IRIS
CHIECHIO, SANTINA
 Distribuzione geografica
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Continente #
NA - Nord America 5.142
AS - Asia 2.554
EU - Europa 2.480
SA - Sud America 403
AF - Africa 293
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 3
Totale 10.880
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Nazione #
US - Stati Uniti d'America 4.955
SG - Singapore 1.223
RU - Federazione Russa 709
CN - Cina 638
IT - Italia 584
BR - Brasile 339
IE - Irlanda 330
UA - Ucraina 264
HK - Hong Kong 220
VN - Vietnam 152
DE - Germania 148
CA - Canada 143
CI - Costa d'Avorio 140
FR - Francia 127
KR - Corea 75
GB - Regno Unito 69
SE - Svezia 66
IN - India 58
NG - Nigeria 54
SN - Senegal 44
BD - Bangladesh 34
PL - Polonia 31
BE - Belgio 29
JP - Giappone 28
AR - Argentina 25
NL - Olanda 23
ZA - Sudafrica 21
ES - Italia 20
TR - Turchia 20
FI - Finlandia 19
IQ - Iraq 19
MX - Messico 18
UZ - Uzbekistan 16
PK - Pakistan 15
AT - Austria 14
VE - Venezuela 14
CH - Svizzera 13
ID - Indonesia 10
EG - Egitto 9
CL - Cile 8
KE - Kenya 8
CZ - Repubblica Ceca 7
IR - Iran 7
CO - Colombia 6
JM - Giamaica 6
MA - Marocco 6
AZ - Azerbaigian 5
EC - Ecuador 5
NP - Nepal 5
PH - Filippine 5
AE - Emirati Arabi Uniti 4
BG - Bulgaria 4
CR - Costa Rica 4
EU - Europa 4
TT - Trinidad e Tobago 4
DO - Repubblica Dominicana 3
GR - Grecia 3
HN - Honduras 3
HU - Ungheria 3
JO - Giordania 3
LB - Libano 3
OM - Oman 3
PE - Perù 3
AL - Albania 2
AU - Australia 2
BH - Bahrain 2
BY - Bielorussia 2
DK - Danimarca 2
DZ - Algeria 2
KG - Kirghizistan 2
LT - Lituania 2
LV - Lettonia 2
PA - Panama 2
SA - Arabia Saudita 2
SK - Slovacchia (Repubblica Slovacca) 2
SV - El Salvador 2
TN - Tunisia 2
BB - Barbados 1
BF - Burkina Faso 1
BJ - Benin 1
BO - Bolivia 1
BS - Bahamas 1
BW - Botswana 1
ET - Etiopia 1
HR - Croazia 1
IL - Israele 1
KH - Cambogia 1
LI - Liechtenstein 1
LY - Libia 1
MG - Madagascar 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PS - Palestinian Territory 1
PT - Portogallo 1
PY - Paraguay 1
RO - Romania 1
SY - Repubblica araba siriana 1
TH - Thailandia 1
UG - Uganda 1
UY - Uruguay 1
Totale 10.879
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Città #
Dallas 709
Singapore 693
Houston 565
Santa Clara 542
Chandler 375
San Jose 373
Dublin 328
Jacksonville 281
Moscow 276
Ashburn 264
Chicago 196
Catania 187
Boardman 152
Abidjan 140
Beijing 100
Hefei 94
Cambridge 90
Lawrence 90
Andover 88
Nanjing 88
Lauterbourg 84
Toronto 83
Seoul 75
Los Angeles 68
Grafing 56
Council Bluffs 53
San Mateo 50
Wilmington 50
Ho Chi Minh City 45
Civitanova Marche 44
Dakar 44
Bremen 40
Des Moines 35
São Paulo 34
New York 30
Brussels 28
Hanoi 28
Nanchang 27
Shenyang 27
Buffalo 26
The Dalles 26
Lagos 25
Ottawa 24
Abuja 23
Hebei 23
Jiaxing 23
Naples 23
Rome 23
Columbus 21
Tokyo 21
Warsaw 20
Changsha 18
Orem 18
Saint Petersburg 18
Atlanta 17
London 17
Montreal 16
Amsterdam 15
Denver 15
Johannesburg 15
San Giovanni la Punta 15
Chennai 13
Munich 13
Tianjin 13
Brooklyn 12
Da Nang 11
Hong Kong 11
Phoenix 11
Seattle 11
Augusta 10
Baghdad 10
Haiphong 10
Jinan 10
Pune 10
Messina 9
Norwalk 9
Stockholm 9
Dong Ket 8
Falkenstein 8
Leawood 8
Misterbianco 8
Mumbai 8
Tashkent 8
Turin 8
Turku 8
Ann Arbor 7
Belo Horizonte 7
Boston 7
Caracas 7
Castelmola 7
Falls Church 7
Guangzhou 7
Poplar 7
Porto Alegre 7
Rio de Janeiro 7
Siracusa 7
Washington 7
Brasília 6
Dearborn 6
Frankfurt am Main 6
Totale 7.312
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Nome #
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation 413
N-acetylcysteine causes analgesia by activating group II metabotropic glutamate receptors 326
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 322
Metabotropic glutamate receptors and the control of chronic pain. 180
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 171
Increased heat pain tolerance but hyperalgesia to tonic inflammatory pain in the CRND8 mouse model of Alzheimer’s disease 159
Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond. 155
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 154
Intercellular communication and ion channels in neuropathic pain chronicization 152
Acetyl-L-carnitine in neuropathic pain: experimental data 148
Chronic treatment with fluoxetine induces sex-dependent analgesic effects and modulates HDAC2 and mGlu2 expression in female mice 148
Erratic expression of DNA polymerases by beta-amyloid causes neuronal death 146
A new function for ß-amyloid monomers 143
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 142
β-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: Correlation with the MAP kinase pathway 141
MOR/DOR targeting: an useful strategy in pain management 139
Central and peripheral control by endogenous opioid peptides of gastric protection in stressed-rats 135
Bone morphogenetic protein-7 delays podocyte injury due to high glucose 134
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 134
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 133
Development, Characterization, and In Vitro and In Vivo Evaluation of Benzocaine- and Lidocaine-Loaded Nanostructrured Lipid Carriers 133
LP2 e 2S-LP2: agonisti biased dual target MOR/DOR nel trattamento del dolore cronico 133
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain 132
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 131
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 131
Effects of phenformin on the proliferation of human tumor cell lines 131
Beta-Amyloid Monomer and Insulin/IGF-1 Signaling in Alzheimer's Disease 130
Activation of group-III metabotropic glutamate receptors inhibits the production of rantes in cultured astrocytes 128
Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization 127
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. 126
Effect of CCK-8 on analgesia induced by cold-restraint stress in the rat 126
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 125
Hyperalgesic activity of kisspeptin in mice 125
Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect. 123
A standardized extract prepared from red orange and lemon wastes blocks high-fat diet-induced hyperglycemia and hyperlipidemia in mice 123
Prediction of the response to citalopram and reboxetine in post-stroke depressed patients 119
L-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies 115
CURCUMIN LOADED NLC INDUCES HISTONE HYPOACETYLATION IN THE CNS AFTER INTRAPERITONEAL ADMINISTRATION IN MICE 114
Curcumin loaded NLC induces histone hypoacetylation in the CNS after intraperitoneal administration in mice. 112
Memantine and Amantadine KLVFF peptide conjugates: Synthesis, structure determination, amyloid-β interaction and effects on recognition memory in mice 110
Effect of donepezil on the proliferation and differentiation of SH-SY5Y neuroblastoma cells 110
Progress in the development of more effective and safer analgesics for pain management 110
Effects of dinorphin 1-13 on hyperalgesia induced by interleukin-1bera in the rat 108
Gender specific effects of fluoxetine, duloxetine and amitriptyline in pain behavior and spinal BDNF expression in mice 108
Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes 106
Novel neuronal targets for the acetylcholinesterase inhibitor donepezil 103
HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors 102
Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity 102
Re-use of waste products of the Citrus industry for Nutraceutical formulations with enhancement of dissolution rate and oral bioavailability 102
Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles 102
An evaluation of efficacy and safety of reboxetine in elderly patients affected by "retarded" post-stroke depression. A random, placebo-controlled study 101
Evaluation of the prophylactic efficacy of amitriptyline and citalopram, alone or in combination, in patients with comorbidity of depression, migraine, and tension-type headache 100
An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats 97
L-acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors 96
Biological activities of ß-amyloid monomers 96
Metabotropic receptors as target for drugs of potential use in the treatment of neuropathic pain 96
Exploring the Role of Hsp60 in Alzheimer's Disease and Type 2 Diabetes: Suggestion for Common Drug Targeting 96
Simultaneous activation of mu and delta opioid receptors reduces allodynia and astrocytic connexin 43 in an animal model of neuropathic pain 93
L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors 92
mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists 91
Gender specific effects of antidepressant drugs in pain behavior and spinal BDNF expression in mice 90
Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine 90
Inhibition of pain response in the formalin test by naloxone in normal- or cold-.restrained-rats 89
Epigenetic control of chronic pain mechanism 88
Multitarget MOR/DOR antinociceptive ligands as useful profile in pain management: synthesis and pharmacological studies of 6,7-benzomorphan-based LP2 and its isomers 87
Preparation and analgesic activity of Eudragit RS100 microparticles containing diflunisal 86
H3-histamine receptors and clonidine analgesia in rats 86
Estrogen stimulates beta amyloid peptide degradation through up-regulation of matrix mealloproteinases 2 and 9. 86
Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain 86
MOR/DOR Dual-Target Approach: 2S-LP2 Effects in Inflammatory and Neuropathic Pain 86
Lipid nanoparticle inclusion prevents capsaicin-induced TRPV1 defunctionalization. 83
Targeting chronic pain with epigenetic drugs: Focus on mGlu2 receptors 82
Evidence of a key-role for histamine from mast cells in the analgesic effect of clomipramine in rats 81
Histaminergic mechanisms in clonidine induced analgesia in rat tail-flick test 80
Modulation of Chronic Pain by Metabotropic Glutamate Receptors. 80
L-acetylcarnitine: A mechanistically distinctive and potentially rapid-acting antidepressant drug 79
Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain 78
Effects of Dynorphin A 1-13 on hyperalgesia induced by interleukin-1beta 75
Metabotropic glutamate receptor 2/3 expression is regulated by the NF-kB pathway in primary dorsal root ganglia neuron culture: A possible mechanism for L-acetylcanitine-induced mGlu2 upregulation 73
Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs 72
Pregabalin in the treatment of chronic pain: an overview 72
Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons. 71
Hyperalgesic activity of kisspeptin in persistent pain. 70
Up-regulation of mgluR2/3 in the spinal cord: a possible substrate for the protective action of L-acetyl-carnitine against the development of neuropatic pain 70
mGlu2 and mGlu3 receptors differently modulate inflammatory pain in mice 69
The SSRI, citalopram, improves bradykinesia in patients with Parkinson's disease treated with L-dopa 69
Synthesis of carboxyalkilthio-triazoles and bicyclic derivatives with antiinflammatory and analgesic activity 67
UP-REGULATION OF MGLUR2/3 IN THE SPINAL CORD: A POSSIBILE SUBSTRATE FOR THE PROTECTIVE ACTION OF L-ACETYLCARNITINE AGAINST THE DEVELOPMENT OF NEUROPATHIC PAIN.S. Chiechio, M. Storto, R. Ngomba, M. Vertecly, G. Scoto, F. Nicoletti 67
Epigenetic control of chronic pain mechanism 65
Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain 65
Gastro-resistant spray-dried CITRUS AURANTIUM extract microsystems: improvement of dissolution rate and pharmacological activity 63
Histone deacetylase inhibitors increase mGlu2 receptor expression in the mouse spinal cord: a new strategy for the treatment of persistent pain 63
EFFECTS OF DYNORPHIN A 1-13 ON HYPERALGESIA INDUCED BY INTERLEUCHIN-1 BETA IN THE RAT 62
Monomeric ß-amyloid activities rely on specific receptor engagement 60
Shared and distinct features of beta-amyloid peptides 59
mGlu2 and mGlu3 receptors differently modulate inflammatory pain in mice 59
GASTRO-RESISTANT SPRAY-DRIED CITRUS AURANTIUM EXTRACT MICROSYSTEMS: IMPROVEMENT OF DISSOLUTION RATE AND PHARMACOLOGICAL ACIVITY 56
The enhancement of morphine aninociception by a CCK-B receptor antagonist in the rat formalin test 51
The order of drug administration influences the interactive effects between ethanol and antidepressants on rat tail-flick test 46
Increased analgesic potency of morphine following repeated anaphylactoid reaction by compound 48/80 involves cyclooxygenase products of arachidonic acid 46
Totale 10.987
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Categoria #
all - tutte 34.066
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 34.066
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022699 80 89 4 22 103 7 100 34 60 25 24 151
2022/20231.371 97 64 13 126 115 193 4 427 254 25 35 18
2023/2024569 34 99 30 45 27 117 15 34 0 18 105 45
2024/20252.209 21 319 120 104 482 265 131 94 187 175 140 171
2025/20264.263 275 204 745 198 641 821 562 69 223 288 135 102
2026/202713 13 0 0 0 0 0 0 0 0 0 0 0
Totale 11.067