IRIS
CHIECHIO, SANTINA
 Distribuzione geografica
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Continente #
NA - Nord America 2.367
EU - Europa 1.409
AS - Asia 577
AF - Africa 145
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 2
SA - Sud America 1
Totale 4.505
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Nazione #
US - Stati Uniti d'America 2.255
IE - Irlanda 347
IT - Italia 346
UA - Ucraina 309
CN - Cina 302
HK - Hong Kong 207
DE - Germania 126
CA - Canada 112
CI - Costa d'Avorio 93
RU - Federazione Russa 79
SE - Svezia 57
SN - Senegal 46
BE - Belgio 31
GB - Regno Unito 26
IN - India 25
FR - Francia 24
AT - Austria 13
CH - Svizzera 12
PL - Polonia 10
UZ - Uzbekistan 9
VN - Vietnam 9
SG - Singapore 8
IR - Iran 7
JP - Giappone 7
ES - Italia 6
NG - Nigeria 5
NL - Olanda 5
EU - Europa 4
BG - Bulgaria 3
CZ - Repubblica Ceca 3
GR - Grecia 3
HU - Ungheria 3
FI - Finlandia 2
AU - Australia 1
BR - Brasile 1
EG - Egitto 1
IL - Israele 1
LI - Liechtenstein 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
TR - Turchia 1
Totale 4.505
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Città #
Houston 558
Chandler 399
Dublin 345
Jacksonville 296
Catania 134
Nanjing 100
Cambridge 95
Lawrence 95
Andover 94
Abidjan 93
Ashburn 93
Toronto 85
Grafing 64
Boardman 58
San Mateo 55
Wilmington 50
Dakar 46
Bremen 42
Des Moines 39
Brussels 30
Shenyang 29
Nanchang 28
Ottawa 24
Hebei 23
Jiaxing 23
Changsha 19
Saint Petersburg 19
Tianjin 12
Rome 11
Jinan 10
Norwalk 10
Pune 10
Augusta 9
Beijing 8
Dong Ket 8
Leawood 8
Moscow 8
Ann Arbor 7
Falls Church 7
Misterbianco 7
Seattle 7
Siracusa 7
Washington 7
Dearborn 6
Messina 6
Monmouth Junction 6
Frankfurt Am Main 5
Fukuoka 5
Heidelberg 5
Turin 5
Abuja 4
Ardabil 4
Bologna 4
Civitavecchia 4
Fairfield 4
Fremont 4
Fuzhou 4
Guangzhou 4
Haikou 4
Hangzhou 4
Kunming 4
Liberty Lake 4
Los Angeles 4
Marseille 4
Tappahannock 4
Vienna 4
Zhengzhou 4
Benevento 3
Budapest 3
Groningen 3
London 3
Modica 3
Ningbo 3
Redwood City 3
Riposto 3
San Giovanni la Punta 3
Bangalore 2
Barcelona 2
Buffalo 2
Camerino 2
Cergy 2
Chioggia 2
Den Haag 2
Ghisalba 2
Helsinki 2
Lago 2
Latina 2
Lausanne 2
Lecce 2
Lentini 2
Leonforte 2
Milan 2
New York 2
North Shields 2
Palermo 2
Paris 2
Providence 2
Redmond 2
Reggio Calabria 2
Roccapiemonte 2
Totale 3.253
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Nome #
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation 353
N-acetylcysteine causes analgesia by activating group II metabotropic glutamate receptors 239
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 172
Metabotropic glutamate receptors and the control of chronic pain. 136
Role of DNA polymerase expression in beta-amyloyd-induced neuronal death 79
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 78
LP2 e 2S-LP2: agonisti biased dual target MOR/DOR nel trattamento del dolore cronico 72
L-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies 64
Intercellular communication and ion channels in neuropathic pain chronicization 61
Effect of CCK-8 on analgesia induced by cold-restraint stress in the rat 60
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 60
β-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: Correlation with the MAP kinase pathway 59
Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond. 57
Central and peripheral control by endogenous opioid peptides of gastric protection in stressed-rats 57
Beta-Amyloid Monomer and Insulin/IGF-1 Signaling in Alzheimer's Disease 56
Chronic treatment with fluoxetine induces sex-dependent analgesic effects and modulates HDAC2 and mGlu2 expression in female mice 55
Acetyl-L-carnitine in neuropathic pain: experimental data 54
MOR/DOR targeting: an useful strategy in pain management 53
Effects of dinorphin 1-13 on hyperalgesia induced by interleukin-1bera in the rat 51
Effects of phenformin on the proliferation of human tumor cell lines 51
Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect. 50
Bone morphogenetic protein-7 delays podocyte injury due to high glucose 49
Development, Characterization, and In Vitro and In Vivo Evaluation of Benzocaine- and Lidocaine-Loaded Nanostructrured Lipid Carriers 47
Novel neuronal targets for the acetylcholinesterase inhibitor donepezil 46
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 46
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 46
Inhibition of pain response in the formalin test by naloxone in normal- or cold-.restrained-rats 45
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. 44
Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity 44
Erratic expression of DNA polymerases by beta-amyloid causes neuronal death 44
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 44
Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles 44
MOR/DOR targeting: an useful strategy in pain management 44
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain 44
HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors 43
Hyperalgesic activity of kisspeptin in mice 43
Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes 43
Evaluation of the prophylactic efficacy of amitriptyline and citalopram, alone or in combination, in patients with comorbidity of depression, migraine, and tension-type headache 42
Activation of group-III metabotropic glutamate receptors inhibits the production of rantes in cultured astrocytes 42
Activation of group-III metabotropic glutamate receptors inhibits the production of rantes in cultured astrocytes 42
Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization 42
Lipid nanoparticle inclusion prevents capsaicin-induced TRPV1 defunctionalization. 41
Progress in the development of more effective and safer analgesics for pain management 41
H3-HISTAMINE RECEPTORS AND CLONIDINE ANALGESIA IN RATS. INFLAMM RES. 1997 MAR;46 SUPPL 1:S43-4 40
L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors 40
Synthesis of carboxyalkylthio-triazoles and bicyclic derivatives with antiinflammatory and analgesic activity 40
Re-use of waste products of the Citrus industry for Nutraceutical formulations with enhancement of dissolution rate and oral bioavailability 40
L-acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors 40
A new function for ß-amyloid monomers 40
Preparation and analgesic activity of Eudragit RS100 microparticles containing diflunisal 39
Effect of donepezil on the proliferation and differentiation of SH-SY5Y neuroblastoma cells 39
Gender specific effects of fluoxetine, duloxetine and amitriptyline in pain behavior and spinal BDNF expression in mice 39
An evaluation of efficacy and safety of reboxetine in elderly patients affected by "retarded" post-stroke depression. A random, placebo-controlled study 39
Prediction of the response to citalopram and reboxetine in post-stroke depressed patients 39
Increased heat pain tolerance but hyperalgesia to tonic inflammatory pain in the CRND8 mouse model of Alzheimer’s disease 38
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 38
CURCUMIN LOADED NLC INDUCES HISTONE HYPOACETYLATION IN THE CNS AFTER INTRAPERITONEAL ADMINISTRATION IN MICE 38
Epigenetic control of chronic pain mechanism 37
Curcumin loaded NLC induces histone hypoacetylation in the CNS after intraperitoneal administration in mice. 37
mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists 37
Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain 37
Biological activities of ß-amyloid monomers 36
Simultaneous activation of mu and delta opioid receptors reduces allodynia and astrocytic connexin 43 in an animal model of neuropathic pain 36
EVIDENCE OF A KEY-ROLE FOR HISTAMINE FROM MAST CELLS IN THE ANALGESIC EFFECT OF CLOMIPRAMINE IN RATS. INFLAMM RES. 1998 FEB;47(2):44-8 35
Preparation and analgesic activity of Eudragit RS100 (R) microparticles containing diflunisal 35
Modulation of Chronic Pain by Metabotropic Glutamate Receptors. 35
Estrogen stimulates beta amyloid peptide degradation through up-regulation of matrix mealloproteinases 2 and 9. 35
Histaminergic mechanisms in clonidine induced analgesia in rat tail-flick test 34
Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine 34
Metabotropic receptors as target for drugs of potential use in the treatment of neuropathic pain 34
Gender specific effects of antidepressant drugs in pain behavior and spinal BDNF expression in mice 33
mGlu2 and mGlu3 receptors differently modulate inflammatory pain in mice 33
Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain 32
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 31
Metabotropic glutamate receptor 2/3 expression is regulated by the NF-kB pathway in primary dorsal root ganglia neuron culture: A possible mechanism for L-acetylcanitine-induced mGlu2 upregulation 31
Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs 29
Pregabalin in the treatment of chronic pain: an overview 29
Multitarget MOR/DOR antinociceptive ligands as useful profile in pain management: synthesis and pharmacological studies of 6,7-benzomorphan-based LP2 and its isomers 29
A standardized extract prepared from red orange and lemon wastes blocks high-fat diet-induced hyperglycemia and hyperlipidemia in mice 29
Effects of Dynorphin A 1-13 on hyperalgesia induced by interleukin-1beta 28
Up-regulation of mgluR2/3 in the spinal cord: a possible substrate for the protective action of L-acetyl-carnitine against the development of neuropatic pain 27
EFFECTS OF DYNORPHIN A 1-13 ON HYPERALGESIA INDUCED BY INTERLEUCHIN-1 BETA IN THE RAT 27
An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats 27
UP-REGULATION OF MGLUR2/3 IN THE SPINAL CORD: A POSSIBILE SUBSTRATE FOR THE PROTECTIVE ACTION OF L-ACETYLCARNITINE AGAINST THE DEVELOPMENT OF NEUROPATHIC PAIN.S. Chiechio, M. Storto, R. Ngomba, M. Vertecly, G. Scoto, F. Nicoletti 27
The SSRI, citalopram, improves bradykinesia in patients with Parkinson's disease treated with L-dopa 26
Histone deacetylase inhibitors increase mGlu2 receptor expression in the mouse spinal cord: a new strategy for the treatment of persistent pain 25
L-acetylcarnitine: A mechanistically distinctive and potentially rapid-acting antidepressant drug 25
Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons. 25
Synthesis of carboxyalkilthio-triazoles and bicyclic derivatives with antiinflammatory and analgesic activity 25
Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain 24
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 23
Hyperalgesic activity of kisspeptin in persistent pain. 23
Gastro-resistant spray-dried CITRUS AURANTIUM extract microsystems: improvement of dissolution rate and pharmacological activity 23
Targeting chronic pain with epigenetic drugs: Focus on mGlu2 receptors 23
Shared and distinct features of beta-amyloid peptides 20
Monomeric ß-amyloid activities rely on specific receptor engagement 20
mGlu2 and mGlu3 receptors differently modulate inflammatory pain in mice 19
Epigenetic control of chronic pain mechanism 19
GASTRO-RESISTANT SPRAY-DRIED CITRUS AURANTIUM EXTRACT MICROSYSTEMS: IMPROVEMENT OF DISSOLUTION RATE AND PHARMACOLOGICAL ACIVITY 18
MOR/DOR Dual-Target Approach: 2S-LP2 Effects in Inflammatory and Neuropathic Pain 16
Totale 4.660
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Categoria #
all - tutte 13.131
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 13.131
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019157 0 0 0 0 0 0 0 0 0 0 22 135
2019/2020933 244 67 147 89 146 26 54 9 45 22 57 27
2020/2021733 10 50 72 18 169 31 68 8 117 10 135 45
2021/2022747 85 95 7 23 109 7 106 37 64 25 27 162
2022/20231.446 102 68 13 133 124 204 4 449 269 26 36 18
2023/2024442 34 106 33 45 28 126 15 36 0 18 1 0
Totale 4.687