synthesis and Biological Profile 77
Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D-QSAR Coupled to Scaffold-Hopping Analysis 76
Specific kappa opioid receptor agonists 75
From agonist to antagonist profile in LP1 analogues through the introduction of different N-substituents in benzomorphan-based ligands 74
Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries 74
New developments in opioid receptors ligands 73
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures 73
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain 73
Benzyl-tropanyl esters and ethers of phenoxypropionic acid as novel sigma receptor ligands 72
A NOVEL MIMETIC OF OPIOID TYRAMINE ACTIVE CONFORMATION 72
Haloperidol Metabolite II Valproate Ester: Antiangiogenic Activity in Human Microvascular Retinal Endothelial Cells 72
In-vitro evaluation of a new benzomorphan-based ligand 72
Synthesis and pharmacological evaluation of potent and enantioselective sigma-1 and sigma-2 ligands 72
Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-​1 71
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 70
Synthesis of (+)- and (-)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as high affinity probes for sigma1 and sigma2 binding sites 70
Novel methyl-2-[4-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-phenylcyclopropane-carboxylate derivatives as sigma-1 and sigma-2 receptor ligands 69
New benzomorphan derivatives of MPCB as MOP and KOP receptor ligands 69
Sigma receptor binding profile of a series of analgesic tropane derivatives 69
Opioid multiple ligands 68
NOVEL 1-PHENYL-2-{[(2,6,6-TRIMETHYLBICYCLO[3.1.1]HEPT-3-YL)AMINO]METHYL}CYCLOPROPANECARBOXYLATE DIASTEREOISOMERS AS POTENT AND ENANTIOSELECTIVE SIGMA-1 AND SIGMA-2 LIGANDS 67
Modulation of opioid receptor profile of LP1 analogues through the introduction of different N-substituents 66
Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents 66
New bifunctional antioxidant/σ1 agonist ligands: preliminary chemico-physical and biological evaluation 65
Sigma receptors and tissue transglutaminase in primary rat astroglial cell cultures 65
Evaluation of N-substitution in 6,7-benzomorphan compounds 65
Pain management: new long-acting opioid ligands 65
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors 65
New " Receptor Ligands with Neuroprotective Effect: Synthesis and Resolution of cis-(±)-Methyl (1R,2S/1S,2R)-2-[(4-Hydroxy-4- phenylpiperidin-1-yl)methyl]-1-(4- methylphenyl)cyclopropanecarboxylate [(±)-PPCC] 64
Opioid and sigma receptor studies. New developments in the design of selective sigma ligands 64
DISCOVERY OF NEW SIGMA-2 RECEPTOR AGONIST ENDOWED WITH ANTIPROLIFERATIVE ACTIVITY 63
Synthesis of (+) and (−)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as probe for sigma-1 and sigma-2 binding sites 63
From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands 63
Totale 9.433
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Categoria #
all - tutte 42.508
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 42.508
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021726 0 0 0 34 230 15 87 5 114 2 122 117
2021/20221.162 141 154 22 18 182 17 178 35 89 13 30 283
2022/20232.082 185 138 25 272 189 349 0 347 478 16 59 24
2023/2024964 51 199 33 29 41 249 15 63 0 22 180 82
2024/20253.285 33 621 164 238 640 338 203 159 234 251 195 209
2025/20261.990 407 197 1.308 78 0 0 0 0 0 0 0 0
Totale 11.939