IRIS
CHIECHIO, SANTINA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 3.416
EU - Europa 1.601
AS - Asia 1.242
SA - Sud America 242
AF - Africa 151
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 2
Totale 6.658
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 3.289
SG - Singapore 572
IT - Italia 505
CN - Cina 371
IE - Irlanda 333
UA - Ucraina 305
BR - Brasile 226
HK - Hong Kong 207
DE - Germania 135
CA - Canada 117
CI - Costa d'Avorio 88
RU - Federazione Russa 83
SE - Svezia 56
SN - Senegal 45
GB - Regno Unito 32
BE - Belgio 29
FR - Francia 25
IN - India 25
PL - Polonia 17
FI - Finlandia 16
AT - Austria 14
JP - Giappone 13
CH - Svizzera 11
UZ - Uzbekistan 11
NL - Olanda 10
ES - Italia 9
VN - Vietnam 9
AR - Argentina 8
BD - Bangladesh 7
CZ - Repubblica Ceca 7
IR - Iran 7
ZA - Sudafrica 6
NG - Nigeria 5
VE - Venezuela 5
EU - Europa 4
PK - Pakistan 4
TR - Turchia 4
BG - Bulgaria 3
CO - Colombia 3
GR - Grecia 3
HU - Ungheria 3
IQ - Iraq 3
MA - Marocco 3
MX - Messico 3
NP - Nepal 3
AL - Albania 2
DO - Repubblica Dominicana 2
EG - Egitto 2
TT - Trinidad e Tobago 2
AE - Emirati Arabi Uniti 1
AU - Australia 1
AZ - Azerbaigian 1
BH - Bahrain 1
HN - Honduras 1
JM - Giamaica 1
JO - Giordania 1
KE - Kenya 1
LI - Liechtenstein 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PA - Panama 1
PS - Palestinian Territory 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
TN - Tunisia 1
Totale 6.658
Salva come PNG Salva come JPEG
Città #
Houston 558
Santa Clara 535
Chandler 382
Dublin 331
Singapore 305
Jacksonville 288
Chicago 185
Catania 176
Boardman 156
Nanjing 95
Ashburn 94
Cambridge 92
Lawrence 92
Andover 91
Abidjan 88
Toronto 84
Grafing 59
San Mateo 54
Wilmington 50
Civitanova Marche 45
Dakar 45
Bremen 40
Des Moines 35
Brussels 28
Council Bluffs 27
Nanchang 27
Shenyang 27
The Dalles 26
Ottawa 24
Hebei 23
Jiaxing 23
Rome 21
Beijing 20
São Paulo 20
Changsha 18
Saint Petersburg 18
Naples 16
Los Angeles 15
Munich 14
Tianjin 12
Jinan 10
Norwalk 10
Pune 10
Augusta 9
Dong Ket 8
Leawood 8
Misterbianco 8
Seattle 8
Turku 8
Ann Arbor 7
Castelmola 7
Falls Church 7
Hefei 7
Messina 7
Moscow 7
New York 7
Siracusa 7
Tokyo 7
Warsaw 7
Washington 7
Belo Horizonte 6
Dearborn 6
Guangzhou 6
Paternò 6
Turin 6
Frankfurt Am Main 5
Fukuoka 5
Fuzhou 5
Heidelberg 5
Helsinki 5
London 5
Monmouth Junction 5
Vienna 5
Abuja 4
Amsterdam 4
Ardabil 4
Bologna 4
Civitavecchia 4
Fairfield 4
Fremont 4
Haikou 4
Kunming 4
Liberty Lake 4
Marseille 4
Modica 4
Palermo 4
Phoenix 4
Porto Alegre 4
Pozzallo 4
Rio de Janeiro 4
Salerno 4
Salvador 4
Tappahannock 4
Zhengzhou 4
Baghdad 3
Bauru 3
Benevento 3
Brasília 3
Budapest 3
Cagliari 3
Totale 4.567
Salva come PNG Salva come JPEG
Nome #
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation 377
N-acetylcysteine causes analgesia by activating group II metabotropic glutamate receptors 271
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 211
Metabotropic glutamate receptors and the control of chronic pain. 155
Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond. 110
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 110
Role of DNA polymerase expression in beta-amyloyd-induced neuronal death 100
Prediction of the response to citalopram and reboxetine in post-stroke depressed patients 92
Intercellular communication and ion channels in neuropathic pain chronicization 90
Hyperalgesic activity of kisspeptin in mice 89
β-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: Correlation with the MAP kinase pathway 89
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 89
Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization 88
LP2 e 2S-LP2: agonisti biased dual target MOR/DOR nel trattamento del dolore cronico 86
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 86
Increased heat pain tolerance but hyperalgesia to tonic inflammatory pain in the CRND8 mouse model of Alzheimer’s disease 85
Beta-Amyloid Monomer and Insulin/IGF-1 Signaling in Alzheimer's Disease 85
L-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies 85
Acetyl-L-carnitine in neuropathic pain: experimental data 82
Chronic treatment with fluoxetine induces sex-dependent analgesic effects and modulates HDAC2 and mGlu2 expression in female mice 82
Effect of CCK-8 on analgesia induced by cold-restraint stress in the rat 79
Central and peripheral control by endogenous opioid peptides of gastric protection in stressed-rats 79
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 75
Effects of phenformin on the proliferation of human tumor cell lines 75
Development, Characterization, and In Vitro and In Vivo Evaluation of Benzocaine- and Lidocaine-Loaded Nanostructrured Lipid Carriers 75
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 73
Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect. 73
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain 72
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. 71
Activation of group-III metabotropic glutamate receptors inhibits the production of rantes in cultured astrocytes 71
Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes 71
Effects of dinorphin 1-13 on hyperalgesia induced by interleukin-1bera in the rat 70
Bone morphogenetic protein-7 delays podocyte injury due to high glucose 70
A new function for ß-amyloid monomers 70
Progress in the development of more effective and safer analgesics for pain management 70
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 69
Erratic expression of DNA polymerases by beta-amyloid causes neuronal death 69
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 69
MOR/DOR targeting: an useful strategy in pain management 69
Novel neuronal targets for the acetylcholinesterase inhibitor donepezil 68
A standardized extract prepared from red orange and lemon wastes blocks high-fat diet-induced hyperglycemia and hyperlipidemia in mice 68
Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles 67
Gender specific effects of fluoxetine, duloxetine and amitriptyline in pain behavior and spinal BDNF expression in mice 66
Effect of donepezil on the proliferation and differentiation of SH-SY5Y neuroblastoma cells 64
Re-use of waste products of the Citrus industry for Nutraceutical formulations with enhancement of dissolution rate and oral bioavailability 63
An evaluation of efficacy and safety of reboxetine in elderly patients affected by "retarded" post-stroke depression. A random, placebo-controlled study 63
Evaluation of the prophylactic efficacy of amitriptyline and citalopram, alone or in combination, in patients with comorbidity of depression, migraine, and tension-type headache 62
Curcumin loaded NLC induces histone hypoacetylation in the CNS after intraperitoneal administration in mice. 62
Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity 60
Inhibition of pain response in the formalin test by naloxone in normal- or cold-.restrained-rats 59
HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors 59
L-acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors 59
CURCUMIN LOADED NLC INDUCES HISTONE HYPOACETYLATION IN THE CNS AFTER INTRAPERITONEAL ADMINISTRATION IN MICE 59
Lipid nanoparticle inclusion prevents capsaicin-induced TRPV1 defunctionalization. 58
Synthesis of carboxyalkylthio-triazoles and bicyclic derivatives with antiinflammatory and analgesic activity 57
mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists 57
H3-HISTAMINE RECEPTORS AND CLONIDINE ANALGESIA IN RATS. INFLAMM RES. 1997 MAR;46 SUPPL 1:S43-4 56
L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors 56
Modulation of Chronic Pain by Metabotropic Glutamate Receptors. 56
Epigenetic control of chronic pain mechanism 56
Biological activities of ß-amyloid monomers 56
Metabotropic receptors as target for drugs of potential use in the treatment of neuropathic pain 56
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 55
Estrogen stimulates beta amyloid peptide degradation through up-regulation of matrix mealloproteinases 2 and 9. 55
Simultaneous activation of mu and delta opioid receptors reduces allodynia and astrocytic connexin 43 in an animal model of neuropathic pain 54
Preparation and analgesic activity of Eudragit RS100 microparticles containing diflunisal 53
Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain 53
An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats 52
Gender specific effects of antidepressant drugs in pain behavior and spinal BDNF expression in mice 51
Multitarget MOR/DOR antinociceptive ligands as useful profile in pain management: synthesis and pharmacological studies of 6,7-benzomorphan-based LP2 and its isomers 50
Histaminergic mechanisms in clonidine induced analgesia in rat tail-flick test 49
EVIDENCE OF A KEY-ROLE FOR HISTAMINE FROM MAST CELLS IN THE ANALGESIC EFFECT OF CLOMIPRAMINE IN RATS. INFLAMM RES. 1998 FEB;47(2):44-8 48
Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain 48
Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine 47
Up-regulation of mgluR2/3 in the spinal cord: a possible substrate for the protective action of L-acetyl-carnitine against the development of neuropatic pain 46
Metabotropic glutamate receptor 2/3 expression is regulated by the NF-kB pathway in primary dorsal root ganglia neuron culture: A possible mechanism for L-acetylcanitine-induced mGlu2 upregulation 46
mGlu2 and mGlu3 receptors differently modulate inflammatory pain in mice 46
Pregabalin in the treatment of chronic pain: an overview 46
L-acetylcarnitine: A mechanistically distinctive and potentially rapid-acting antidepressant drug 46
Targeting chronic pain with epigenetic drugs: Focus on mGlu2 receptors 45
Effects of Dynorphin A 1-13 on hyperalgesia induced by interleukin-1beta 44
Hyperalgesic activity of kisspeptin in persistent pain. 44
UP-REGULATION OF MGLUR2/3 IN THE SPINAL CORD: A POSSIBILE SUBSTRATE FOR THE PROTECTIVE ACTION OF L-ACETYLCARNITINE AGAINST THE DEVELOPMENT OF NEUROPATHIC PAIN.S. Chiechio, M. Storto, R. Ngomba, M. Vertecly, G. Scoto, F. Nicoletti 43
Exploring the Role of Hsp60 in Alzheimer's Disease and Type 2 Diabetes: Suggestion for Common Drug Targeting 43
Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs 42
MOR/DOR Dual-Target Approach: 2S-LP2 Effects in Inflammatory and Neuropathic Pain 42
The SSRI, citalopram, improves bradykinesia in patients with Parkinson's disease treated with L-dopa 41
Synthesis of carboxyalkilthio-triazoles and bicyclic derivatives with antiinflammatory and analgesic activity 41
Histone deacetylase inhibitors increase mGlu2 receptor expression in the mouse spinal cord: a new strategy for the treatment of persistent pain 39
Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain 39
EFFECTS OF DYNORPHIN A 1-13 ON HYPERALGESIA INDUCED BY INTERLEUCHIN-1 BETA IN THE RAT 38
Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons. 38
Gastro-resistant spray-dried CITRUS AURANTIUM extract microsystems: improvement of dissolution rate and pharmacological activity 36
Monomeric ß-amyloid activities rely on specific receptor engagement 35
Shared and distinct features of beta-amyloid peptides 34
mGlu2 and mGlu3 receptors differently modulate inflammatory pain in mice 31
Epigenetic control of chronic pain mechanism 30
GASTRO-RESISTANT SPRAY-DRIED CITRUS AURANTIUM EXTRACT MICROSYSTEMS: IMPROVEMENT OF DISSOLUTION RATE AND PHARMACOLOGICAL ACIVITY 29
Preparation and analgesic activity evaluation of NSAIDs-loaded Eudragit RS100„¥ microparticles 18
Memantine and Amantadine KLVFF peptide conjugates: Synthesis, structure determination, amyloid-β interaction and effects on recognition memory in mice 8
Totale 6.824
Salva come PNG Salva come JPEG
Categoria #
all - tutte 22.660
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 22.660
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202027 0 0 0 0 0 0 0 0 0 0 0 27
2020/2021705 10 49 69 18 165 31 66 8 111 8 125 45
2021/2022724 83 92 6 23 105 7 103 37 63 25 27 153
2022/20231.395 99 64 13 127 120 198 4 432 260 25 35 18
2023/2024581 34 100 32 45 27 122 15 36 0 18 107 45
2024/20252.141 21 325 122 106 491 269 131 99 188 177 143 69
Totale 6.844