IRIS
PREZZAVENTO, Orazio
 Distribuzione geografica
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Continente #
NA - Nord America 6.669
EU - Europa 3.152
AS - Asia 2.820
SA - Sud America 525
AF - Africa 458
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 2
Totale 13.636
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Nazione #
US - Stati Uniti d'America 6.436
SG - Singapore 1.519
RU - Federazione Russa 883
CN - Cina 822
IT - Italia 741
IE - Irlanda 535
BR - Brasile 449
CI - Costa d'Avorio 339
UA - Ucraina 330
DE - Germania 258
CA - Canada 196
VN - Vietnam 178
SN - Senegal 83
GB - Regno Unito 82
SE - Svezia 63
FI - Finlandia 59
IN - India 51
JP - Giappone 46
FR - Francia 37
AR - Argentina 33
ID - Indonesia 31
PL - Polonia 27
BD - Bangladesh 26
KR - Corea 26
MX - Messico 25
NL - Olanda 25
ES - Italia 24
CH - Svizzera 20
IQ - Iraq 20
UZ - Uzbekistan 19
HK - Hong Kong 18
TR - Turchia 17
AT - Austria 15
EC - Ecuador 14
GR - Grecia 12
BE - Belgio 11
CZ - Repubblica Ceca 10
ZA - Sudafrica 10
MA - Marocco 9
CO - Colombia 8
IR - Iran 8
VE - Venezuela 8
AU - Australia 7
LB - Libano 7
TN - Tunisia 7
RS - Serbia 5
HU - Ungheria 4
JM - Giamaica 4
PK - Pakistan 4
PY - Paraguay 4
SA - Arabia Saudita 4
UY - Uruguay 4
AE - Emirati Arabi Uniti 3
EG - Egitto 3
IL - Israele 3
KE - Kenya 3
KZ - Kazakistan 3
NP - Nepal 3
AL - Albania 2
AZ - Azerbaigian 2
BG - Bulgaria 2
CL - Cile 2
DO - Repubblica Dominicana 2
ET - Etiopia 2
EU - Europa 2
JO - Giordania 2
KG - Kirghizistan 2
LT - Lituania 2
NZ - Nuova Zelanda 2
PE - Perù 2
RO - Romania 2
AO - Angola 1
BB - Barbados 1
BO - Bolivia 1
CR - Costa Rica 1
DK - Danimarca 1
DZ - Algeria 1
GE - Georgia 1
GT - Guatemala 1
HN - Honduras 1
HR - Croazia 1
LK - Sri Lanka 1
ME - Montenegro 1
NC - Nuova Caledonia 1
OM - Oman 1
PH - Filippine 1
SV - El Salvador 1
TH - Thailandia 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
Totale 13.636
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Città #
Dallas 1.205
Singapore 885
Chandler 775
Santa Clara 735
Dublin 534
Jacksonville 417
Moscow 417
Chicago 401
Abidjan 339
Ashburn 273
Boardman 212
Catania 185
Nanjing 178
Houston 173
Andover 149
Cambridge 149
Lawrence 148
Beijing 141
Civitanova Marche 137
Toronto 133
Munich 112
Los Angeles 109
Dakar 83
Des Moines 82
Dong Ket 82
Wilmington 72
Grafing 61
San Mateo 61
Bremen 56
The Dalles 54
Council Bluffs 52
Nanchang 52
New York 50
Shenyang 49
Columbus 47
Tokyo 46
Helsinki 43
Ho Chi Minh City 42
São Paulo 41
Hefei 38
Jiaxing 37
Saint Petersburg 37
Buffalo 36
Changsha 35
Ottawa 32
Tianjin 31
Hebei 27
Rio de Janeiro 26
Seoul 26
Jakarta 22
Falls Church 21
Warsaw 21
Hanoi 18
Atlanta 16
Hong Kong 16
Leawood 16
Brooklyn 15
Milan 15
Naples 15
Washington 15
Belo Horizonte 14
Rome 14
San Francisco 14
San Jose 14
Denver 13
Norwalk 13
Phoenix 13
Pune 13
Centro 12
Brussels 11
Jinan 11
Ningbo 11
Dhaka 10
Mexico City 10
Montreal 10
Orem 10
Palermo 10
Seattle 10
Augusta 9
Guangzhou 9
Kunming 9
Madrid 9
Zhengzhou 9
Amsterdam 8
Ardabil 8
Baghdad 8
Den Haag 8
London 8
Poplar 8
Stockholm 8
Tappahannock 8
Aci Catena 7
Boston 7
Brno 7
Campinas 7
Chennai 7
Jyväskylä 7
Paris 7
Siracusa 7
Tashkent 7
Totale 9.680
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Nome #
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 295
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors 276
Antioxidant properties and pharmacokinetic studies of new selective σ1 bifunctional ligands 186
(+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia 185
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells 182
(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury 177
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 177
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer 175
1-Phenyl-3azabicyclo[3.1.0]hexane derivatives as new ligands for sigma receptors 175
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 161
1,3-Diossolani e analoghi aperti come nuovi ligandi per il recettore Sigma 161
HALOPERIDOL METABOLITE II VALPROATE ESTER: ANTIANGIOGENIC ACTIVITY IN HUMAN MICROVASCULAR RETINAL ENDOTHELIAL CELLS 155
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 155
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 150
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells 148
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties 143
R- ed S-LP2: sintesi, molecular docking e valutazione farmacologica 139
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma 139
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 138
A novel and selective σ1/2 receptor ligand (PO680C): binding properties and expression of tissue transglutaminase 137
Antioxidant activity of (+)-Pentazocine on activated microglia 136
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties 135
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors 134
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review 132
Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma 131
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 130
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 128
Benzomorphan-based opioid ligands with mixed m agonist/d antagonist activity 127
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats 127
Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity 126
Development of novel LP1-based analogues with enhanced delta opioid receptor profile 125
Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion 120
Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands. 119
Dual MOR/DOR agonist benzomorphan-based compounds for pain relief 119
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 116
Sigma-2 receptor ligands QSAR model dataset 113
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 112
(+)-MR200 derivatives as potenzial new selective ligands 111
Development of New Benzylpiperazine Derivatives as σ1Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects 111
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 110
New selective Sigma-1/HDACi prodrugs for neurodegenerative disorders 110
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation 109
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 107
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 105
Tumor Targeting Sigma Receptor Ligands: Development of New Molecular Hybrids as Anticancer Therapeutics 104
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines 104
Development of NO-releasing sigma receptor hybrids as anticancer agents 104
Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase 101
CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites 101
Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands 99
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 98
Synthesis and pharmacological evaluation of MRJF4 as new potential anticancer tool 98
Haloperidol Metabolite II Valproate Ester: Antiangiogenic Activity in Human Microvascular Retinal Endothelial Cells 98
Novel Sigma Receptors Ligands-Nitric Oxide Photodonor: Molecular Hybrids for Double-Targeted Antiproliferative Effect 98
Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands 98
Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites 98
Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo 97
Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma 96
S2RSLDB: A comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands 96
SYNTHESIS OF (+)-(1'R,2'S) AND (1'S,2'R)-6,11-DIMETHYL-1,2,3,4,5,6-HEXAHYDRO-3-[[2'-(ALKOXYCARBONYL)-2'-PHENYLCYCLOPROPYL]METHYL]-2,6-METHANO-3-BENZAZOCIN-8-OL. COMPARISON OF THE AFFINITIES FOR SIGMA 1 AND OPIOID RECEPTORS WITHIN THE DIASTEREOISOMERIC MPCB AND CCB 95
A NOVEL MIMETIC OF OPIOID TYRAMINE ACTIVE CONFORMATION 93
CCB - A novel analog of MPCB with high binding affinity and specific kappa opioid receptor agonist 93
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain 93
Nonpeptide Analogues of Dynorphin A(1-8): Design, Synthesis, and Pharmacological Evaluation of k-Selective Agonists 91
In-vitro evaluation of a new benzomorphan-based ligand 91
Synthesis of Novel Benzylpiperazine Derivatives as Ligands for the σ1 Receptor 90
Novel Sigma Receptor Ligands: Synthesis and Biological Profile 89
Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. 88
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 88
Pain management: new long-acting opioid ligands 87
Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation 87
SYNTHESIS AND SPASMOLYTIC ACTIVITY OF 2-SUBSTITUTED THIENOPYRIMIDIN-4-ONE DERIVATIVES 86
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 85
Evaluation of (–)-MR22 a novel sigma-1 receptor ligand on lesion-induced memory dysfunctions in the rat 84
Evaluation of N-substitution in 6,7-benzomorphan compounds 84
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures 84
Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D-QSAR Coupled to Scaffold-Hopping Analysis 84
New developments in opioid receptors ligands 83
From agonist to antagonist profile in LP1 analogues through the introduction of different N-substituents in benzomorphan-based ligands 82
Synthesis of (+) and (−)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as probe for sigma-1 and sigma-2 binding sites 82
Specific kappa opioid receptor agonists 80
Synthesis of MRJF4 enentiomers and evaluation of proapoptotic and cytotoxic effects in cancer cell lines 79
Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries 79
Opioid and sigma receptor studies. New developments in the design of selective sigma ligands 78
New benzomorphan derivatives of MPCB as MOP and KOP receptor ligands 78
Synthesis of (+)- and (-)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as high affinity probes for sigma1 and sigma2 binding sites 78
Benzyl-tropanyl esters and ethers of phenoxypropionic acid as novel sigma receptor ligands 77
Opioid multiple ligands 77
Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-​1 77
Synthesis and pharmacological evaluation of potent and enantioselective sigma-1 and sigma-2 ligands 77
Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents 75
Sigma receptor binding profile of a series of analgesic tropane derivatives 75
NOVEL 1-PHENYL-2-{[(2,6,6-TRIMETHYLBICYCLO[3.1.1]HEPT-3-YL)AMINO]METHYL}CYCLOPROPANECARBOXYLATE DIASTEREOISOMERS AS POTENT AND ENANTIOSELECTIVE SIGMA-1 AND SIGMA-2 LIGANDS 74
Novel methyl-2-[4-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-phenylcyclopropane-carboxylate derivatives as sigma-1 and sigma-2 receptor ligands 74
DISCOVERY OF NEW SIGMA-2 RECEPTOR AGONIST ENDOWED WITH ANTIPROLIFERATIVE ACTIVITY 73
New bifunctional antioxidant/σ1 agonist ligands: preliminary chemico-physical and biological evaluation 72
Modulation of opioid receptor profile of LP1 analogues through the introduction of different N-substituents 72
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors 72
SYNTHESIS AND BINDING AFFINITY OF CIS-(-)- AND CIS-(+)-N-ETHYLENEAMINO-N-NORDEOXYMETAZOCINE AND CIS(-)-N-NORMETAZOCINE ANALOGUES AT SIGMA-1, SIGMA-2 AND KAPPA OPIOID RECEPTORS 72
From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands 72
Totale 11.187
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Categoria #
all - tutte 46.633
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.633
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021462 0 0 0 0 0 15 87 5 114 2 122 117
2021/20221.162 141 154 22 18 182 17 178 35 89 13 30 283
2022/20232.082 185 138 25 272 189 349 0 347 478 16 59 24
2023/2024964 51 199 33 29 41 249 15 63 0 22 180 82
2024/20253.285 33 621 164 238 640 338 203 159 234 251 195 209
2025/20264.091 407 197 1.308 389 989 801 0 0 0 0 0 0
Totale 14.040