IRIS
AMATA, EMANUELE
 Distribuzione geografica
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Continente #
NA - Nord America 5.331
AS - Asia 2.782
EU - Europa 2.775
AF - Africa 517
SA - Sud America 439
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 1
Totale 11.856
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Nazione #
US - Stati Uniti d'America 5.188
IT - Italia 1.302
SG - Singapore 1.209
CN - Cina 876
DE - Germania 390
BR - Brasile 386
CI - Costa d'Avorio 373
IE - Irlanda 352
HK - Hong Kong 232
FI - Finlandia 163
KR - Corea 134
VN - Vietnam 124
CA - Canada 110
RU - Federazione Russa 109
UA - Ucraina 99
SN - Senegal 83
GB - Regno Unito 72
FR - Francia 51
ES - Italia 50
JP - Giappone 49
IN - India 41
NL - Olanda 38
PL - Polonia 31
SE - Svezia 27
CZ - Repubblica Ceca 25
AR - Argentina 23
ID - Indonesia 23
BD - Bangladesh 22
MX - Messico 22
ZA - Sudafrica 17
AT - Austria 14
TR - Turchia 14
BE - Belgio 12
BJ - Benin 12
UZ - Uzbekistan 12
CH - Svizzera 11
EC - Ecuador 10
IQ - Iraq 9
GR - Grecia 8
AE - Emirati Arabi Uniti 7
AU - Australia 7
LT - Lituania 7
MA - Marocco 7
CO - Colombia 6
CL - Cile 5
DZ - Algeria 5
IL - Israele 5
IR - Iran 5
PE - Perù 5
EG - Egitto 4
KE - Kenya 4
NG - Nigeria 4
DO - Repubblica Dominicana 3
HU - Ungheria 3
KZ - Kazakistan 3
NZ - Nuova Zelanda 3
PK - Pakistan 3
SA - Arabia Saudita 3
TN - Tunisia 3
BG - Bulgaria 2
CM - Camerun 2
ET - Etiopia 2
HN - Honduras 2
JO - Giordania 2
LB - Libano 2
NO - Norvegia 2
PY - Paraguay 2
RS - Serbia 2
TH - Thailandia 2
TT - Trinidad e Tobago 2
VE - Venezuela 2
AL - Albania 1
AO - Angola 1
AZ - Azerbaigian 1
BB - Barbados 1
CR - Costa Rica 1
JM - Giamaica 1
LU - Lussemburgo 1
ME - Montenegro 1
MK - Macedonia 1
MY - Malesia 1
NC - Nuova Caledonia 1
NP - Nepal 1
OM - Oman 1
PS - Palestinian Territory 1
RO - Romania 1
SV - El Salvador 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 11.856
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Città #
Dallas 1.345
Santa Clara 655
Chandler 617
Singapore 611
Catania 377
Abidjan 373
Dublin 350
Chicago 328
Ashburn 305
Munich 299
Hefei 234
Beijing 151
Boardman 144
Seoul 133
Civitanova Marche 130
Helsinki 120
Jacksonville 104
Los Angeles 98
Nanjing 96
Andover 89
Cambridge 88
Lawrence 88
Dakar 83
Houston 73
Toronto 61
Naples 51
Bremen 48
Tokyo 48
Des Moines 47
New York 46
Rome 44
Ho Chi Minh City 42
Columbus 36
São Paulo 35
The Dalles 35
Council Bluffs 34
Buffalo 31
Milan 28
Saint Petersburg 27
Wilmington 27
Hanoi 25
Brooklyn 24
Nanchang 24
Hong Kong 23
Hebei 22
Montreal 22
Warsaw 20
Amsterdam 19
Denver 19
Messina 19
Palermo 19
Dong Ket 18
Jiaxing 18
Rio de Janeiro 18
Sala Baganza 18
Brno 17
Jakarta 17
Jyväskylä 17
Shenyang 17
Ottawa 16
Changsha 15
Atlanta 14
Stockholm 14
Belo Horizonte 13
Centro 13
Grafing 13
Madrid 13
Poplar 13
Boydton 12
Cotonou 12
Florence 12
Leawood 12
Moscow 12
Phoenix 12
San Giovanni la Punta 12
Seattle 12
Brussels 11
Cagliari 11
London 11
Tianjin 11
Washington 11
Bari 10
Curitiba 10
Guangzhou 10
Pozzallo 10
San Francisco 10
Turku 10
Chennai 9
Johannesburg 9
Lappeenranta 9
Augusta 8
Paris 8
Redmond 8
Santiago de Compostela 8
Bologna 7
East Stroudsburg 7
Gravina di Catania 7
Jinan 7
Ningbo 7
Norwalk 7
Totale 8.343
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Nome #
C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation 465
Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders 400
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors 252
Composti inorganici [Cap. 6] 232
Involvement of sigma 2 receptor on motor disorder 188
Antioxidant properties and pharmacokinetic studies of new selective σ1 bifunctional ligands 170
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands 158
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer 155
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 154
Caspase-3 activation in human melanoma A375 cell line by a novel selective sigma-2 agonist 142
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 142
[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor 142
Combination of heme oxygenase-1 inhibition and sigma receptor modulation for anticancer activity 141
DNA intercalators based on (1,10-phenanthrolin-2-yl)isoxazolidin-5-yl core with better growth inhibition and selectivity than cisplatin upon head and neck squamous cells carcinoma 139
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 138
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti 134
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 130
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells 129
A pseudouridine isoxazolidinyl nucleoside analogue structural analysis: A morphological approach 128
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 128
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties 122
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma 122
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 120
Design of Small Molecules for Oncological and Neurodegenerative Diseases 118
A structure-and ligand-based virtual screening of a database of “small” marine natural products for the identification of “blue” sigma-2 receptor ligands 118
Antioxidant activity of (+)-Pentazocine on activated microglia 117
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review 116
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors 116
Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma 115
Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity 113
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands 110
Synthesis of “no-light activated” Ciprofloxacin and Norfloxacin derivatives as potential biofilm dispersant agents 109
Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors 108
Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands 108
Sigma-2 receptor ligands QSAR model dataset 108
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation 107
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 106
Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation 104
La modellistica molecolare applicata ai recettori Sigma-1 e Sigma-2: un excursus 103
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines 102
Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 101
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management 100
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors 100
Fourfold filtered statistical/computational approach for the identification of imidazole compounds as HO-1 inhibitors from natural products 98
Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase 96
Tumor Targeting Sigma Receptor Ligands: Development of New Molecular Hybrids as Anticancer Therapeutics 95
Antitrypanosomal lead discovery: Identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth 95
Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands 95
Tuning Properties for Blood-Brain Barrier Permeation: A Statistics-Based Analysis 95
CNS permeability parameters determination through a statistical analysis driven approach 94
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 93
S2RSLDB: A comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands 92
Development of NO-releasing sigma receptor hybrids as anticancer agents 92
New selective Sigma-1/HDACi prodrugs for neurodegenerative disorders 91
Development of novel H2S-donor sigma receptor hybrids for the management of pain. 91
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity 88
Synthesis of Novel Benzylpiperazine Derivatives as Ligands for the σ1 Receptor 88
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands 87
Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches 87
Correction to Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents 87
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 85
Novel Sigma Receptors Ligands-Nitric Oxide Photodonor: Molecular Hybrids for Double-Targeted Antiproliferative Effect 85
Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands 85
Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation 85
In vitro and in vivo pharmacological evaluation of LP1, a benzomorphan-based compound 83
Haloperidol Metabolite II Valproate Ester: Antiangiogenic Activity in Human Microvascular Retinal Endothelial Cells 83
Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents 82
Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D-QSAR Coupled to Scaffold-Hopping Analysis 82
Designing drugs optimized for both blood-brain barrier permeation and intra-cerebral partition 81
Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects 81
Heme Oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia 81
In-vitro evaluation of a new benzomorphan-based ligand 81
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 79
Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation 78
Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries 77
Discovery of 3-(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligands 77
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands 76
Evaluation of N-substitution in 6,7-benzomorphan compounds 76
Pain management: new long-acting opioid ligands 76
Synthesis and structure-activity relationships of (–)-cis-N-normetazocine-based LP1 derivatives 75
Interaction of new sigma ligands with biomembrane models evaluated by differential scanning calorimetry and Langmuir-Blodgett studies 75
NLC as promising platform to deliver new prodrugs in the treatment of ophthalmic cancer 74
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands 74
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors 73
Novel sigma 1-antagonists with cis-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect 72
Nanostructured lipid carrier for the ophthalmic delivery of haloperidol metabolite II valproate ester (±)-MRJF22: A potential strategy in the treatment of uveal melanoma 72
Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents 71
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity 70
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics for Pain Treatment 69
Design and synthesis of new benzomorphan LP1 analogues, an opioid ligand with low development of tolerance 69
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors 68
DESIGN, SYNTHESIS, MOLECULAR MODELING AND PHARMACOLOGICAL EVALUATION OF NOVEL DIAZABICYCLO[4.3.0]NONANE AND 2,7-DIAZASPIRO[3.5]NONANE AS SIGMA RECEPTORS LIGANDS 67
Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1) 67
Identification of “Preferred” Human Kinase Inhibitors for Human African Trypanosomiasis Through a Statistical Analysis-Driven Approach 64
Repurposing of human kinase inhibitors in neglected protozoan diseases 64
Development of new benzomorphan LP1 analogues 64
Investigation of Tau-Dependent Epigenetic Reprogramming in Alzheimer’s Disease 63
Enhancing HDAC Inhibitor Screening: Addressing Zinc Parameterization and Ligand Protonation in Docking Studies 63
NOVEL N-NORMETAZOCINE DERIVATIVES WITH SIGMA-1 RECEPTOR ANTAGONIST PROFILE AS POTENTIAL ANALGESICS FOR INFLAMMATORY PAIN MANAGEMENT 62
Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors 62
Totale 10.745
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Categoria #
all - tutte 38.581
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 38.581
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021264 0 0 0 0 121 8 34 2 20 5 44 30
2021/2022718 61 100 31 17 115 5 105 31 42 20 10 181
2022/20231.918 138 124 30 241 116 248 10 501 348 34 91 37
2023/20241.101 56 150 57 60 75 310 66 44 6 21 177 79
2024/20253.577 120 493 145 264 586 424 333 179 322 240 227 244
2025/20263.648 452 425 1.528 503 740 0 0 0 0 0 0 0
Totale 12.298