IRIS
AMATA, EMANUELE
 Distribuzione geografica
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Continente #
NA - Nord America 3.972
EU - Europa 2.659
AS - Asia 2.109
AF - Africa 410
SA - Sud America 333
OC - Oceania 10
Totale 9.493
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Nazione #
US - Stati Uniti d'America 3.859
IT - Italia 1.269
SG - Singapore 863
CN - Cina 713
DE - Germania 390
IE - Irlanda 352
BR - Brasile 308
CI - Costa d'Avorio 292
HK - Hong Kong 221
FI - Finlandia 163
KR - Corea 126
RU - Federazione Russa 106
UA - Ucraina 98
CA - Canada 94
SN - Senegal 83
FR - Francia 48
GB - Regno Unito 48
ES - Italia 40
JP - Giappone 37
VN - Vietnam 37
NL - Olanda 29
IN - India 28
CZ - Repubblica Ceca 25
PL - Polonia 19
BD - Bangladesh 18
SE - Svezia 15
AT - Austria 14
BE - Belgio 12
UZ - Uzbekistan 12
MX - Messico 11
TR - Turchia 10
ZA - Sudafrica 10
CH - Svizzera 9
ID - Indonesia 9
GR - Grecia 8
AR - Argentina 7
AU - Australia 7
EC - Ecuador 7
IQ - Iraq 6
AE - Emirati Arabi Uniti 5
DZ - Algeria 5
CO - Colombia 4
IL - Israele 4
KE - Kenya 4
NG - Nigeria 4
CL - Cile 3
DO - Repubblica Dominicana 3
HU - Ungheria 3
KZ - Kazakistan 3
MA - Marocco 3
PE - Perù 3
PK - Pakistan 3
TN - Tunisia 3
BG - Bulgaria 2
CM - Camerun 2
EG - Egitto 2
ET - Etiopia 2
IR - Iran 2
JO - Giordania 2
LB - Libano 2
LT - Lituania 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
SA - Arabia Saudita 2
TH - Thailandia 2
TT - Trinidad e Tobago 2
AL - Albania 1
AZ - Azerbaigian 1
BB - Barbados 1
CR - Costa Rica 1
JM - Giamaica 1
LU - Lussemburgo 1
ME - Montenegro 1
MK - Macedonia 1
NC - Nuova Caledonia 1
NP - Nepal 1
OM - Oman 1
PS - Palestinian Territory 1
RO - Romania 1
VE - Venezuela 1
Totale 9.493
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Città #
Santa Clara 646
Chandler 617
Singapore 519
Dallas 420
Catania 354
Dublin 350
Chicago 326
Munich 299
Abidjan 292
Hefei 218
Ashburn 214
Boardman 144
Civitanova Marche 130
Seoul 125
Helsinki 120
Beijing 105
Jacksonville 104
Nanjing 96
Andover 89
Cambridge 88
Lawrence 88
Dakar 83
Houston 63
Toronto 60
Naples 51
Bremen 48
Des Moines 47
Rome 44
Los Angeles 42
Columbus 36
Tokyo 36
The Dalles 35
Council Bluffs 34
Saint Petersburg 27
Wilmington 27
Milan 26
Nanchang 24
São Paulo 23
Hebei 22
Messina 19
Dong Ket 18
Jiaxing 18
Palermo 18
Rio de Janeiro 18
Sala Baganza 18
Brno 17
Jyväskylä 17
Shenyang 17
Ottawa 16
Changsha 15
Centro 13
Grafing 13
Madrid 13
Amsterdam 12
Boydton 12
Brooklyn 12
Florence 12
Hong Kong 12
Leawood 12
New York 12
San Giovanni la Punta 12
Belo Horizonte 11
Brussels 11
Cagliari 11
Moscow 11
Tianjin 11
Washington 11
Bari 10
Guangzhou 10
Pozzallo 10
Seattle 10
Turku 10
Jakarta 9
Lappeenranta 9
San Francisco 9
Warsaw 9
Augusta 8
Hanoi 8
London 8
Montreal 8
Phoenix 8
Redmond 8
Santiago de Compostela 8
Bologna 7
Curitiba 7
East Stroudsburg 7
Gravina di Catania 7
Jinan 7
Ningbo 7
Norwalk 7
Rimini 7
Terrassa 7
Vienna 7
Den Haag 6
Ho Chi Minh City 6
Kunming 6
Marseille 6
Mascalucia 6
Osio Sotto 6
Paris 6
Totale 6.718
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Nome #
C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation 440
Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders 294
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors 223
Composti inorganici [Cap. 6] 207
Involvement of sigma 2 receptor on motor disorder 172
Antioxidant properties and pharmacokinetic studies of new selective σ1 bifunctional ligands 139
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands 136
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer 132
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti 124
[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor 120
DNA intercalators based on (1,10-phenanthrolin-2-yl)isoxazolidin-5-yl core with better growth inhibition and selectivity than cisplatin upon head and neck squamous cells carcinoma 118
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 113
Combination of heme oxygenase-1 inhibition and sigma receptor modulation for anticancer activity 110
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 109
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 105
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 105
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 104
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 104
Design of Small Molecules for Oncological and Neurodegenerative Diseases 101
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 101
Caspase-3 activation in human melanoma A375 cell line by a novel selective sigma-2 agonist 100
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma 99
Antioxidant activity of (+)-Pentazocine on activated microglia 98
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells 98
A pseudouridine isoxazolidinyl nucleoside analogue structural analysis: A morphological approach 97
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties 95
Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity 94
Synthesis of “no-light activated” Ciprofloxacin and Norfloxacin derivatives as potential biofilm dispersant agents 94
Sigma-2 receptor ligands QSAR model dataset 93
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation 93
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review 90
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines 90
La modellistica molecolare applicata ai recettori Sigma-1 e Sigma-2: un excursus 90
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors 89
Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands 88
A structure-and ligand-based virtual screening of a database of “small” marine natural products for the identification of “blue” sigma-2 receptor ligands 87
Fourfold filtered statistical/computational approach for the identification of imidazole compounds as HO-1 inhibitors from natural products 87
Tuning Properties for Blood-Brain Barrier Permeation: A Statistics-Based Analysis 87
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation 87
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands 85
S2RSLDB: A comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands 85
Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase 85
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands 84
Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma 83
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 82
Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors 81
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors 80
CNS permeability parameters determination through a statistical analysis driven approach 80
Tumor Targeting Sigma Receptor Ligands: Development of New Molecular Hybrids as Anticancer Therapeutics 79
Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 79
New selective Sigma-1/HDACi prodrugs for neurodegenerative disorders 79
Synthesis of Novel Benzylpiperazine Derivatives as Ligands for the σ1 Receptor 78
Antitrypanosomal lead discovery: Identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth 78
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management 76
In vitro and in vivo pharmacological evaluation of LP1, a benzomorphan-based compound 75
Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands 74
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 72
Novel Sigma Receptors Ligands-Nitric Oxide Photodonor: Molecular Hybrids for Double-Targeted Antiproliferative Effect 72
Development of NO-releasing sigma receptor hybrids as anticancer agents 72
Heme Oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia 71
Development of novel H2S-donor sigma receptor hybrids for the management of pain. 71
Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects 70
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity 69
Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries 69
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 68
Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D-QSAR Coupled to Scaffold-Hopping Analysis 68
Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation 68
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands 66
In-vitro evaluation of a new benzomorphan-based ligand 66
Synthesis and structure-activity relationships of (–)-cis-N-normetazocine-based LP1 derivatives 66
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors 65
Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents 64
Design and synthesis of new benzomorphan LP1 analogues, an opioid ligand with low development of tolerance 63
Haloperidol Metabolite II Valproate Ester: Antiangiogenic Activity in Human Microvascular Retinal Endothelial Cells 63
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors 62
Designing drugs optimized for both blood-brain barrier permeation and intra-cerebral partition 61
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands 61
Pain management: new long-acting opioid ligands 61
Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation 60
Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches 60
Evaluation of N-substitution in 6,7-benzomorphan compounds 60
Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1) 59
Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents 59
Synthesis and evaluation of haloperidol metabolite II prodrugs as anticancer agents 56
Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation 55
NLC as promising platform to deliver new prodrugs in the treatment of ophthalmic cancer 54
Repurposing of human kinase inhibitors in neglected protozoan diseases 54
Interaction of new sigma ligands with biomembrane models evaluated by differential scanning calorimetry and Langmuir-Blodgett studies 54
Nanostructured lipid carrier for the ophthalmic delivery of haloperidol metabolite II valproate ester (±)-MRJF22: A potential strategy in the treatment of uveal melanoma 53
Correction to Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 53
Development of new benzomorphan LP1 analogues 53
Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors 52
Discovery of 3-(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligands 52
Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign 51
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity 50
Heme Oxygenase-1 Inhibition: A Novel Strategy for the Design of Azole-Based Antitumour Agents 50
Targeting Heme Oxygenase-1 to Overcome Imatinib Resistance in Chronic Myeloid Leukemia 50
In vitro and in silico analysis of imatinib analogues as anti- Trypanosoma cruzi drug candidates 48
DESIGN, SYNTHESIS, MOLECULAR MODELING AND PHARMACOLOGICAL EVALUATION OF NOVEL DIAZABICYCLO[4.3.0]NONANE AND 2,7-DIAZASPIRO[3.5]NONANE AS SIGMA RECEPTORS LIGANDS 48
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics for Pain Treatment 46
Totale 8.821
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Categoria #
all - tutte 33.739
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.739
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021343 0 0 35 44 121 8 34 2 20 5 44 30
2021/2022718 61 100 31 17 115 5 105 31 42 20 10 181
2022/20231.918 138 124 30 241 116 248 10 501 348 34 91 37
2023/20241.101 56 150 57 60 75 310 66 44 6 21 177 79
2024/20253.577 120 493 145 264 586 424 333 179 322 240 227 244
2025/20261.285 452 425 408 0 0 0 0 0 0 0 0 0
Totale 9.935