IRIS
CHIECHIO, SANTINA
 Distribuzione geografica
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Continente #
NA - Nord America 4.299
EU - Europa 1.649
AS - Asia 1.590
SA - Sud America 310
AF - Africa 214
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 2
Totale 8.069
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Nazione #
US - Stati Uniti d'America 4.154
SG - Singapore 657
CN - Cina 534
IT - Italia 511
IE - Irlanda 333
UA - Ucraina 307
BR - Brasile 287
HK - Hong Kong 213
CI - Costa d'Avorio 140
DE - Germania 138
CA - Canada 130
RU - Federazione Russa 86
SE - Svezia 60
GB - Regno Unito 46
SN - Senegal 45
KR - Corea 39
IN - India 34
FR - Francia 31
BE - Belgio 29
JP - Giappone 21
PL - Polonia 20
VN - Vietnam 20
FI - Finlandia 17
AT - Austria 14
ES - Italia 12
UZ - Uzbekistan 12
AR - Argentina 11
CH - Svizzera 11
NL - Olanda 11
IQ - Iraq 10
TR - Turchia 10
ZA - Sudafrica 10
BD - Bangladesh 9
CZ - Repubblica Ceca 7
IR - Iran 7
MX - Messico 7
PK - Pakistan 7
NG - Nigeria 6
VE - Venezuela 6
MA - Marocco 5
EU - Europa 4
ID - Indonesia 4
NP - Nepal 4
BG - Bulgaria 3
CO - Colombia 3
EG - Egitto 3
GR - Grecia 3
HU - Ungheria 3
TT - Trinidad e Tobago 3
AL - Albania 2
AZ - Azerbaigian 2
DO - Repubblica Dominicana 2
KE - Kenya 2
AE - Emirati Arabi Uniti 1
AU - Australia 1
BH - Bahrain 1
BW - Botswana 1
CL - Cile 1
EC - Ecuador 1
HN - Honduras 1
JM - Giamaica 1
JO - Giordania 1
LB - Libano 1
LI - Liechtenstein 1
LV - Lettonia 1
MG - Madagascar 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PA - Panama 1
PE - Perù 1
PS - Palestinian Territory 1
PT - Portogallo 1
SA - Arabia Saudita 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
TN - Tunisia 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 8.069
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Città #
Dallas 708
Houston 558
Santa Clara 538
Chandler 382
Singapore 363
Dublin 331
Jacksonville 289
Chicago 191
Catania 178
Boardman 156
Abidjan 140
Ashburn 121
Hefei 96
Nanjing 95
Cambridge 92
Lawrence 92
Andover 91
Toronto 86
Beijing 64
Grafing 59
San Mateo 54
Wilmington 50
Civitanova Marche 45
Dakar 45
Bremen 40
Seoul 39
Council Bluffs 35
Des Moines 35
Los Angeles 31
Brussels 28
Nanchang 27
Shenyang 27
São Paulo 27
The Dalles 26
Ottawa 24
Hebei 23
Jiaxing 23
Rome 22
Columbus 21
Changsha 18
Saint Petersburg 18
Naples 16
Tokyo 15
Munich 14
New York 13
Tianjin 12
Jinan 10
London 10
Norwalk 10
Pune 10
Warsaw 10
Augusta 9
Seattle 9
Belo Horizonte 8
Dong Ket 8
Leawood 8
Misterbianco 8
Montreal 8
Turku 8
Washington 8
Ann Arbor 7
Baghdad 7
Castelmola 7
Falls Church 7
Ho Chi Minh City 7
Messina 7
Moscow 7
Porto Alegre 7
Siracusa 7
Atlanta 6
Boston 6
Chennai 6
Dearborn 6
Guangzhou 6
Hong Kong 6
Paternò 6
Turin 6
Brasília 5
Frankfurt Am Main 5
Fukuoka 5
Fuzhou 5
Heidelberg 5
Helsinki 5
Johannesburg 5
Mexico City 5
Monmouth Junction 5
Phoenix 5
Rio de Janeiro 5
Salvador 5
Vienna 5
Abuja 4
Amsterdam 4
Ardabil 4
Bologna 4
Brooklyn 4
Charlotte 4
Civitavecchia 4
Curitiba 4
Fairfield 4
Fremont 4
Totale 5.698
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Nome #
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation 391
N-acetylcysteine causes analgesia by activating group II metabotropic glutamate receptors 299
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 265
Metabotropic glutamate receptors and the control of chronic pain. 162
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 125
Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond. 122
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 120
β-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: Correlation with the MAP kinase pathway 114
Role of DNA polymerase expression in beta-amyloyd-induced neuronal death 112
Increased heat pain tolerance but hyperalgesia to tonic inflammatory pain in the CRND8 mouse model of Alzheimer’s disease 110
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 107
Erratic expression of DNA polymerases by beta-amyloid causes neuronal death 106
LP2 e 2S-LP2: agonisti biased dual target MOR/DOR nel trattamento del dolore cronico 105
Intercellular communication and ion channels in neuropathic pain chronicization 104
Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization 102
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 102
Chronic treatment with fluoxetine induces sex-dependent analgesic effects and modulates HDAC2 and mGlu2 expression in female mice 98
Prediction of the response to citalopram and reboxetine in post-stroke depressed patients 97
Beta-Amyloid Monomer and Insulin/IGF-1 Signaling in Alzheimer's Disease 96
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 96
Central and peripheral control by endogenous opioid peptides of gastric protection in stressed-rats 96
Acetyl-L-carnitine in neuropathic pain: experimental data 96
Hyperalgesic activity of kisspeptin in mice 96
A new function for ß-amyloid monomers 95
L-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies 94
Effects of phenformin on the proliferation of human tumor cell lines 91
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 90
Effect of CCK-8 on analgesia induced by cold-restraint stress in the rat 90
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 90
Bone morphogenetic protein-7 delays podocyte injury due to high glucose 89
Development, Characterization, and In Vitro and In Vivo Evaluation of Benzocaine- and Lidocaine-Loaded Nanostructrured Lipid Carriers 88
MOR/DOR targeting: an useful strategy in pain management 87
Effects of dinorphin 1-13 on hyperalgesia induced by interleukin-1bera in the rat 86
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. 86
Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes 85
Activation of group-III metabotropic glutamate receptors inhibits the production of rantes in cultured astrocytes 84
Novel neuronal targets for the acetylcholinesterase inhibitor donepezil 83
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain 82
Gender specific effects of fluoxetine, duloxetine and amitriptyline in pain behavior and spinal BDNF expression in mice 81
Progress in the development of more effective and safer analgesics for pain management 80
A standardized extract prepared from red orange and lemon wastes blocks high-fat diet-induced hyperglycemia and hyperlipidemia in mice 80
Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles 79
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 78
Re-use of waste products of the Citrus industry for Nutraceutical formulations with enhancement of dissolution rate and oral bioavailability 78
Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect. 78
Evaluation of the prophylactic efficacy of amitriptyline and citalopram, alone or in combination, in patients with comorbidity of depression, migraine, and tension-type headache 76
Effect of donepezil on the proliferation and differentiation of SH-SY5Y neuroblastoma cells 76
Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity 75
Curcumin loaded NLC induces histone hypoacetylation in the CNS after intraperitoneal administration in mice. 74
Metabotropic receptors as target for drugs of potential use in the treatment of neuropathic pain 74
Inhibition of pain response in the formalin test by naloxone in normal- or cold-.restrained-rats 72
HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors 71
Synthesis of carboxyalkylthio-triazoles and bicyclic derivatives with antiinflammatory and analgesic activity 70
CURCUMIN LOADED NLC INDUCES HISTONE HYPOACETYLATION IN THE CNS AFTER INTRAPERITONEAL ADMINISTRATION IN MICE 70
H3-HISTAMINE RECEPTORS AND CLONIDINE ANALGESIA IN RATS. INFLAMM RES. 1997 MAR;46 SUPPL 1:S43-4 69
L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors 69
L-acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors 68
Preparation and analgesic activity of Eudragit RS100 microparticles containing diflunisal 67
Epigenetic control of chronic pain mechanism 67
An evaluation of efficacy and safety of reboxetine in elderly patients affected by "retarded" post-stroke depression. A random, placebo-controlled study 67
mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists 67
Modulation of Chronic Pain by Metabotropic Glutamate Receptors. 66
Estrogen stimulates beta amyloid peptide degradation through up-regulation of matrix mealloproteinases 2 and 9. 66
Lipid nanoparticle inclusion prevents capsaicin-induced TRPV1 defunctionalization. 65
Simultaneous activation of mu and delta opioid receptors reduces allodynia and astrocytic connexin 43 in an animal model of neuropathic pain 65
Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain 64
Biological activities of ß-amyloid monomers 63
Multitarget MOR/DOR antinociceptive ligands as useful profile in pain management: synthesis and pharmacological studies of 6,7-benzomorphan-based LP2 and its isomers 63
Histaminergic mechanisms in clonidine induced analgesia in rat tail-flick test 62
Gender specific effects of antidepressant drugs in pain behavior and spinal BDNF expression in mice 61
EVIDENCE OF A KEY-ROLE FOR HISTAMINE FROM MAST CELLS IN THE ANALGESIC EFFECT OF CLOMIPRAMINE IN RATS. INFLAMM RES. 1998 FEB;47(2):44-8 60
Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain 60
An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats 60
Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine 58
Pregabalin in the treatment of chronic pain: an overview 56
Exploring the Role of Hsp60 in Alzheimer's Disease and Type 2 Diabetes: Suggestion for Common Drug Targeting 56
Effects of Dynorphin A 1-13 on hyperalgesia induced by interleukin-1beta 55
L-acetylcarnitine: A mechanistically distinctive and potentially rapid-acting antidepressant drug 55
Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs 54
Targeting chronic pain with epigenetic drugs: Focus on mGlu2 receptors 54
Up-regulation of mgluR2/3 in the spinal cord: a possible substrate for the protective action of L-acetyl-carnitine against the development of neuropatic pain 53
MOR/DOR Dual-Target Approach: 2S-LP2 Effects in Inflammatory and Neuropathic Pain 53
Hyperalgesic activity of kisspeptin in persistent pain. 52
Metabotropic glutamate receptor 2/3 expression is regulated by the NF-kB pathway in primary dorsal root ganglia neuron culture: A possible mechanism for L-acetylcanitine-induced mGlu2 upregulation 50
The SSRI, citalopram, improves bradykinesia in patients with Parkinson's disease treated with L-dopa 50
mGlu2 and mGlu3 receptors differently modulate inflammatory pain in mice 49
Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons. 48
Synthesis of carboxyalkilthio-triazoles and bicyclic derivatives with antiinflammatory and analgesic activity 48
UP-REGULATION OF MGLUR2/3 IN THE SPINAL CORD: A POSSIBILE SUBSTRATE FOR THE PROTECTIVE ACTION OF L-ACETYLCARNITINE AGAINST THE DEVELOPMENT OF NEUROPATHIC PAIN.S. Chiechio, M. Storto, R. Ngomba, M. Vertecly, G. Scoto, F. Nicoletti 47
Gastro-resistant spray-dried CITRUS AURANTIUM extract microsystems: improvement of dissolution rate and pharmacological activity 46
Memantine and Amantadine KLVFF peptide conjugates: Synthesis, structure determination, amyloid-β interaction and effects on recognition memory in mice 45
EFFECTS OF DYNORPHIN A 1-13 ON HYPERALGESIA INDUCED BY INTERLEUCHIN-1 BETA IN THE RAT 45
Shared and distinct features of beta-amyloid peptides 45
Histone deacetylase inhibitors increase mGlu2 receptor expression in the mouse spinal cord: a new strategy for the treatment of persistent pain 44
Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain 42
GASTRO-RESISTANT SPRAY-DRIED CITRUS AURANTIUM EXTRACT MICROSYSTEMS: IMPROVEMENT OF DISSOLUTION RATE AND PHARMACOLOGICAL ACIVITY 41
mGlu2 and mGlu3 receptors differently modulate inflammatory pain in mice 40
Epigenetic control of chronic pain mechanism 40
Monomeric ß-amyloid activities rely on specific receptor engagement 38
The order of drug administration influences the interactive effects between ethanol and antidepressants on rat tail-flick test 29
Totale 8.175
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Categoria #
all - tutte 27.366
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.366
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021577 0 0 0 18 165 31 66 8 111 8 125 45
2021/2022724 83 92 6 23 105 7 103 37 63 25 27 153
2022/20231.395 99 64 13 127 120 198 4 432 260 25 35 18
2023/2024581 34 100 32 45 27 122 15 36 0 18 107 45
2024/20252.248 21 325 122 106 491 269 131 99 188 177 143 176
2025/20261.304 282 207 756 59 0 0 0 0 0 0 0 0
Totale 8.255